1. Screening Libraries
  2. Serine/Threonine Kinase Inhibitor Library

Serine/Threonine Kinase Inhibitor Library

Cat. No.: HY-L164
Library Contents: XLSX PDF SDF

Protein serine/threonine kinases (PSKs) are protein kinases that use ATP as a high-energy donor molecule to transfer phosphate groups to serine/threonine residues of target protein. As an important signal transduction regulator, serine/threonine kinases can affect the function of target proteins by disrupting enzyme activity or binding of target proteins to other proteins. Serine/threonine kinases are involved in the regulation of immune response, cell proliferation, differentiation, apoptosis and other physiological processes. Serine/threonine kinase inhibitors are an important class of compounds that have been widely studied in cancer, chronic inflammation, autoimmune diseases, aging and other diseases.

MCE designs a unique collection of 1267 serine/threonine kinase inhibitors, mainly targeting the receptor PKA, Akt, PKC, MAPK/ERK, etc, which is an effective tool for development and research of anti-cancer, anti-chronic inflammatory diseases, anti-autoimmune diseases and anti-aging compounds.

MCE Serine/Threonine Kinase Inhibitor Library can be supplied as pre-dissolved Solutions or Solid. For pre-dissolved solutions in this library, there are 1232 compounds supplied in 10 mM solution, 33 compounds supplied in 2 mM solution and 2 compounds supplied in 3 mg/mL solution.

For pre-dissolved solutions, 10 mM for compounds with the solubility not lower than 10 mM, 2 mM for compounds with solubility between 2 mM and 10 mM, and 3 mg/mL for compounds with unconfirmed molecular weight and solubility not lower than 3 mg/mL.

  • 96-well Plate with Peelable Foil Seal
  • 384-well Microplate with Peelable Foil Seal
  • 96-well Storage Tubes with Rack
  • 96-well Storage Tubes with Rack
Size (Pre-dissolved Solution or Solid) Price Stock
30 μL/well Solution

10 mM , 2 mM and 3 mg/mL
Pre-dissolved Solution

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50 μL/well Solution

10 mM , 2 mM and 3 mg/mL
Pre-dissolved Solution

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100 μL/well Solution

10 mM , 2 mM and 3 mg/mL
Pre-dissolved Solution

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2 × 100 μL/well Solution

10 mM , 2 mM and 3 mg/mL
Pre-dissolved Solution

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Description
& Advantages

•    A unique collection of 1267 serine/threonine kinase inhibitors for high throughput screening (HTS) and high content screening (HCS).

•   The library contains compounds targeting the receptor PKA, Akt, PKC, MAPK/ERK, etc.

•   A useful tool for the discovery of anti-cancer, anti-chronic inflammatory diseases, anti-autoimmune diseases and anti-aging compounds.

•   Bioactivity and safety confirmed by preclinical research and clinical trials. Some have been approved by FDA.

•   Structurally diverse, bioactive, and cell permeable.

•   More detailed compound information with structure, IC50, and other chemical & biological data.

•   High purity and quality validated by NMR and LC/MS.

•   All compounds are in stock and continuously updated.

Product Details
Formulation:
A collection of 1267 bioactive serine/threonine kinase inhibitors supplied as pre-dissolved Solutions or Solid.
Solution: 1232 compounds supplied in 10 mM solution, 33 compounds supplied in 2 mM solution, 2 compounds supplied in 3 mg/mL solution.
Layout:
96-well storage tube or 96-well plate: 1st and 12th column are left empty.
384-well plate: the first two columns and the last two columns are left empty.
Compounds with different concentrations or dissolved in different solvents will be put on separate plates. This way of layout may increase the number of plates because there could be three solvents and three concentrations.
If you have other requirements, please let us know.
Container:
96- or 384-well Plate with Peelable Foil Seal; 96-well Format Sample Storage Tube With Screw Cap and Optional 2D Barcode
Storage:
In solvent: -80°C 2 years, -20°C 1 year; Powder: -20°C 3 years, 4°C 2 years
Shipping:
Blue ice or dry ice
Documentation

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    Product Name:
    Serine/Threonine Kinase Inhibitor Library
    Cat. No.:
    HY-L164
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    • 96-well Plate with Peelable Foil Seal
    • 384-well Microplate with Peelable Foil Seal
    • 96-well Storage Tubes with Rack
    • 96-well Storage Tubes with Rack