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CNS MPO Lead-like Library

Cat. No.: HY-L920

With the aging population and increasing competitive pressures, neurodegenerative diseases of the central nervous system (CNS) have become a serious medical challenge in modern society, including Parkinson's disease, Alzheimer's disease, brain tumors, and multiple sclerosis. The CNS MPO (Multi-Parameter Optimization) score is a widely recognized algorithm in medicinal chemistry. Developed by Pfizer, this method is based on an analysis of approved CNS drugs and their interior CNS drug candidates, establishing the CNS MPO rules. It incorporates six key physicochemical properties (ClogP, ClogD, MW, TPSA, HBD, and pKa) to prospectively optimize CNS drug attributes—such as high blood-brain barrier (BBB) permeability, low P-gp efflux liability, low metabolic clearance, and high safety—thereby improving the clinical success rate of CNS drug candidates. The CNS MPO compound library is a collection of compounds with CNS MPO scores greater than 5, specifically designed for CNS drug discovery.

  • 96-well Plate with Peelable Foil Seal
  • 384-well Microplate with Peelable Foil Seal
  • 96-well Storage Tubes with Rack
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Description & Advantages

•    A unique collection of 24,816 compounds with high MPO score can be used for high throughput screening (HTS) and high content screening (HCS).

•    A useful tool to conduct CNS drug discovery, such as brain tumors, mental disorders, and neurodegenerative diseases.

•    Acidic compounds have been removed due to their low permeability across the BBB.

•    All compounds are available off the shelf.

•    LCMS or NMR validation ensures high purity and quality.

Product Details

Formulation:

24,816 compounds with high MPO score, providing a promising starting point for CNS drug discovery.
Solution: 24,814 compounds supplied in 10 mM solution.

Container:

96- or 384-well Plate with Peelable Foil Seal; 96-well Format Sample Storage Tube With Screw Cap and Optional 2D Barcode.

Storage:

-80°C

Shipping:

Blue ice or dry ice

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    Product Name:
    CNS MPO Lead-like Library
    Cat. No.:
    HY-L920
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    • 96-well Plate with Peelable Foil Seal
    • 384-well Microplate with Peelable Foil Seal
    • 96-well Storage Tubes with Rack
    • 96-well Plate with Peelable Foil Seal
    • 384-well Microplate with Peelable Foil Seal
    • 96-well Storage Tubes with Rack

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