1. Signaling Pathways
  2. Metabolic Enzyme/Protease
  3. 15-PGDH


15-Hydroxyprostaglandin dehydrogenase

15-PGDH (15-Hydroxyprostaglandin dehydrogenase) is a tumor suppressor in breast, colon, liver, lung, and pancreas since decreased expression of this enzyme is associated with increased tumorigenesis. 15-PGDH metabolizes intracellular PGE2 so that this ligand is unable to bind EP receptors, which results in suppression of PGE2 signaling.

The tumor suppressor 15-PGDH is the key enzyme in prostaglandin E2 catabolism and is down-regulated in colorectal cancer (CRC) tissue. Canonical Wnt signaling is frequently elevated in colon cancers and has been shown to down-regulate 15-PGDH expression.

Inhibition of 15-PGDH, a prostaglandin-degrading enzyme, potentiates tissue regeneration in multiple organs in mice. 15-PGDH acts in vivo as a negative regulator of prostaglandin levels and activity, provides a candidate target.

15-PGDH Related Products (3):

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-16968
    Inhibitor 99.74%
    SW033291 is a potent and high-affinity inhibitor of 15-PGDH with a Ki of 0.1 nM. SW033291 increases prostaglandin PGE2 levels in bone marrow and other tissues. SW033291 also promotes tissue regeneration.
  • HY-151807
    Inhibitor 99.70%
    15-PGDH-IN-1 is a potent and orally active 15-PGDH inhibitior. 15-PGDH-IN-1 has inhibition activity against recombinant human 15-PGDH with an IC50 value of 3 nM. 15-PGDH-IN-1 can be used for the research of tissue repair and regeneration.
  • HY-123548
    Inhibitor 99.89%
    ML148 is a potent and selective 15-PGDH inhibitor with an IC50 of 56 nM. ML148 has the potential for the research of prostaglandin-signaling pathways.