1. Metabolic Enzyme/Protease
  2. 15-PGDH
  3. SW033291

SW033291 

Cat. No.: HY-16968 Purity: 99.62%
Handling Instructions

SW033291 is a potent and high-affinity inhibitor of 15-PGDH with a Ki of 0.1 nM. SW033291 increases prostaglandin PGE2 levels in bone marrow and other tissues. SW033291 also promotes tissue regeneration.

For research use only. We do not sell to patients.

SW033291 Chemical Structure

SW033291 Chemical Structure

CAS No. : 459147-39-8

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Free Sample (0.5-1 mg)   Apply Now  
10 mM * 1 mL in DMSO USD 110 In-stock
Estimated Time of Arrival: December 31
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10 mg USD 150 In-stock
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50 mg USD 450 In-stock
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100 mg USD 650 In-stock
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Based on 1 publication(s) in Google Scholar

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Description

SW033291 is a potent and high-affinity inhibitor of 15-PGDH with a Ki of 0.1 nM. SW033291 increases prostaglandin PGE2 levels in bone marrow and other tissues. SW033291 also promotes tissue regeneration[1].

IC50 & Target

Ki: 0.1 nM (15-PGDH)[1]

In Vitro

Treating cells with SW033291 decreases cellular 15-PGDH enzyme activity by 85%. SW033291 inhibition of 15-PGDH was non-competitive versus PGE2 over concentrations up to 40 μM PGE2. Treatment of A549 cells with SW033291 increases PGE2 levels by 3.5-fold at 500 nM, with an EC50 50 at approximately 75 nM[1].

In Vivo

SW033291 (10 mg/kg; intraperitoneal injection; twice daily; for 3 days; C57BL/6J mice) treatment for three consecutive days shows significant benefits, including a doubling of peripheral neutrophil counts, a 65% increase in marrow SKL cells, and a 71% increase in marrow SLAM cells[1].

Animal Model: C57BL/6J mice[1]
Dosage: 10 mg/kg
Administration: Intraperitoneal injection; twice daily; for 3 days ( for 5 doses)
Result: Showed significant benefits, including a doubling of peripheral neutrophil counts, a 65% increase in marrow SKL cells, and a 71% increase in marrow SLAM cells.
Molecular Weight

412.59

Formula

C₂₁H₂₀N₂OS₃

CAS No.

459147-39-8

SMILES

NC1=C(S(CCCC)=O)SC2=NC(C3=CC=CS3)=CC(C4=CC=CC=C4)=C21

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 50 mg/mL (121.19 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.4237 mL 12.1186 mL 24.2371 mL
5 mM 0.4847 mL 2.4237 mL 4.8474 mL
10 mM 0.2424 mL 1.2119 mL 2.4237 mL
*Please refer to the solubility information to select the appropriate solvent.
References

Purity: 99.62%

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Keywords:

SW033291SW 033291SW-03329115-PGDH15-Hydroxyprostaglandin dehydrogenasePeripheralneutrophilknockoutprostaglandinPGE2hematopoieticbonemarrowInhibitorinhibitorinhibit

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SW033291
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HY-16968
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