Immune Checkpoint Proteins
The immune checkpoint (ICP) molecules refer to ligand-receptor pairs that exert inhibitory or stimulatory effects on immune responses. Most of the ICP proteins that have been described are expressed on cells of the adaptive immune system, particularly on T cells, and of the innate immune system. ICPs act as important immune regulators in maintaining immune homeostasis and preventing autoimmunity.
Some cancer cells can bind co-inhibitory receptor molecules to limit normal anti-tumor immune responses, thus assisting in immune escape. Immune checkpoint therapy for cancer encompasses strategies that target these regulatory pathways to reinvigorate the anti-tumor function of immune cells. The most widely studied inhibitory checkpoint pathway consisting of cytotoxic T lymphocyte-associated molecule-4 (CTLA-4), programmed cell death receptor-1 (PD-1), and programmed cell death ligand-1 (PD-L1).
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Immune Checkpoint Recombinant Proteins (699)
- Species:
- Source:
Recombinant Protein Expression Service
- Codon Optimization
- Gene Synthesis
- Construction of Expression Vector
- Strain Screening
- Protein Expression
- Purification & QC
- Protein Delivery
- Formula: Human
- Molecular Weight: Sf9 insect cells
The EpCAM/TROP1 protein serves as an important homogeneous interacting molecule that promotes direct contact between intestinal epithelial cells (IEC) and intraepithelial lymphocytes (IEL) in the mucosal epithelium. This feature helps establish an immune barrier against mucosal infections. EpCAM/TROP1 Protein, Human (His-SUMO) is the recombinant human-derived EpCAM/TROP1 protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag.
