DDR1/CD167a
DDR1/CD167a is a receptor tyrosine kinase encoded by the DDR1 gene that is activated not by soluble growth factors but by fibrillar and basement membrane collagens. Collagen binding induces slow, sustained receptor autophosphorylation, a kinetics distinct from classical RTK signaling that regulates cell adhesion, migration, matrix remodeling and inflammatory cytokine release. DDR1 contains an N-terminal discoidin domain responsible for collagen recognition and is expressed chiefly in epithelial cells, fibroblasts and cells of the immune and reproductive systems. DDR1 dysregulation has been implicated in renal and pulmonary fibrosis, atherosclerosis and carcinoma progression, and selective DDR1 inhibitors are in preclinical and early clinical development.
-
DDR1/CD167a Recombinant Proteins (12)
-
Inhibitors & Agonists (21)
DDR1 Protein, Human (HEK293, His)
0 Images
Cat. No.: HY-P75305
Purity: ≥ 95%, as determined by reducing SDS-PAGE or Bis-Tris PAGE.
Synonyms: DDR1; HGK2; Prev. EDDR1; Neurotrophic Tyrosine Kinase, Receptor, Type 4; Prev. NTRK4; Discoidin Domain Receptor Family, Member 1; Prev. PTK3A; Epithelial Discoidin Domain Receptor 1; Prev. CAK; PTK3A Protein Tyrosine Kinase 3A; Prev. NEP; Receptor Protein
- Species:
- Source:
DDR1 Protein, Mouse (HEK293, His)
0 Images
Cat. No.: HY-P77639
Purity: ≥ 95%, as determined by Bis-Tris PAGE.
Synonyms: DDR1; HGK2; Prev. EDDR1; Neurotrophic Tyrosine Kinase, Receptor, Type 4; Prev. NTRK4; Discoidin Domain Receptor Family, Member 1; Prev. PTK3A; Epithelial Discoidin Domain Receptor 1; Prev. CAK; PTK3A Protein Tyrosine Kinase 3A; Prev. NEP; Receptor Protein
- Species:
- Source:
DDR1 Protein, Rat (HEK293, His)
0 Images
Cat. No.: HY-P75299
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: DDR1; HGK2; Prev. EDDR1; Neurotrophic Tyrosine Kinase, Receptor, Type 4; Prev. NTRK4; Discoidin Domain Receptor Family, Member 1; Prev. PTK3A; Epithelial Discoidin Domain Receptor 1; Prev. CAK; PTK3A Protein Tyrosine Kinase 3A; Prev. NEP; Receptor Protein
- Species:
- Source:
DDR1 Protein, Mouse (HEK293, His, solution)
0 Images
Cat. No.: HY-P75302
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: DDR1; HGK2; Prev. EDDR1; Neurotrophic Tyrosine Kinase, Receptor, Type 4; Prev. NTRK4; Discoidin Domain Receptor Family, Member 1; Prev. PTK3A; Epithelial Discoidin Domain Receptor 1; Prev. CAK; PTK3A Protein Tyrosine Kinase 3A; Prev. NEP; Receptor Protein
- Species:
- Source:
DDR1 Protein, Human (HEK293, Fc)
0 Images
Cat. No.: HY-P704093
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: DDR1; HGK2; Prev. EDDR1; Neurotrophic Tyrosine Kinase, Receptor, Type 4; Prev. NTRK4; Discoidin Domain Receptor Family, Member 1; Prev. PTK3A; Epithelial Discoidin Domain Receptor 1; Prev. CAK; PTK3A Protein Tyrosine Kinase 3A; Prev. NEP; Receptor Protein
- Species:
- Source:
DDR1 Protein, Mouse (Active, sf9, His-GST)
0 Images
Cat. No.: HY-P75301
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: DDR1; HGK2; Prev. EDDR1; Neurotrophic Tyrosine Kinase, Receptor, Type 4; Prev. NTRK4; Discoidin Domain Receptor Family, Member 1; Prev. PTK3A; Epithelial Discoidin Domain Receptor 1; Prev. CAK; PTK3A Protein Tyrosine Kinase 3A; Prev. NEP; Receptor Protein
- Species:
- Source:
DDR1 Protein, Human (Active, sf9, His-GST)
0 Images
Cat. No.: HY-P75304
Purity: ≥ 80%, as determined by reducing SDS-PAGE.
Synonyms: DDR1; HGK2; Prev. EDDR1; Neurotrophic Tyrosine Kinase, Receptor, Type 4; Prev. NTRK4; Discoidin Domain Receptor Family, Member 1; Prev. PTK3A; Epithelial Discoidin Domain Receptor 1; Prev. CAK; PTK3A Protein Tyrosine Kinase 3A; Prev. NEP; Receptor Protein
- Species:
- Source:
DDR1 Protein, Rat (HEK293, hFc)
0 Images
Cat. No.: HY-P75300
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: DDR1; HGK2; Prev. EDDR1; Neurotrophic Tyrosine Kinase, Receptor, Type 4; Prev. NTRK4; Discoidin Domain Receptor Family, Member 1; Prev. PTK3A; Epithelial Discoidin Domain Receptor 1; Prev. CAK; PTK3A Protein Tyrosine Kinase 3A; Prev. NEP; Receptor Protein
- Species:
- Source:
DDR1 Protein, Mouse (HEK293, Fc)
0 Images
Cat. No.: HY-P75303
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: DDR1; HGK2; Prev. EDDR1; Neurotrophic Tyrosine Kinase, Receptor, Type 4; Prev. NTRK4; Discoidin Domain Receptor Family, Member 1; Prev. PTK3A; Epithelial Discoidin Domain Receptor 1; Prev. CAK; PTK3A Protein Tyrosine Kinase 3A; Prev. NEP; Receptor Protein
- Species:
- Source:
DDR1 Protein, Human (Biotinylated, HEK293, His-Avi)
0 Images
Cat. No.: HY-P705128
Purity: ≥ 95%, as determined by SDS-PAGE.
Synonyms: DDR1; HGK2; Prev. EDDR1; Neurotrophic Tyrosine Kinase, Receptor, Type 4; Prev. NTRK4; Discoidin Domain Receptor Family, Member 1; Prev. PTK3A; Epithelial Discoidin Domain Receptor 1; Prev. CAK; PTK3A Protein Tyrosine Kinase 3A; Prev. NEP; Receptor Protein-Tyrosine Kinase; RTK6; Neuroepithelial Tyrosine Kinase; Epithelial Discoidin Domain-Containing Receptor 1; Discoidin Domain Receptor DDR1e; CD167 Antigen-Like Family Member A; Discoidin Domain Receptor DDR1d; Tyrosine Kinase DDR; Protein-Tyrosine Kinase 3A; CD167; CD167a Antigen; Discoidin Receptor Tyrosine Kinase; MCK-10; Protein-Tyrosine Kinase RTK-6; MCK10; Mammary Carcinoma Kinase 10; TRK E; Tyrosine-Protein Kinase CAK; PTK3; Cell Adhesion Kinase; DDR; Discoidin Domain Receptor Tyrosine Kinase 1; TRKE
- Species:
- Source:
DDR1 Protein, Human (sf9)
0 Images
Cat. No.: HY-P705804
Purity: ≥ 85%, as determined by reducing SDS-PAGE.
Synonyms: DDR1; HGK2; Prev. EDDR1; Neurotrophic Tyrosine Kinase, Receptor, Type 4; Prev. NTRK4; Discoidin Domain Receptor Family, Member 1; Prev. PTK3A; Epithelial Discoidin Domain Receptor 1; Prev. CAK; PTK3A Protein Tyrosine Kinase 3A; Prev. NEP; Receptor Protein-Tyrosine Kinase; RTK6; Neuroepithelial Tyrosine Kinase; Epithelial Discoidin Domain-Containing Receptor 1; Discoidin Domain Receptor DDR1e; CD167 Antigen-Like Family Member A; Discoidin Domain Receptor DDR1d; Tyrosine Kinase DDR; Protein-Tyrosine Kinase 3A; CD167; CD167a Antigen; Discoidin Receptor Tyrosine Kinase; MCK-10; Protein-Tyrosine Kinase RTK-6; MCK10; Mammary Carcinoma Kinase 10; TRK E; Tyrosine-Protein Kinase CAK; PTK3; Cell Adhesion Kinase; DDR; Discoidin Domain Receptor Tyrosine Kinase 1; TRKE
- Species:
- Source:
DDR1 Protein, Human (Active, 433a.a, sf9, GST)
0 Images
Cat. No.: HY-P706032
Purity: ≥ 80%, as determined by reducing SDS-PAGE.
Synonyms: DDR1; HGK2; Prev. EDDR1; Neurotrophic Tyrosine Kinase, Receptor, Type 4; Prev. NTRK4; Discoidin Domain Receptor Family, Member 1; Prev. PTK3A; Epithelial Discoidin Domain Receptor 1; Prev. CAK; PTK3A Protein Tyrosine Kinase 3A; Prev. NEP; Receptor Protein-Tyrosine Kinase; RTK6; Neuroepithelial Tyrosine Kinase; Epithelial Discoidin Domain-Containing Receptor 1; Discoidin Domain Receptor DDR1e; CD167 Antigen-Like Family Member A; Discoidin Domain Receptor DDR1d; Tyrosine Kinase DDR; Protein-Tyrosine Kinase 3A; CD167; CD167a Antigen; Discoidin Receptor Tyrosine Kinase; MCK-10; Protein-Tyrosine Kinase RTK-6; MCK10; Mammary Carcinoma Kinase 10; TRK E; Tyrosine-Protein Kinase CAK; PTK3; Cell Adhesion Kinase; DDR; Discoidin Domain Receptor Tyrosine Kinase 1; TRKE
- Species:
- Source:
- 1
Recombinant Protein Expression Service
- Codon Optimization
- Gene Synthesis
- Construction of Expression Vector
- Strain Screening
- Protein Expression
- Purification & QC
- Protein Delivery
- 1
Capetin (28-54), human
0 Images
- Formula: Human
- Molecular Weight: Sf9 insect cells
The EpCAM/TROP1 protein serves as an important homogeneous interacting molecule that promotes direct contact between intestinal epithelial cells (IEC) and intraepithelial lymphocytes (IEL) in the mucosal epithelium. This feature helps establish an immune barrier against mucosal infections. EpCAM/TROP1 Protein, Human (His-SUMO) is the recombinant human-derived EpCAM/TROP1 protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag.
