2. Natural Products
  3. Terpenoids

Terpenoids

Terpenoids are one of the most diverse classes of natural products produced in different genera of plants, fungi, algae and sponges, derived from five-carbon isoprene units assembled and modified in thousands of ways. Most are multicyclic structures that differ from one another not only in functional groups but also in their basic carbon skeletons. They can be classified according to the number of isoprene units used: monoterpenes (C10), sesquiterpenes (C15), diterpenes (C20), triterpenes (C30) and others. These subclassifications can be further classified according to different skeletons. Terpenoids have many physiological activities, such as expectorant, cough relieving, wind-dispelling, perspiration, insect repelling and analgesia.

 

Terpenoids (1673):

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-B0015
    Paclitaxel 33069-62-4 99.97%
    Paclitaxel is a naturally occurring antineoplastic agent and stabilizes tubulin polymerization. Paclitaxel can cause both mitotic arrest and apoptotic cell death. Paclitaxel also induces autophagy.
    Paclitaxel
  • HY-15371
    Forskolin 66575-29-9 99.78%
    Forskolin (Coleonol) is a potent adenylate cyclase activator with an IC50 of 41 nM and an EC50 of 0.5 μM for type I adenylyl cyclase. Forskolin is also an inducer of intracellular cAMP formation. Forskolin induces differentiation of various cell types and activates pregnane X receptor (PXR) and FXR. Forskolin exerts a inotropic effect on the heart, and has platelet antiaggregatory and antihypertensive actions. Forskolin also induces autophagy.
    Forskolin
  • HY-13433
    Thapsigargin 67526-95-8 99.95%
    Thapsigargin, an endoplasmic reticulum (ER) stress inducer, is an inhibitor of microsomal Ca2+-ATPase. Thapsigargin efficiently inhibits coronavirus (HCoV-229E, MERS-CoV, SARS-CoV-2) replication in different cell types.
    Thapsigargin
  • HY-32735
    Triptolide 38748-32-2 99.86%
    Triptolide is a diterpenoid triepoxide extracted from the root of Tripterygium wilfordii with immunosuppressive, anti-inflammatory, antiproliferative and antitumour effects. Triptolide is a NF-κB activation inhibitor.
    Triptolide
  • HY-13067
    Celastrol 34157-83-0 99.90%
    Celastrol (Tripterine;Tripterin) is a proteasome inhibitor which potently and preferentially inhibits the chymotrypsin-like activity of a purified 20S proteasome with IC50 of 2.5 μM.
    Celastrol
  • HY-N2095
    Atractylone 6989-21-5
    Atractylone (Atractylon) is a sesquiterpenoid extracted from Atractylodis Rhizoma. Atractylone (Atractylon) alleviates influenza A virus (IAV)-induced lung injury via regulating the TLR7 signaling pathway, and acts as a promising agent for IAV treatment. Atractylone (Atractylon) inhibits the degranulation of mast cell and exhibits potential for the treatment of mast cell-mediated allergic reactions.
    Atractylone
  • HY-107315
    Alisol F 24-acetate 443683-76-9
    Alisol F 24-acetate is a triterpene compound that can be isolated from the rhizomes of Alisma orientalis. Alisol F 24-acetate inhibits the secretion of HBV surface antigen HBsAg and HBeAg with IC50 values of 7.7 µM and 5.1 µM. Alisol F 24-acetate has proapoptotic activity and can be used for cancer research.
    Alisol F 24-acetate
  • HY-111243
    Ganoderone A 873061-79-1
    Ganoderone A is a triterpene compound that can be isolated from the fruiting body of Ganoderma pfeifferi and Ganoderma calidophilum. Ganoderone A has antiviral activity against HSV with IC50 value of 0.3 µg/mL. Ganoderone A has potential applications in viral infections and tumors.
    Ganoderone A
  • HY-N0176
    Dihydroartemisinin 71939-50-9 99.03%
    Dihydroartemisinin is a potent anti-malaria agent.
    Dihydroartemisinin
  • HY-N0184
    Glycyrrhizic acid 1405-86-3 ≥98.0%
    Glycyrrhizic acid is a triterpenoid saponinl, acting as a direct HMGB1 antagonist, with anti-tumor, anti-diabetic activities.
    Glycyrrhizic acid
  • HY-N0193
    Artesunate 88495-63-0 98.09%
    Artesunate is an inhibitor of both STAT-3 and exported protein 1 (EXP1).
    Artesunate
  • HY-N0431
    Astragaloside IV 84687-43-4 ≥98.0%
    Astragaloside IV, an active component isolated from Astragalus membranaceus, suppresses the activation of ERK1/2 and JNK, and downregulates matrix metalloproteases (MMP)-2, (MMP)-9 in MDA-MB-231 breast cancer cells.
    Astragaloside IV
  • HY-N0004
    Oridonin 28957-04-2 99.89%
    Oridonin (NSC-250682), a diterpenoid isolated from Rabdosia rubescens, acts as an inhibitor of AKT, with IC50s of 8.4 and 8.9 μM for AKT1 and AKT2; Oridonin possesses anti-tumor, anti-bacterial and anti-inflammatory effects.
    Oridonin
  • HY-N0141
    Parthenolide 20554-84-1 98.54%
    Parthenolide is a sesquiterpene lactone found in the medicinal herb Feverfew. Parthenolide exhibits anti-inflammatory activity by inhibiting NF-κB activation; also inhibits HDAC1 protein without affecting other class I/II HDACs.
    Parthenolide
  • HY-19543
    Brusatol 14907-98-3 99.89%
    Brusatol (NSC 172924) is a unique inhibitor of the Nrf2 pathway that sensitizes a broad spectrum of cancer cells to Cisplatin and other chemotherapeutic agents. Brusatol enhances the efficacy of chemotherapy by inhibiting the Nrf2-mediated defense mechanism. Brusatol can be developed into an adjuvant chemotherapeutic agent. Brusatol increases cellular apoptosis.
    Brusatol
  • HY-10529
    Betulinic acid 472-15-1 ≥98.0%
    Betulinic acid is a natural pentacyclic triterpenoid, acts as a eukaryotic topoisomerase I inhibitor, with an IC50 of 5 μM, and possesses anti-HIV, anti-malarial, anti-inflammatory and anti-tumor properties.
    Betulinic acid
  • HY-B0094
    Artemisinin 63968-64-9 98.40%
    Artemisinin (Qinghaosu), a sesquiterpene lactone, is an anti-malarial agent isolated from the aerial parts of Artemisia annua L. plants. Artemisinin inhibits AKT signaling pathway by decreasing pAKT in a dose-dependent manner. Artemisinin reduces cancer cell proliferation, migration, invasion, tumorigenesis and metastasis and has neuroprotective effects.
    Artemisinin
  • HY-N0140
    Ursolic acid 77-52-1 99.66%
    Ursolic acid (Prunol) is a natural pentacyclic triterpenoid carboxylic acid, exerts anti-tumor effects and is an effective compound for cancer prevention and therapy.
    Ursolic acid
  • HY-101092
    QS-21 141256-04-4 99.20%
    QS-21, an immunostimulatory saponin, could be used as a potent vaccine adjuvant. QS-21 stimulates Th2 humoral and Th1 cell-mediated immune responses through action on antigen presenting cells (APCs) and T cells. QS-21 can activate the NLRP3 inflammasome with subsequent release of caspase-1 dependent cytokines, IL-1β and IL-18.
    QS-21
  • HY-N0156
    Oleanolic Acid 508-02-1 ≥98.0%
    Oleanolic acid (Caryophyllin) is a natural compound from plants with anti-tumor activities.
    Oleanolic Acid