VEGFR
The vascular endothelial growth factor (VEGF) family of receptors (VEGFR) consists of three protein-tyrosine kinases (VEGFR1, VEGFR2, and VEGFR3) and two non-protein kinase co-receptors (neuropilin-1 and neuropilin-2). VEGFRs are typical tyrosine kinase receptors (TKRs) consist of an extracellular component with seven immunoglobulin-like domains, a single transmembrane domain, and a split tyrosine kinase domain. VEGF-A, -B, and PlGF bind to VEGFR-1; VEGFR-2 is stimulated by VEGF-A, -C, -D and -E; VEGFR-3 is specific for VEGF-C and -D. According to the consensus model for ligand-induced activation of RTKs, VEGF binds to a cognate VEGFR to induce receptor dimerization, leading to protein kinase activation and autophosphorylation of tyrosine residues in the receptor intracellular domains, and initiation of signaling pathways, such as PI3K/AKT and MAPK/ERK1/2. VEGFR signaling is tightly regulated at numerous different levels, including receptor expression levels, the availability and affinities for binding of its different ligands, the presence of VEGF-binding co-receptors, non-VEGF-binding auxiliary proteins and inactivating tyrosine phosphatases, the rate of receptor cellular uptake, extent of degradation and speed of recycling.
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VEGFR Recombinant Proteins (36)
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Inhibitors & Agonists (807)
- Species:
- Source:
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Recombinant Protein Expression Service
- Codon Optimization
- Gene Synthesis
- Construction of Expression Vector
- Strain Screening
- Protein Expression
- Purification & QC
- Protein Delivery
- 1
- 2
- Formula: Human
- Molecular Weight: Sf9 insect cells
The EpCAM/TROP1 protein serves as an important homogeneous interacting molecule that promotes direct contact between intestinal epithelial cells (IEC) and intraepithelial lymphocytes (IEL) in the mucosal epithelium. This feature helps establish an immune barrier against mucosal infections. EpCAM/TROP1 Protein, Human (His-SUMO) is the recombinant human-derived EpCAM/TROP1 protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag.
