MASP-1
MASP-1 (mannose-binding lectin-associated serine protease 1, encoded by MASP1) is one of two proteases that associate with mannose-binding lectin complexes in plasma. Produced as a zymogen, MASP-1 is the most abundant lectin-pathway protease and acts first in the activation cascade: upon MBL binding to microbial carbohydrates, MASP-1 autoactivates and then transactivates MASP-2, while it can also directly cleave C2 and, to a limited extent, C3. Beyond complement, MASP-1 contributes to coagulation through factor XIII and thrombin-activatable fibrinolysis inhibitor cleavage, and MASP-1/3 isoforms from the same gene are essential for alternative pathway priming. MASP-1 inhibitors are being explored for ischemia-reperfusion and inflammatory conditions.
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MASP-1 Recombinant Proteins (3)
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Recombinant Protein Expression Service
- Codon Optimization
- Gene Synthesis
- Construction of Expression Vector
- Strain Screening
- Protein Expression
- Purification & QC
- Protein Delivery
- Formula: Human
- Molecular Weight: Sf9 insect cells
The EpCAM/TROP1 protein serves as an important homogeneous interacting molecule that promotes direct contact between intestinal epithelial cells (IEC) and intraepithelial lymphocytes (IEL) in the mucosal epithelium. This feature helps establish an immune barrier against mucosal infections. EpCAM/TROP1 Protein, Human (His-SUMO) is the recombinant human-derived EpCAM/TROP1 protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag.
