2. Oligonucleotides
  3. Polymers

Polymers

The utility of polymers to function as intracellular delivery systems for nucleic acids has been studied for several decades. For instance, cationic polymers are able to condense nucleic acids into polyplexes via electrostatic interactions, enhancing cellular uptake and endosome escape. Notably, the physiochemical properties of polymers (charge, degradability and molecular weight) can be carefully adjusted through bottom-up chemical synthesis. Up to now, cyclodextrin polymer (CDP)-based nanoparticles have entered clinical trials for siRNA delivery.

Polymers (29):

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-112735
    Hexadimethrine bromide 28728-55-4 99.69%
    Hexadimethrine bromide (Polybrene) is a cationic polymer used routinely to enhance the efficiency of retrovirus vector-mediated gene transfer.
    Hexadimethrine bromide
  • HY-B2247
    PLGA (50:50) 34346-01-5 99.31%
    PLGA (50:50) (poly(lactic-co-glycolic acid) (50:50)) is a copolymer of poly lactic acid (PLA) and poly glycolic acid (PGA) which can be used to fabricate devices for drug delivery and tissue engineering applications.
    PLGA (50:50)
  • HY-B0633A
    Hyaluronic acid 9004-61-9
    Hyaluronic acid (corn fermented) is a biopolymer composed of repeating units of disaccharides with various applications.
    Hyaluronic acid
  • HY-135969
    Glycol chitosan 123938-86-3
    Glycol chitosan is a chitosan derivative with ethylene glycol branches. Glycol chitosan enhances membrane permeability and leadkage in Glycine max Harosoy 63W cells. Glycol chitosan is biocompatible and biodegradable. Glycol chitosan inhibits E. coli, S. aureus and S. enteritidis growths with MIC values of 4 μg/mL, 32 μg/mL and <0.5 μg/mL, respectively.
    Glycol chitosan
  • HY-D1005A
    Poloxamer 188 9003-11-6
    Poloxamer 188 is a nonionic linear copolymer with surfactant properties. Poloxamer 188 exhibits anti-thrombotic, anti-inflammatory, and cytoprotective activities in various tissue injury models. Poloxamer 188 can be used for drug delivery.
    Poloxamer 188
  • HY-D1005H
    Poloxamer 188 (F68) 9003-11-6
    Poloxamer 188 is a nonionic linear copolymer with surfactant properties. Poloxamer 188 exhibits anti-thrombotic, anti-inflammatory, and cytoprotective activities in various tissue injury models.
    Poloxamer 188 (F68)
  • HY-Y0850E
    Polyvinyl alcohol (Mw 30000-70000, 87-90% hydrolyzed) 9002-89-5
    Polyvinyl alcohol (Mw 30000-70000, 87-90% hydrolyzed) is a polyvinyl alcohol with a molecular weight of 30000-70000 and hydrolytic properties. The degree of hydrolysis refers to the degree to which the acetate groups in the original polyvinyl acetate are converted into hydroxyl groups during the hydrolysis process. Polyvinyl alcohol (Mw 30000-70000, 87-90% hydrolyzed) is the hydrolysis and removal of acetate groups after the polymerization of ethylene acetate. And polyvinyl alcohol is obtained. A degree of hydrolysis of 87-90% indicates that a large part of the acetate groups have been removed, resulting in a large number of hydroxyl groups in the PVA structure. Polyvinyl alcohol with different degrees of hydrolysis can be used to self-crosslink to form cryogel, which can be used as biological excipients.
    Polyvinyl alcohol (Mw 30000-70000, 87-90% hydrolyzed)
  • HY-Y0850H
    Polyvinyl alcohol (Mw 89000-98000, 99+% hydrolyzed) 9002-89-5
    Polyvinyl alcohol (Mw 89000-98000, 99+% hydrolyzed) also known as PVA, is a vinyl water-soluble polymer that can be used as a non-ionic surfactant. It can also be used as a biodegradable polymer and can be used in adhesives, coatings, textiles, ceramics and cosmetics.
    Polyvinyl alcohol (Mw 89000-98000, 99+% hydrolyzed)
  • HY-B2247A
    PLGA (75:25) 34346-01-5 99.12%
    PLGA (75:25) is a low toxicity, biocompatible and biodegradable controlled drug delivery carrier, can achieve slow release in the organism. PLGA (75:25) is a copolymer of 75% poly lactic acid (PLA) and 25% poly glycolic acid (PGA). PLGA (75:25) has been extensively studied as delivery vehicles for agents, proteins and various other macromolecules such as DNA, RNA and peptides.
    PLGA (75:25)
  • HY-112624
    Dextran 9004-54-0
    Dextran (Dextran 40) has an inhibitory effect on thrombocyte aggregation and coagulation factors and is used as a plasma volume expander.
    Dextran
  • HY-126437A
    Poly-L-lysine hydrochloride 26124-78-7
    Poly-L-lysine hydrochloride is a nonspecific attachment factor for cells useful in promoting cell adhesion to solid substrates by enhancing electrostatic interaction between negatively charged ions of the cell membrane and the culture surface. Poly-L-lysine hydrochloride is a strong-attraction regulator that promotes liquid-liquid phase separation (LLPS) at low concentrations but suppresses LLPS at high concentrations. Antibacterial cationic peptide..
    Poly-L-lysine hydrochloride
  • HY-112624B
    Dextran (MW 70000) 9004-54-0
    Dextran (MW 70000) is a complex carbohydrate polymer consisting of glucose molecules linked by glycosidic bonds. Dextran has excellent solubility in water, making it useful as a viscosity modifier or stabilizer in foods, paints and adhesives. In the biomedical field, dextran is often used as a plasma expander because of its ability to increase blood volume when administered intravenously. It can also be modified to create dextran-based drug delivery systems, such as targeted nanoparticles.
    Dextran (MW 70000)
  • HY-148033
    Trimethyl chitosan 52349-26-5
    Trimethyl chitosan (N,N,N-Trimethylchitosan) is a water-soluble multifunctional polymer which is a Chitosan (HY-B2144A) derivative. Trimethyl chitosan can be used for drug delivery and to synthesize nanoparticles.
    Trimethyl chitosan
  • HY-W243303A
    Poly(acrylic acid) (MW 2000) 9003-01-4
    Poly(acrylic acid) is a polyacrylic acid with a molecular weight of 2000.
    Poly(acrylic acid) (MW 2000)
  • HY-112624C
    Dextran (MW 40000) 9004-54-0
    Dextran (MW 40000) is a complex carbohydrate polymer consisting of glucose molecules linked by glycosidic bonds. Dextran has excellent solubility in water, making it useful as a viscosity modifier or stabilizer in foods, paints and adhesives. In the biomedical field, dextran is often used as a plasma expander because of its ability to increase blood volume when administered intravenously. It can also be modified to create dextran-based drug delivery systems, such as targeted nanoparticles.
    Dextran (MW 40000)
  • HY-W243303E
    Poly(acrylic acid) (MW 450000) 9003-01-4
    Poly(acrylic acid) (MW 450000) is a polyacrylic acid with a molecular weight of 450000. Poly(acrylic acid) (MW 450000) is an anionic polymer. Poly(acrylic acid) (MW 450000) can be as a corrosion-mitigating and surface-stabilizing agent.
    Poly(acrylic acid) (MW 450000)
  • HY-126437
    Poly-L-lysine hydrobromide (MW 30000-70000) 25988-63-0
    Poly-L-lysine hydrobromide (MW 30000-70000) is a water-soluble synthetic polypeptide.
    Poly-L-lysine hydrobromide (MW 30000-70000)
  • HY-145396
    PLGA-PEG-NH2 ≥98.0%
    PLGA-PEG-NH2 is a material to synthesis nanomicelles. PLGA-PEG-NH2 nanomicelle is an efficient delivery system of Irinotecan for targeted colorectal cancer and hepatocellular carcinoma.
    PLGA-PEG-NH2
  • HY-148775
    PLGA-PEG-MAL (60kDA-3.4kDA, LA:GA ratio 75:25)
    PLGA-PEG-MAL (60kDA-3.4kDA, LA:GA ratio 75:25) is a kind of poly(lactide-co-glycolide)-block-poly(ethylene glycol) (PLGA-PEG-Mal) nanoparticles. PLGA-PEG-MAL (60kDA-3.4kDA, LA:GA ratio 75:25) has a molecular weight of 60kDA to 3.4kDA and contains a 75:25 ratio of lactic acid (LA) to glycolic acid (GA) molecules.
    PLGA-PEG-MAL (60kDA-3.4kDA, LA:GA ratio 75:25)
  • HY-148776
    PLGA-PEG-MAL (20kDA-5.0kDA, LA:GA ratio 50:50)
    PLGA-PEG-MAL (20kDA-5.0kDA, LA:GA ratio 50:50) is a kind of poly(lactide-co-glycolide)-block-poly(ethylene glycol) (PLGA-PEG-Mal) nanoparticles. PLGA-PEG-MAL (20kDA-5.0kDA, LA:GA ratio 50:50) has a molecular weight of 20kDA to 5.0kDA and contains a 50:50 ratio of lactic acid (LA) to glycolic acid (GA) molecules. The molecular ratio of LA to GA determines the rate of matrix degradation and protein re-release.
    PLGA-PEG-MAL (20kDA-5.0kDA, LA:GA ratio 50:50)