2. Oligonucleotides
  3. Polymers

Polymers

The utility of polymers to function as intracellular delivery systems for nucleic acids has been studied for several decades. For instance, cationic polymers are able to condense nucleic acids into polyplexes via electrostatic interactions, enhancing cellular uptake and endosome escape. Notably, the physiochemical properties of polymers (charge, degradability and molecular weight) can be carefully adjusted through bottom-up chemical synthesis. Up to now, cyclodextrin polymer (CDP)-based nanoparticles have entered clinical trials for siRNA delivery.

Polymers (9):

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-112735
    Hexadimethrine bromide 28728-55-4
    Hexadimethrine bromide (Polybrene) is a cationic polymer used routinely to enhance the efficiency of retrovirus vector-mediated gene transfer.
    Hexadimethrine bromide
  • HY-B0633A
    Hyaluronic acid 9004-61-9
    Hyaluronic acid (corn fermented) is a biopolymer composed of repeating units of disaccharides with various applications.
    Hyaluronic acid
  • HY-B2247
    PLGA (50:50) 34346-01-5 99.22%
    PLGA (50:50) (poly(lactic-co-glycolic acid) (50:50)) is a copolymer of poly lactic acid (PLA) and poly glycolic acid (PGA) which can be used to fabricate devices for drug delivery and tissue engineering applications.
    PLGA (50:50)
  • HY-135969
    Glycol chitosan 123938-86-3
    Glycol chitosan is a chitosan derivative with ethylene glycol branches. Glycol chitosan enhances membrane permeability and leadkage in Glycine max Harosoy 63W cells. Glycol chitosan is biocompatible and biodegradable. Glycol chitosan inhibits E. coli, S. aureus and S. enteritidis growths with MIC values of 4 μg/mL, 32 μg/mL and <0.5 μg/mL, respectively.
    Glycol chitosan
  • HY-112624
    Dextran 9004-54-0
    Dextran (Dextran 40) has an inhibitory effect on thrombocyte aggregation and coagulation factors and is used as a plasma volume expander.
    Dextran
  • HY-145396
    PLGA-PEG-NH2 ≥98.0%
    PLGA-PEG-NH2 is a material to synthesis nanomicelles. PLGA-PEG-NH2 nanomicelle is an efficient delivery system of Irinotecan for targeted colorectal cancer and hepatocellular carcinoma.
    PLGA-PEG-NH2
  • HY-126437A
    Poly-L-lysine hydrochloride 26124-78-7
    Poly-L-lysine hydrochloride is a nonspecific attachment factor for cells useful in promoting cell adhesion to solid substrates by enhancing electrostatic interaction between negatively charged ions of the cell membrane and the culture surface. Poly-L-lysine hydrochloride is a strong-attraction regulator that promotes liquid-liquid phase separation (LLPS) at low concentrations but suppresses LLPS at high concentrations. Antibacterial cationic peptide..
    Poly-L-lysine hydrochloride
  • HY-144027
    Dolichol (13~21) 153857-77-3
    Dolichol (13~21) is a lipid carrier containing isoprene units. Dolichol (13~21) can be used for liposomes applied in drug delivery.
    Dolichol (13~21)
  • HY-126437
    Poly-L-lysine hydrobromide (MW 30000-70000) 25988-63-0
    Poly-L-lysine hydrobromide (MW 30000-70000) is a water-soluble synthetic polypeptide.
    Poly-L-lysine hydrobromide (MW 30000-70000)