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Hexadimethrine bromide (Synonyms: 1,5-Dimethyl-1,5-diazaundecamethylene polymethobromide)

Cat. No.: HY-112735 Purity: >97.0%
Handling Instructions

Hexadimethrine bromide is a cationic polymer discovered to enhance retroviral transduction.

For research use only. We do not sell to patients.

Hexadimethrine bromide Chemical Structure

Hexadimethrine bromide Chemical Structure

CAS No. : 28728-55-4

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Based on 3 publication(s) in Google Scholar

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Description

Hexadimethrine bromide is a cationic polymer discovered to enhance retroviral transduction.

In Vitro

Hexadimethrine bromide inhibits human mesenchymal stem cell proliferation during lentiviral transduction. Hexadimethrine bromide is considered non-toxic at low concentrations, but has been found to negatively affect cell proliferation in some cell types at concentrations greater than 10 µg/mL. Trypsinized cells exposed to Hexadimethrine bromide are visibly larger in size when viewed under the microscope[1].

Formula

(C₁₃H₃₀N₂)n.Br₂

CAS No.

28728-55-4

SMILES

C[N+](CCCCCCC)(C)CCC[N+](C)(C)C.[Br-].[Br-].[n]

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, stored under nitrogen, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen, away from moisture)

Solvent & Solubility
In Vitro: 

H2O : ≥ 125 mg/mL

DMSO : 5 mg/mL (Need ultrasonic and warming)

*"≥" means soluble, but saturation unknown.

In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 0.5 mg/mL (Infinity mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 0.5 mg/mL (Infinity mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: 0.5 mg/mL (Infinity mM); Clear solution; Need warming

*All of the co-solvents are provided by MCE.
References
Cell Assay
[1]

Trypsinized cells are washed and resuspended in medium at 2×104 cells/mL with or without rhFGF-2 (final concentration=10 ng/mL, PeproTech) and with or without Hexadimethrine bromide at a final Hexadimethrine bromide concentration of 1, 4, or 8 µg/mL. The different conditions are seeded in 96-well plates at 1×103 cells in 50 µL per well in triplicate and cultured at 37°C, 5% CO2. After 6, 9, or 24 hr, the medium is changed and subsequent medium changes occurred every 3-4 days with 50 µL of ± FGF-2 medium (10 ng/mL). Plates are harvested on day 4, 7, 14, and 21 by removing the medium and placing the plates in the -80°C freezer until the day of analysis. The CyQUANT assay is then performed on the wells[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

References

Purity: >97.0%

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Keywords:

Hexadimethrine1,5-Dimethyl-1,5-diazaundecamethylene polymethobromideOthersInhibitorinhibitorinhibit

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Product Name:
Hexadimethrine bromide
Cat. No.:
HY-112735
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