Hexadimethrine bromide
Based on 114 publication(s) in Google Scholar
Hexadimethrine bromide (Polybrene) is a cationic polymer used routinely to enhance the efficiency of retrovirus vector-mediated gene transfer.
For research use only. We do not sell to patients.
- CAS No.: 28728-55-4
- Formula: (C13H30N2Br2)n.
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Storage:
4°C, stored under nitrogen, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
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Biological Activity
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Chemical Information
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Publications Citing Use of MedChemExpress (MCE) Hexadimethrine bromide
More- Signal Transduct Target Ther. 2024 Mar 4;9(1):58. [Abstract]
- Science. 2026 Jan 22;391(6783):eadv5257. [Abstract]
- Cell. 2025 Jun 26;188(13):3405-3421.e27. [Abstract]
- Cell Res. 2026 Jan 7. [Abstract]
- Cancer Commun (Lond). 2025 May 29. [Abstract]
- Mil Med Res. 2023 Jul 25;10(1):34. [Abstract]
- Cell Stem Cell. 2026 Apr 2;33(4):660-675.e5. [Abstract]
- Cell Stem Cell. 2025 Dec 4;32(12):1849-1868.e15. [Abstract]
- Adv Funct Mater. 2025 May 22.
- Adv Funct Mater. 2019, 1808556.
- Nat Protoc. 2025 Oct 8. [Abstract]
- Nat Commun. 2025 Sep 30;16(1):8642. [Abstract]
- Nat Commun. 2025 Aug 7;16(1):7309. [Abstract]
- Nat Commun. 2024 May 17;15(1):4195. [Abstract]
- Nat Commun. 2023 Oct 23;14(1):6690. [Abstract]
- Nat Commun. 2023 May 2;14(1):2523. [Abstract]
- Bone Res. 2025 Mar 3;13(1):30. [Abstract]
- Trends Biotechnol. 2025 Oct 22:S0167-7799(25)00365-8. [Abstract]
- J Extracell Vesicles. 2024 Nov;13(11):e70002. [Abstract]
- Autophagy. 2026 May 22:1-17. [Abstract]
- Autophagy. 2025 Oct 14:1-23. [Abstract]
- Autophagy. 2025 Feb;21(2):424-446. [Abstract]
- Adv Sci (Weinh). 2026 Mar 12:e21931. [Abstract]
- Adv Sci (Weinh). 2025 Feb 3:e2403851. [Abstract]
- Adv Sci (Weinh). 2024 Dec 25:e2406822. [Abstract]
- Adv Sci (Weinh). 2022 Aug;9(22):e2104823. [Abstract]
- J Exp Clin Cancer Res. 2025 Nov 24;45(1):1. [Abstract]
- J Control Release. 2025 Sep 30;388(Pt 1):114283. [Abstract]
- Environ Sci Technol. 2025 Dec 23;59(50):27143-27155. [Abstract]
- Cell Death Dis. 2025 Oct 6;16(1):703. [Abstract]
- Cell Death Dis. 2025 Jun 17;16(1):452. [Abstract]
- Cell Death Dis. 2025 May 19;16(1):400. [Abstract]
- Acta Biomater. 2025 Apr 10:S1742-7061(25)00265-X. [Abstract]
- Proc Natl Acad Sci U S A. 2023 Jan 31;120(5):e2208960120. [Abstract]
- Cell Commun Signal. 2025 Aug 5;23(1):365. [Abstract]
- Cell Commun Signal. 2024 Apr 2;22(1):211. [Abstract]
- Int J Biol Macromol. 2025 Dec 3;337(Pt 1):149421. [Abstract]
- Acta Pharmacol Sin. 2025 Jun 23. [Abstract]
- EMBO Mol Med. 2025 Oct 15. [Abstract]
- J Transl Med. 2021 Mar 23;19(1):123. [Abstract]
- Biomed Pharmacother. 2020 Jan;121:109578. [Abstract]
- Oncogene. 2024 Jul;43(28):2143-2159. [Abstract]
- Cell Rep. 2025 Aug 26;44(8):116099. [Abstract]
- Cell Rep. 2025 Jun 13;44(6):115851. [Abstract]
- Microbiol Res. 2024 May:282:127659. [Abstract]
- Clin Transl Med. 2025 Dec;15(12):e70554. [Abstract]
- Clin Transl Med. 2023 Sep;13(9):e1410. [Abstract]
- Cell Mol Life Sci. 2025 Apr 6;82(1):139. [Abstract]
- Transl Res. 2023 Sep:259:62-71. [Abstract]
- Chin Med. 2025 Nov 14;20(1):189. [Abstract]
- Biochem Pharmacol. 2026 Jan;243(Pt 2):117557. [Abstract]
- Biochem Pharmacol. 2025 Oct 17;243(Pt 1):117433. [Abstract]
- Chem Biol Interact. 2026 Apr 28:112112. [Abstract]
- J Ethnopharmacol. 2025 Feb 10;338(Pt 1):119006. [Abstract]
- Life Sci. 2026 Mar 15:389:124244. [Abstract]
- Commun Biol. 2025 Jul 29;8(1):1127. [Abstract]
- Life Sci. 2022 Mar 15:293:120320. [Abstract]
- Int J Mol Sci. 2026 Feb 13;27(4):1807. [Abstract]
- Biol Direct. 2025 Oct 1;20(1):100. [Abstract]
- Int J Oncol. 2024 Apr;64(4):45. [Abstract]
- Front Pharmacol. 2021 Mar 8:12:603453. [Abstract]
- mBio. 2026 Apr 8;17(4):e0008126. [Abstract]
- Int Immunopharmacol. 2026 Mar 15:173:116306. [Abstract]
- Int Immunopharmacol. 2025 Aug 26:164:115417. [Abstract]
- Int Immunopharmacol. 2025 Jul 30:163:115268. [Abstract]
- Int Immunopharmacol. 2024 Nov 16;143(Pt 3):113622. [Abstract]
- Am J Physiol Cell Physiol. 2024 Oct 1;327(4):C1125-C1142. [Abstract]
- Int Immunopharmacol. 2024 Jun 24:138:112518. [Abstract]
- Cell Rep Methods. 2024 Aug 27:100843. [Abstract]
- Cancers (Basel). 2024 Jan 12;16(2):336. [Abstract]
- Biomed J. 2024 Jun;47(3):100651. [Abstract]
- Poult Sci. 2024 Dec 5;104(1):104633. [Abstract]
- Transl Oncol. 2024 Aug 24:49:102081. [Abstract]
- Sci Rep. 2026 May 20. [Abstract]
- Sci Rep. 2025 Jul 2;15(1):22578. [Abstract]
- Biomedicines. 2023 Jul 24;11(7):2077. [Abstract]
- Mol Cell Biochem. 2025 Dec 1. [Abstract]
- Cell Signal. 2019 Jun:58:119-130. [Abstract]
- Heliyon. 2024 Aug 29;10(17):e37137. [Abstract]
- Mol Med Rep. 2026 Apr;33(4):103. [Abstract]
- Viruses. 2024 Dec 18;16(12):1932. [Abstract]
- Cell Adh Migr. 2024 Dec;18(1):38-53. [Abstract]
- BMC Cancer. 2024 Jan 2;24(1):14. [Abstract]
- Front Oncol. 2022 Jun 13;12:817660. [Abstract]
- Mol Carcinog. 2025 Nov 18. [Abstract]
- Mol Carcinog. 2025 Oct 18. [Abstract]
- Pathol Res Pract. 2025 Apr 17:270:155982. [Abstract]
- Pathol Res Pract. 2025 May:269:155902. [Abstract]
- Hum Cell. 2025 Jul 3;38(5):123. [Abstract]
- Hum Cell. 2025 Apr 19;38(3):92. [Abstract]
- Ren Fail. 2026 Dec;48(1):2657652. [Abstract]
- Discov Oncol. 2024 Sep 15;15(1):449. [Abstract]
- J Immunother. 2025 Feb-Mar;48(2):46-57. [Abstract]
- Epigenomics. 2026 Feb;18(2):155-168. [Abstract]
- Theriogenology. 2025 Jan 30:236:21-32. [Abstract]
- J Neuroimmunol. 2023 Apr 15:377:578065. [Abstract]
- Odontology. 2026 Mar 20. [Abstract]
- Exp Ther Med. 2023 Apr 13;25(6):248. [Abstract]
- Oncol Lett. 2023 Mar 8;25(4):167. [Abstract]
- Arch Oral Biol. 2025 Oct 26:181:106442. [Abstract]
- J Gastrointest Oncol. 2022 Jun;13(3):1255-1265. [Abstract]
- Scand J Immunol. 2024 Apr 26:e13371. [Abstract]
- Braz J Med Biol Res. 2025 Mar 3:58:e14187. [Abstract]
- J Int Med Res. 2021 May;49(5):3000605211009722. [Abstract]
- STAR Protoc. 2025 Mar 10;6(1):103685. [Abstract]
- bioRxiv. 2025 Aug 31:2025.08.28.672283. [Abstract]
- SSRN. 2025 Sep 19.
- bioRxiv. 2025 Sep 18:2025.09.15.676412. [Abstract]
- bioRxiv. 2025 Jul 24:2025.07.23.666448. [Abstract]
- SSRN. 2025 Jan 24.
- bioRxiv. 2025 Jul 8:2025.01.09.631916. [Abstract]
- bioRxiv. 2024 Jul 22:2023.09.14.557413. [Abstract]
- Research Square Preprint. 2023 Jun 23.
- Research Square Print. 2023 Jan.
Biological Activity
Hexadimethrine bromide inhibits human mesenchymal stem cell proliferation during lentiviral transduction. Hexadimethrine bromide is considered non-toxic at low concentrations, but has been found to negatively affect cell proliferation in some cell types at concentrations greater than 10 μg/mL. Trypsinized cells exposed to Hexadimethrine bromide are visibly larger in size when viewed under the microscope[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 28728-55-4
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Appearance Solid
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Formula (C13H30N2Br2)n.
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Color White to off-white
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SMILES
C[N+](CCCCCCC)(C)CCC[N+](C)(C)C.[Br-].[Br-].[n]
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Synonyms
Polybrene; 1,5-Dimethyl-1,5-diazaundecamethylene polymethobromide
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, stored under nitrogen, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen, away from moisture)
Publications (114)
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Journal Impact Factor
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Most Recent
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Signal Transduct Target Ther
Suppression of ITPKB degradation by Trim25 confers TMZ resistance in glioblastoma through ROS homeostasis. [Abstract]2024 Mar 4;9(1):58. PMID: 38438346 -
Science
Endogenous retroviruses synthesize heterologous chimeric RNAs to reinforce human early embryo development. [Abstract]2026 Jan 22;391(6783):eadv5257. PMID: 41570148 -
Cell
Extrachromosomal DNA replication and maintenance couple with DNA damage pathway in tumors. [Abstract]2025 Jun 26;188(13):3405-3421.e27. PMID: 40300601 -
Cell Res
Sensing of DNA double-strand breaks by the NHEJ system stabilizes RORγt transcriptional activity and shapes Th17 pathogenicity in autoimmunity. [Abstract]2026 Jan 7. PMID: 41495483 -
Cancer Commun (Lond)
Simvastatin overcomes the pPCK1-pLDHA-SPRINGlac axis-mediated ferroptosis and chemo-immunotherapy resistance in AKT-hyperactivated intrahepatic cholangiocarcinoma. [Abstract]2025 May 29. PMID: 40443016 -
Mil Med Res
RARRES2 regulates lipid metabolic reprogramming to mediate the development of brain metastasis in triple negative breast cancer. [Abstract]2023 Jul 25;10(1):34. PMID: 37491281 -
Cell Stem Cell
2026 Apr 2;33(4):660-675.e5. PMID: 41895281 -
Cell Stem Cell
Injury-induced Clusterin+ cardiomyocytes suppress inflammation and promote regeneration in neonatal and adult hearts by reprogramming macrophages. [Abstract]2025 Dec 4;32(12):1849-1868.e15. PMID: 41205597 -
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Nat Protoc
Inducible CRISPR-Cas9 screening platform to interrogate non-proliferative cellular states. [Abstract]2025 Oct 8. PMID: 41062702 -
Nat Commun
Inhibition of ICAM1 diminishes stemness and enhances antitumor immunity in glioblastoma via β-catenin/PD-L1 signaling. [Abstract]2025 Sep 30;16(1):8642. PMID: 41028719 -
Nat Commun
RIPK1 kinase drove brain microvascular endothelial cells death and blood-brain barrier disruption in neonatal Escherichia coli meningitis. [Abstract]2025 Aug 7;16(1):7309. PMID: 40774959 -
Nat Commun
Ferritinophagy mediates adaptive resistance to EGFR tyrosine kinase inhibitors in non-small cell lung cancer. [Abstract]2024 May 17;15(1):4195. PMID: 38760351 -
Nat Commun
The liver microenvironment orchestrates FGL1-mediated immune escape and progression of metastatic colorectal cancer. [Abstract]2023 Oct 23;14(1):6690. PMID: 37872170 -
Nat Commun
Reduced hepatic bradykinin degradation accounts for cold-induced BAT thermogenesis and WAT browning in male mice. [Abstract]2023 May 2;14(1):2523. PMID: 37130842 -
Bone Res
Enhanced SIRT3 expression restores mitochondrial quality control mechanism to reverse osteogenic impairment in type 2 diabetes mellitus. [Abstract]2025 Mar 3;13(1):30. PMID: 40025004 -
Trends Biotechnol
2025 Oct 22:S0167-7799(25)00365-8. PMID: 41130838 -
J Extracell Vesicles
A switch from lysosomal degradation to secretory autophagy initiates osteogenic bone metastasis in prostate cancer. [Abstract]2024 Nov;13(11):e70002. PMID: 39497621 -
Autophagy
USF2 restricts enterovirus replication and transmission by inhibiting autophagy and vesicle-mediated viral spread. [Abstract]2026 May 22:1-17. PMID: 42152487 -
Autophagy
2025 Oct 14:1-23. PMID: 41037659 -
Autophagy
MLKL-USP7-UBA52 signaling is indispensable for autophagy in brain through maintaining ubiquitin homeostasis. [Abstract]2025 Feb;21(2):424-446. PMID: 39193909 -
Adv Sci (Weinh)
Cryoablation Activates the cGAS-STING-CXCL10 Axis in Macrophages to Enhance Anti-Tumor Immunity in NSCLC. [Abstract]2026 Mar 12:e21931. PMID: 41818612 -
Adv Sci (Weinh)
Excessive MYC Orchestrates Macrophages induced Chromatin Remodeling to Sustain Micropapillary-Patterned Malignancy in Lung Adenocarcinoma. [Abstract]2025 Feb 3:e2403851. PMID: 39899538 -
Adv Sci (Weinh)
ShK-modified UCMSCs Inhibit M1-Like Macrophage Polarization and Alleviate Osteoarthritis Progression via PI3K/Akt Axis. [Abstract]2024 Dec 25:e2406822. PMID: 39721037 -
Adv Sci (Weinh)
A Temporal PROTAC Cocktail-Mediated Sequential Degradation of AURKA Abrogates Acute Myeloid Leukemia Stem Cells. [Abstract]2022 Aug;9(22):e2104823. PMID: 35652200 -
J Exp Clin Cancer Res
GSTK1 suppresses HCC aggravation via L-carnitine metabolism by PGAM5/DRP1 complex-mediated mitochondrial quality control. [Abstract]2025 Nov 24;45(1):1. PMID: 41276823 -
J Control Release
Targeting polyamine metabolism induces oxidative/carbonyl stress to reinvigorate antitumor immunity in prostate cancer. [Abstract]2025 Sep 30;388(Pt 1):114283. PMID: 41038348 -
Environ Sci Technol
Establishing a Genetically Stable COS7-RXRα Cell Model for Screening Emerging Contaminants with RXRα Modulatory Effects. [Abstract]2025 Dec 23;59(50):27143-27155. PMID: 41381359 -
Cell Death Dis
The deubiquitinase USP9X and E3 ligase WWP1 orchestrate IGF2BP2 ubiquitination homeostasis to drive TNBC progression and cisplatin sensitivity. [Abstract]2025 Oct 6;16(1):703. PMID: 41053085 -
Cell Death Dis
Repurposing MDM2 inhibitor RG7388 for TP53-mutant NSCLC: a p53-independent pyroptotic mechanism via ROS/p-p38/NOXA/caspase-3/GSDME axis. [Abstract]2025 Jun 17;16(1):452. PMID: 40523886 -
Cell Death Dis
Synergistic regulation of DACH1 stability by acetylation and deubiquitination promotes colorectal cancer progression. [Abstract]2025 May 19;16(1):400. PMID: 40389405 -
Acta Biomater
Engineered bioorthogonal cell delivery system for in situ antimicrobial peptide recruitment during systemic bacterial infection. [Abstract]2025 Apr 10:S1742-7061(25)00265-X. PMID: 40220946 -
Proc Natl Acad Sci U S A
Destabilizing NF1 variants act in a dominant negative manner through neurofibromin dimerization. [Abstract]2023 Jan 31;120(5):e2208960120. PMID: 36689660 -
Cell Commun Signal
Wnt5a suppresses colorectal cancer progression via TGF-β/NOTUM/OLFM4 axis in patient-derived organoids. [Abstract]2025 Aug 5;23(1):365. PMID: 40765051 -
Cell Commun Signal
EP300-ZNF384 transactivates IL3RA to promote the progression of B-cell acute lymphoblastic leukemia. [Abstract]2024 Apr 2;22(1):211. PMID: 38566191 -
Int J Biol Macromol
17-AAG promotes the degradation of HSP90 client METTL3 to suppress MYC RNA m6A modification and expression in colorectal cancer. [Abstract]2025 Dec 3;337(Pt 1):149421. PMID: 41349747 -
Acta Pharmacol Sin
Ginsenoside (20)S-APPT induces ferroptosis in hepatocellular carcinoma and cholangiocarcinoma by targeting FSP1. [Abstract]2025 Jun 23. PMID: 40550962 -
EMBO Mol Med
Isoginkgetin antagonizes ALS pathologies in its animal and patient iPSC models via PINK1-Parkin-dependent mitophagy. [Abstract]2025 Oct 15. PMID: 41094045 -
J Transl Med
A circular RNA derived from PLXNB2 as a valuable predictor of the prognosis of patients with acute myeloid leukaemia. [Abstract]2021 Mar 23;19(1):123. PMID: 33757550 -
Biomed Pharmacother
CA8 promotes RCC proliferation and migration though its expression level is lower in tumor compared to adjacent normal tissue. [Abstract]2020 Jan;121:109578. PMID: 31715371 -
Oncogene
Epstein-Barr virus causes vascular abnormalities in epithelial malignancies through upregulating ANXA3-HIF-1α-VEGF pathway. [Abstract]2024 Jul;43(28):2143-2159. PMID: 38778160 -
Cell Rep
NRCAM variant defined by microexon skipping is a targetable cell surface proteoform in high-grade gliomas. [Abstract]2025 Aug 26;44(8):116099. PMID: 40782352 -
Cell Rep
ENPP1 governs the metabolic regulation of effector T cells in autoimmunity by detecting cytosolic mitochondrial DNA. [Abstract]2025 Jun 13;44(6):115851. PMID: 40516055 -
Microbiol Res
SARS-CoV-2 Membrane protein regulates the function of Spike by inhibiting its plasma membrane localization and enzymatic activity of Furin. [Abstract]2024 May:282:127659. PMID: 38430890 -
Clin Transl Med
Exosomal miR-3126-5p derived from cancer-associated fibroblasts facilitates glycolysis to accelerate NSCLC progression by targeting KLF13 to activate the SH2B1/IRS1 axis. [Abstract]2025 Dec;15(12):e70554. PMID: 41410190 -
Clin Transl Med
Long noncoding RNA Regulating ImMune Escape regulates mixed lineage leukaemia protein-1-H3K4me3-mediated immune escape in oesophageal squamous cell carcinoma. [Abstract]2023 Sep;13(9):e1410. PMID: 37712124 -
Cell Mol Life Sci
Single-cell transcriptomics reveals liver developmental trajectory during lineage reprogramming of human induced hepatocyte-like cells. [Abstract]2025 Apr 6;82(1):139. PMID: 40188417 -
Transl Res
2023 Sep:259:62-71. PMID: 37121538 -
Chin Med
Corynoline enhances sorafenib sensitivity in hepatocellular carcinoma via NOS3-mediated ROS production. [Abstract]2025 Nov 14;20(1):189. PMID: 41233831 -
Biochem Pharmacol
TRPC6 inhibition by Z3571: A structure-based strategy to ameliorate glomerular and tubular dysfunction in chronic kidney disease. [Abstract]2026 Jan;243(Pt 2):117557. PMID: 41276089 -
Biochem Pharmacol
E3 ubiquitin ligase WSB1-mediated ubiquitination modification of DIO2 promotes colorectal cancer stemness and metastasis by blocking thyroid hormone signaling. [Abstract]2025 Oct 17;243(Pt 1):117433. PMID: 41110484 -
Chem Biol Interact
A novel HDAC1-Hcy/Glu-ferroptosis axis underlies valproic acid-induced hepatic steatosis. [Abstract]2026 Apr 28:112112. PMID: 42061694 -
J Ethnopharmacol
Qihuang Zhuyu formula modulates mitochondrial function to inhibit platelet activation via endocannabinoid signaling mediated by the SIRT1/PPARα pathway. [Abstract]2025 Feb 10;338(Pt 1):119006. PMID: 39500463 -
Life Sci
Lactate promotes cuproptosis in acute kidney injury by activating H3K18 lactylation-dependent upregulation of HSPA6 expression. [Abstract]2026 Mar 15:389:124244. PMID: 41616844 -
Commun Biol
Pantothenic acid ameliorates hepatic fibrosis by targeting IGFBP6 to regulate the TGF-β/SMADs pathway. [Abstract]2025 Jul 29;8(1):1127. PMID: 40730679 -
Life Sci
KIR2DL4 promotes the proliferation of RCC cell associated with PI3K/Akt signaling activation. [Abstract]2022 Mar 15:293:120320. PMID: 35063466 -
Int J Mol Sci
KIF18B Is Essential for Lung Adenocarcinoma Progression Through the E2F Transcriptional Network. [Abstract]2026 Feb 13;27(4):1807. PMID: 41751942 -
Biol Direct
MINPP1 promotes ferroptosis in HBV-related hepatocellular carcinoma by regulating CTSB K33-linked deubiquitination via ZRANB1. [Abstract]2025 Oct 1;20(1):100. PMID: 41035046 -
Int J Oncol
Lysine methyltransferase 5C increases the proliferation and metastatic abilities of clear cell renal cell carcinoma via aerobic glycolysis. [Abstract]2024 Apr;64(4):45. PMID: 38426605 -
Front Pharmacol
2021 Mar 8:12:603453. PMID: 33762936 -
mBio
2026 Apr 8;17(4):e0008126. PMID: 41773863 -
Int Immunopharmacol
Methamphetamine regulates microglial polarization and glycolytic activity to promote Parkinson's disease through the LIPH/LPA/PI3K/AKT signaling axis. [Abstract]2026 Mar 15:173:116306. PMID: 41628513 -
Int Immunopharmacol
VCPIP1 ameliorates sepsis-associated encephalopathy by promoting microglia autophagy via the PI3K/AKT/mTOR pathway. [Abstract]2025 Aug 26:164:115417. PMID: 40865405 -
Int Immunopharmacol
METTL3-mediated MSRB3 m6A modification accelerates hypoxia-induced cardiomyocyte ferroptosis by inhibiting mitochondrial oxidative phosphorylation. [Abstract]2025 Jul 30:163:115268. PMID: 40743621 -
Int Immunopharmacol
VCPIP1 negatively regulates NF-κB signaling pathways by deubiquitinating and stabilizing Erbin in MDP-stimulated macrophages. [Abstract]2024 Nov 16;143(Pt 3):113622. PMID: 39550842 -
Am J Physiol Cell Physiol
Hypomethylation-associated ELF3 helps nasopharyngeal carcinoma to escape immune surveillance via MUC16-mediated glycolytic metabolic reprogramming. [Abstract]2024 Oct 1;327(4):C1125-C1142. PMID: 39219440 -
Int Immunopharmacol
Targeting lipid peroxidation-associated ferroptosis suppresses lung carcinoma progression by regulating cell cycle arrest. [Abstract]2024 Jun 24:138:112518. PMID: 38917528 -
Cell Rep Methods
2024 Aug 27:100843. PMID: 39216483 -
Cancers (Basel)
2024 Jan 12;16(2):336. PMID: 38254825 -
Biomed J
Long noncoding RNA TUG1 promotes malignant progression of osteosarcoma by enhancing ZBTB7C expression. [Abstract]2024 Jun;47(3):100651. PMID: 37562773 -
Poult Sci
2024 Dec 5;104(1):104633. PMID: 39693965 -
Transl Oncol
Transcriptional regulation of DLGAP5 by AR suppresses p53 signaling and inhibits CD8+T cell infiltration in triple-negative breast cancer. [Abstract]2024 Aug 24:49:102081. PMID: 39182361 -
Sci Rep
Establishment of an immortalized erythroid model for Hb Bart's hydrops fetalis with homozygous α0-thalassemia Southeast Asian deletion. [Abstract]2026 May 20. PMID: 42162272 -
Sci Rep
2025 Jul 2;15(1):22578. PMID: 40594054 -
Biomedicines
CD44 Is Associated with Poor Prognosis of ccRCC and Facilitates ccRCC Cell Migration and Invasion through HAS1/MMP9. [Abstract]2023 Jul 24;11(7):2077. PMID: 37509716 -
Mol Cell Biochem
Deubiquitinase OTUD5 facilitates stiffness-induced hepatic stellate cell activation by stabilizing YAP. [Abstract]2025 Dec 1. PMID: 41324862 -
Cell Signal
2019 Jun:58:119-130. PMID: 30849520 -
Heliyon
The S341P mutant MYOC renders the trabecular meshwork sensitive to cyclic mechanical stretch. [Abstract]2024 Aug 29;10(17):e37137. PMID: 39286096 -
Mol Med Rep
Integrative bioinformatics and experimental analysis reveals FRA1 as a key mediator of tubulointerstitial inflammation in lupus nephritis. [Abstract]2026 Apr;33(4):103. PMID: 41614421 -
Viruses
Development and Evaluation of a Newcastle Disease Virus-like Particle Vaccine Expressing SARS-CoV-2 Spike Protein with Protease-Resistant and Stability-Enhanced Modifications. [Abstract]2024 Dec 18;16(12):1932. PMID: 39772238 -
Cell Adh Migr
Fe3O4 nanoparticles containing gambogic acid inhibit metastasis in colorectal cancer via the RORB/EMILIN1 axis. [Abstract]2024 Dec;18(1):38-53. PMID: 39533963 -
BMC Cancer
A hsa_circ_001726 axis regulated by E2F6 contributes to metastasis of hepatocellular carcinoma. [Abstract]2024 Jan 2;24(1):14. PMID: 38166853 -
Front Oncol
The Specifically Androgen-Regulated Gene (SARG) Promotes Papillary Thyroid Carcinoma (PTC) Lymphatic Metastasis Through Vascular Endothelial Growth Factor C (VEGF-C) and VEGF Receptor 3 (VEGFR-3) Axis. [Abstract]2022 Jun 13;12:817660. PMID: 35769717 -
Mol Carcinog
KDM6A Exhibits Antitumor Activities Toward Ovarian Cancer by Epigenetically Activating Transcription of ISG-15. [Abstract]2025 Nov 18. PMID: 41252674 -
Mol Carcinog
2025 Oct 18. PMID: 41108787 -
Pathol Res Pract
Moderate exercise relieves heart failure-induced skeletal muscle atrophy through the inhibition of MAPK/SOCS3 signaling. [Abstract]2025 Apr 17:270:155982. PMID: 40286786 -
Pathol Res Pract
M2 macrophages-derived exosomal MDH1 drives lung adenocarcinoma progression via the Hippo/YAP signaling. [Abstract]2025 May:269:155902. PMID: 40090126 -
Hum Cell
CircTADA2A inhibits cell proliferation and promotes ferroptosis by sponging miR-638 in acute myeloid leukemia. [Abstract]2025 Jul 3;38(5):123. PMID: 40608154 -
Hum Cell
Hyaluronic acid-modified milk exosomes carrying ZNF516 inhibit ABCC5 and contribute to pemetrexed sensitivity in lung adenocarcinoma. [Abstract]2025 Apr 19;38(3):92. PMID: 40253507 -
Ren Fail
Curcumin regulates ferroptosis by activating α7 nicotinic acetylcholine receptor to improve sepsis-induced acute kidney injury. [Abstract]2026 Dec;48(1):2657652. PMID: 42015821 -
Discov Oncol
2024 Sep 15;15(1):449. PMID: 39278863 -
J Immunother
NUSAP1 Promotes Immunity and Apoptosis by the SHCBP1/JAK2/STAT3 Phosphorylation Pathway to Induce Dendritic Cell Generation in Hepatocellular Carcinoma. [Abstract]2025 Feb-Mar;48(2):46-57. PMID: 38980111 -
Epigenomics
E2F1-driven cholesterol synthesis via the SND1/ACLY axis potentiates malignant progression in prostate cancer. [Abstract]2026 Feb;18(2):155-168. PMID: 41588650 -
Theriogenology
2025 Jan 30:236:21-32. PMID: 39893798 -
J Neuroimmunol
A novel rare variant of CNPY3 from familial NMOSD impairs the TLR-mediated immune response. [Abstract]2023 Apr 15:377:578065. PMID: 36931208 -
Odontology
E2F2 suppresses cell senescence and promotes odontogenic differentiation in dental pulp stem cells by stabilizing METTL3. [Abstract]2026 Mar 20. PMID: 41860675 -
Exp Ther Med
Role of p53 in promoting BMP9‑induced osteogenic differentiation of mesenchymal stem cells through TGF‑β1. [Abstract]2023 Apr 13;25(6):248. PMID: 37153899 -
Oncol Lett
Transcriptomic analysis of the effects of the HPV18 E6E7 gene on the cell death mode in esophageal squamous cell carcinoma. [Abstract]2023 Mar 8;25(4):167. PMID: 36960186 -
Arch Oral Biol
NFIC activates DEPTOR and blocks mTOR signaling to inhibit glycolysis and immune escape in oral squamous cell carcinoma. [Abstract]2025 Oct 26:181:106442. PMID: 41176831 -
J Gastrointest Oncol
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Solvent & Solubility
H2O : 100 mg/mL (Need ultrasonic)
DMSO : 5 mg/mL (Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 0.5 mg/mL; Clear solution
This protocol yields a clear solution of ≥ 0.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (5.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 0.5 mg/mL; Clear solution
This protocol yields a clear solution of ≥ 0.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (5.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
For the following dissolution methods, please prepare the working solution directly:
It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: PBS
Solubility: 100 mg/mL; Clear solution; Need ultrasonic
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Working solution concentration: 0.22 mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
Protocol
Trypsinized cells are washed and resuspended in medium at 2×104 cells/mL with or without rhFGF-2 (final concentration=10 ng/mL, PeproTech) and with or without Hexadimethrine bromide at a final Hexadimethrine bromide concentration of 1, 4, or 8 µg/mL. The different conditions are seeded in 96-well plates at 1×103 cells in 50 µL per well in triplicate and cultured at 37°C, 5% CO2. After 6, 9, or 24 hr, the medium is changed and subsequent medium changes occurred every 3-4 days with 50 µL of ± FGF-2 medium (10 ng/mL). Plates are harvested on day 4, 7, 14, and 21 by removing the medium and placing the plates in the -80°C freezer until the day of analysis. The CyQUANT assay is then performed on the wells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Purity & Documentation
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Data Sheet (268 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Hexadimethrine bromide Related Classifications
HY-112735 Related Classifications
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