1. Metabolic Enzyme/Protease
  2. Cytochrome P450

Cytochrome P450

Cytochrome p450 comprises a superfamily of heme-thiolate proteins named for the spectral absorbance peak of their carbon-monoxide-bound species at 450 nm. Having been found in every class of organism, including Archaea, the p450 superfamily is believed to have originated from an ancestral gene that existed over 3 billion years ago. Repeated gene duplications have subsequently given rise to one of the largest of multigene families. These enzymes are notable both for the diversity of reactions that they catalyze and the range of chemically dissimilar substrates upon which they act. Cytochrome p450s support the oxidative, peroxidative and reductive metabolism of such endogenous and xenobiotic substrates as environmental pollutants, agrochemicals, plant allelochemicals, steroids, prostaglandins and fatty acids. In humans, Cytochrome p450s are best known for their central role in phase I drug metabolism where they are of critical importance to two of the most significant problems in clinical pharmacology: drug interactions and interindividual variability in drug metabolism.

Cytochrome P450 Related Products (43):

Cat. No. Product Name Effect Purity
  • HY-14531
    Talarozole Inhibitor 99.57%
    Talarozole is a potent inhibitor of both CYP26A1 and CYP26B1, with IC50 of 0.46 nM and 5.1 nM for CYP26B1 and CYP26A1, respectively.
  • HY-75054
    Abiraterone acetate Inhibitor 99.92%
    Abiraterone acetate is an oral, potent, selective, and irreversible inhibitor of CYP17.
  • HY-70013
    Abiraterone Inhibitor 99.31%
    Abiraterone is a potent, selective, and irreversible CYP17 inhibitor with IC50 of 2 to 4 nM.
  • HY-12451
    FICZ 98.19%
    FICZ(6-Formylindolo[3,2-b]carbazole) is a tryptophan-derived, high affinity Ah receptor ligand; efficient inducer of CYP1A1 gene expression in short time incubation (0.5 h) experiments.
  • HY-10493
    Cobicistat Inhibitor >98.0%
    Cobicistat is a potent, and selective inhibitor of cytochrome P450 3A (CYP3A) enzymes with IC50 of 30-285 nM.
  • HY-B0105
    Ketoconazole Inhibitor 99.76%
    Ketoconazole is an imidazole anti-fungal agent, a CYP3A4 and CYP24A1 inhibitor.
  • HY-16785
    Veledimex Inhibitor 99.09%
    Veledimex is an oral activator ligand for a proprietary gene therapy promoter system, and a moderate inhibitor of and substrate for CYP3A4/5.
  • HY-16785A
    Veledimex racemate
    Veledimex racemate is the racemate of veledimex.
  • HY-17356
    Fenofibrate Inhibitor 99.92%
    Fenofibrate is a relatively potent inhibitor of CYP2C19 (IC50=0.2 μM) and CYP2B6 (IC50=0.7 μM).
  • HY-70006
    TOK-001 Inhibitor 99.14%
    TOK-001 is a multifunctional antiandrogen and CYP17 inhibitor (IC50=47 nM) in castration resistant prostate cancer (CRPC).
  • HY-B0365A
    Memantine hydrochloride Inhibitor >98.0%
    Memantine, an amantadine derivative with low to moderate-affinity for NMDA receptors, inhibit CYP2B6 and CYP2D6 with Ki of 0.51 nM and 94.9 μM, respectively.
  • HY-17508
    Clarithromycin Inhibitor >98.0%
    Clarithromycin is a macrolide antibiotic and a CYP3A4 inhibitor.
  • HY-15996
    VT-464 Inhibitor 98.98%
    VT-464 is a potent CYP17 lyase inhibitor(h-Lyase IC50=69 nM) that demonstrated both exceptional in vitro lyase/hydroxylase selectivity (~10-fold) and oral activity in a hamster model of androgen biosynthesis inhibition.
  • HY-B1311
    Proadifen hydrochloride Inhibitor >98.0%
    Proadifen hydrochloride is a Cytochrome P450 inhibitor (IC50 = 19μM).
  • HY-10505
    Orteronel Inhibitor 99.75%
    Orteronel(TAK-700) was selected as a candidate for clinical evaluation.
  • HY-76316
    Bergaptol Inhibitor 99.28%
    Bergaptol A hydroxylated psoralen that acts as a potent inhibitors of debenzylation activity of CYP3A4 enzyme with an IC50 value of 24.92 uM.
  • HY-14273
    Isavuconazole Inhibitor 99.99%
    Isavuconazole is a moderate inhibitor of CYP3A4 and a water-soluble triazole with broad-spectrum antifungal activity.
  • HY-B1232
    Metyrapone Inhibitor >98.0%
    Metyrapone is an inhibitor of cytochrome P450-mediated ω/ω-1 hydroxylase activity and CYP11B1.
  • HY-N0153
    Naringin Inhibitor 99.50%
    Naringin is a major flavanone glycoside obtained from tomatoes, grapefruits, and many other citrus fruits.
  • HY-30151
    Methoxsalen Inhibitor 99.99%
    Methoxsalen (8-Methoxypsoralen) is a potent tricyclic furocoumarin suicide inhibitor of CYP (cytochrome P-450), is an agent used to treat psoriasis, eczema, vitiligo and some cutaneous Lymphomas in conjunction with exposing the skin to sunlight.