1. NF-κB
    Autophagy
  2. IKK
    Autophagy

Apigenin (Synonyms: 4',5,7-Trihydroxyflavone; Apigenine; Apigenol; C.I. Natural Yellow 1)

Cat. No.: HY-N1201 Purity: >98.0%
Data Sheet SDS Handling Instructions

Apigenin is a non-toxic and non-mutagenic flavone that exists abundantly in numerous herbs and vegetables.

For research use only. We do not sell to patients.
Apigenin Chemical Structure

Apigenin Chemical Structure

CAS No. : 520-36-5

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10 mM * 1 mL in DMSO USD 66 In-stock
10 mg USD 60 In-stock
50 mg USD 78 In-stock
100 mg USD 132 In-stock
200 mg USD 192 In-stock
500 mg USD 288 In-stock
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Customer Review

Other Forms of Apigenin:

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  • Technical Information

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  • References

Description

Apigenin is a non-toxic and non-mutagenic flavone that exists abundantly in numerous herbs and vegetables. IC50 value: Target: In vitro: Apigenin reduced viability and migratory properties, increased apoptosis, and suppressed mitochondrial membrane potential in both the JAR and JEG3 cells. In addition, apigenin predominantly decreased phosphorylation of AKT, P70RSK and S6 whereas the phosphorylation of ERK1/2 and P90RSK was increased by apigenin treatment of JAR and JEG3 cells in a dose-dependent manner. Moreover, treatment of JAR and JEG3 cells with both apigenin and pharmacological inhibitors of PI3K/AKT (LY294002) and ERK1/2 (U0126) revealed synergistic anti-proliferative effects [1]. In vivo:Using NF-κB luciferase transgenic mice, we found that apigenineffectively modulated NF-κB activity in the lungs, suggesting the ability of dietary compounds to exert immune-regulatory activity in an organ-specific manner [2]. In rabbit articular chondrocytes, apigenin inhibited the gene expression of MMP-3, MMP-1, MMP-13, ADAMTS-4, and ADAMTS-5. Furthermore, apigenin inhibited production of MMP-3 protein in vivo [3].

References
Molecular Weight

270.24

Formula

C₁₅H₁₀O₅

CAS No.

520-36-5

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Shipping

Room temperature in continental US; may vary elsewhere

Solvent & Solubility

DMSO: ≥ 30 mg/mL

* "<1 mg/mL" means slightly soluble or insoluble. "≥" means soluble, but saturation unknown.

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Apigenin
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