1. Cell Cycle/DNA Damage
    PI3K/Akt/mTOR
  2. ATM/ATR

ATM/ATR

ATM/ATR are members of the PI3 family of serine-threonine kinases and function as essential links between the sensors and effectors of the DNA damage response. The roles of ATM and ATR partially overlap and are cooperative; however they are also known to play distinct roles in protecting the cell from DNA damage. ATM is mostly responsible for sending signals from DSBs (double-strand breaks) induced by ionizing radiation while the closely related ATR responds to UV damage or stalled replication forks. ATM and ATR are known to phosphorylate common as well as specific substrates to activate checkpoint signaling. The G1, S, and G2 cell cycle checkpoints are primarily regulated by the ATM (ataxia telangiectasia, mutated) and ATR (ATM and Rad3-related) protein kinases.

ATM/ATR Related Products (12):

Cat. No. Product Name Effect Purity
  • HY-10197
    Wortmannin Inhibitor
    Wortmannin is a multi-target inhibitor of PI3K and MLCK with IC50s of 3 nM and 170 nM, respectively.
  • HY-19323
    AZD6738 Inhibitor
    AZD6738 is a potent inhibitor of ATR kinase activity with an IC50 of 1 nM against the isolated enzyme and 74 nM against ATR kinase-dependent CHK1 phosphorylation in cells.
  • HY-14731
    VE-821 Inhibitor
    VE-821 is a potent ATP-competitive inhibitor of ATR with Ki/IC50 of 13 nM/26 nM.
  • HY-12016
    KU-55933 Inhibitor
    KU-55933 is a potent ATM inhibitor with an IC50 and Ki of 12.9 and 2.2 nM, respectively, and highly selective for ATM as compared to DNA-PK, PI3K/PI4K, ATR and mTOR.
  • HY-13902
    VE-822 Inhibitor
    VE-822 is an ATR inhibitor with Ki value of <0.2 nM, also inhibits ATM with Ki of 34 nM.
  • HY-12061
    KU-60019 Inhibitor
    KU-60019 is an improved ATM kinase-specific inhibitor with IC50 of 6.3 nM.
  • HY-100016
    AZD0156 Inhibitor
    AZD0156 is an orally active, potent and selective ATM kinase inhibitor, used for cancer treatment.
  • HY-11002
    CP-466722 Inhibitor
    CP-466722 is rapidly reversible potential ATM kinase inhibitor.
  • HY-15520
    CGK733 Inhibitor
    CGK 733 is a small molecule inhibitor reportedly targeting the kinase activities of ATM and ATR.
  • HY-15557
    AZ20 Inhibitor
    AZ20 is a potent and selective inhibitor of ATR with an IC50 of 5 nM, and has 8-fold selectivity against mTOR (IC50=38 nM).
  • HY-16667
    HLM006474 Inhibitor
    HLM006474 is a potent inhibitor of melanocytes proliferation and subsequent invasion in a three-dimensional tissue culture model system; interferes with E2F activity.
  • HY-15521
    ETP-46464 Inhibitor
    ETP-46464 is a cell-permeable quinoline-containing heterotricyclic compound that acts as a potent inhibitor against mTOR, ATR, DNA-PK, PI 3-K(alpha), and ATM (IC50= 0.6, 14, 36, 170, and 545 nM, respectively).