1. Cell Cycle/DNA Damage PI3K/Akt/mTOR Apoptosis
  2. ATM/ATR Apoptosis
  3. (Z)-Mirin

(Z)-Mirin 

Cat. No.: HY-19959 Purity: 99.30%
COA Handling Instructions

(Z)-Mirin is an MRN (Mre11-Rad50-Nbs1) inhibitor. (Z)-Mirin prevents MRN-dependent activation of ATM without affecting ATM protein kinase activity. (Z)-Mirin inhibits Mre11-associated exonuclease activity. (Z)-Mirin increases apoptosis, triggers a G2/M checkpoint and strongly inhibits homology-directed repair (HDR).

For research use only. We do not sell to patients.

(Z)-Mirin Chemical Structure

(Z)-Mirin Chemical Structure

CAS No. : 1198097-97-0

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10 mM * 1 mL in DMSO
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Based on 4 publication(s) in Google Scholar

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Description

(Z)-Mirin is an MRN (Mre11-Rad50-Nbs1) inhibitor. (Z)-Mirin prevents MRN-dependent activation of ATM without affecting ATM protein kinase activity. (Z)-Mirin inhibits Mre11-associated exonuclease activity. (Z)-Mirin increases apoptosis, triggers a G2/M checkpoint and strongly inhibits homology-directed repair (HDR)[1][2].

In Vitro

(Z)-Mirin (50, 100, 500 μM) inhibits ATM-dependent phosphorylation of Nbs1 and Chk2 and the MRN-dependent autophosphorylation of ATM at Ser1981 in response to DNA double-strand breaks (DSBs). (Z)-Mirin (100 μM) inhibits Mre11 nuclease activity[1].
(Z)-Mirin (10-100 μM; 24 h) shows 50% cytotoxicity at 50 μM in HEK293 cells[1].
(Z)-Mirin (10-100 μM) induces a substantial G2 arrest at concentrations of 50 μM and 100 μM[1].
(Z)-Mirin (18 µM; 48 h) increases apoptosis in PEO4 cells[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Cytotoxicity Assay[1]

Cell Line: Human embryonic kidney (HEK) 293 cells
Concentration: 10, 25, 50, 100 μM
Incubation Time: 24 h
Result: Had little effect on cell survival at 25 μM and showed 50% cytotoxicity at 50 μM.

Cell Cycle Analysis[1]

Cell Line: TOSA4 cells
Concentration: 10, 25, 50, 100 μM
Incubation Time:
Result: Induced a substantial G2 arrest at concentrations of 50 μM and 100 μM.

Apoptosis Analysis[2]

Cell Line: PEO4 cells
Concentration: 18 µM
Incubation Time: 48 h
Result: Increased apoptosis.
Molecular Weight

220.25

Formula

C10H8N2O2S

CAS No.
Appearance

Solid

Color

Light yellow to yellow

SMILES

O=C1N=C(N)S/C1=C\C2=CC=C(O)C=C2

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 2 years
-20°C 1 year
Solvent & Solubility
In Vitro: 

DMSO : ≥ 31 mg/mL (140.75 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 4.5403 mL 22.7015 mL 45.4030 mL
5 mM 0.9081 mL 4.5403 mL 9.0806 mL
10 mM 0.4540 mL 2.2701 mL 4.5403 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% Saline

    Solubility: ≥ 1 mg/mL (4.54 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in Saline)

    Solubility: ≥ 1 mg/mL (4.54 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% Corn Oil

    Solubility: ≥ 1 mg/mL (4.54 mM); Clear solution

*All of the co-solvents are available by MedChemExpress (MCE).
Purity & Documentation

Purity: 99.30%

References
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(Z)-Mirin Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Product Name:
(Z)-Mirin
Cat. No.:
HY-19959
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