ErbB3/HER3
ErbB3 (HER3) is an unusual ERBB family member whose kinase domain is catalytically impaired but whose extracellular region binds neuregulins with the highest affinity in the family. Upon neuregulin engagement, HER3 heterodimerizes chiefly with HER2, and the partner kinase drives robust PI3K-AKT signaling through ERBB3's characteristic docking tyrosines. Frequent HER3 upregulation contributes to resistance against EGFR and HER2 targeted therapies. Patritumab deruxtecan, an HER3-directed antibody-drug conjugate, has advanced in lung and breast cancer trials, sustaining interest in recombinant ERBB3 reagents. Gene mutations in ERBB3 occur across cancers, and HER3 levels are being evaluated as pharmacodynamic biomarkers in neuregulin-driven settings.
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ErbB3/HER3 Recombinant Proteins (15)
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Inhibitors & Agonists (23)
HER3 Protein, Human (HEK293, Fc)
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Cat. No.: HY-P70322
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: ERBB3; Receptor Protein-Tyrosine Kinase; Prev. LCCS2; P45-SErbB3; HER3; P85-SErbB3; V-Erb-B2 Avian Erythroblastic Leukemia Viral Oncogene Homolog 3; ErbB-3 R31; Tyrosine Kinase-Type Cell Surface Receptor HER3; MDA-BF-1; Human Epidermal Growth Factor Recep
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HER3 Protein, Human (HEK293, His)
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Cat. No.: HY-P72625
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: ERBB3; Receptor Protein-Tyrosine Kinase; Prev. LCCS2; P45-SErbB3; HER3; P85-SErbB3; V-Erb-B2 Avian Erythroblastic Leukemia Viral Oncogene Homolog 3; ErbB-3 R31; Tyrosine Kinase-Type Cell Surface Receptor HER3; MDA-BF-1; Human Epidermal Growth Factor Recep
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HER3 Protein, Human (Biotinylated, HEK293, His-Avi)
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Cat. No.: HY-P72375
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: ERBB3; Receptor Protein-Tyrosine Kinase; Prev. LCCS2; P45-SErbB3; HER3; P85-SErbB3; V-Erb-B2 Avian Erythroblastic Leukemia Viral Oncogene Homolog 3; ErbB-3 R31; Tyrosine Kinase-Type Cell Surface Receptor HER3; MDA-BF-1; Human Epidermal Growth Factor Recep
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HER3 Protein, Human (312a.a, HEK293, Fc)
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Cat. No.: HY-P70323
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: ERBB3; Receptor Protein-Tyrosine Kinase; Prev. LCCS2; P45-SErbB3; HER3; P85-SErbB3; V-Erb-B2 Avian Erythroblastic Leukemia Viral Oncogene Homolog 3; ErbB-3 R31; Tyrosine Kinase-Type Cell Surface Receptor HER3; MDA-BF-1; Human Epidermal Growth Factor Recep
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HER3 Protein, Human (Biotinylated, HEK293, Fc)
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Cat. No.: HY-P74894
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: ERBB3; Receptor Protein-Tyrosine Kinase; Prev. LCCS2; P45-SErbB3; HER3; P85-SErbB3; V-Erb-B2 Avian Erythroblastic Leukemia Viral Oncogene Homolog 3; ErbB-3 R31; Tyrosine Kinase-Type Cell Surface Receptor HER3; MDA-BF-1; Human Epidermal Growth Factor Receptor 3; C-ErbB3; Receptor Tyrosine-Protein Kinase ErbB-3; ErbB3-S; Proto-Oncogene-Like Protein C-ErbB-3; ErbB-3; C-ErbB-3; FERLK; CDNA FLJ43038 Fis, Clone BRTHA3002955, Highly Similar To Receptor Tyrosine-Protein Kinase ErbB-3; VSCN1; Lethal Congenital Contracture Syndrome 2; Erb-B2 Receptor Tyrosine Kinase 3; P180-ErbB3
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FITC-labeled HER3 Protein, Human (HEK293, His-Avi)
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Cat. No.: HY-P701281
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: ERBB3; Receptor Protein-Tyrosine Kinase; Prev. LCCS2; P45-SErbB3; HER3; P85-SErbB3; V-Erb-B2 Avian Erythroblastic Leukemia Viral Oncogene Homolog 3; ErbB-3 R31; Tyrosine Kinase-Type Cell Surface Receptor HER3; MDA-BF-1; Human Epidermal Growth Factor Recep
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HER3 Protein, Rat (HEK293, His)
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Cat. No.: HY-P74891
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: ERBB3; Receptor Protein-Tyrosine Kinase; Prev. LCCS2; P45-SErbB3; HER3; P85-SErbB3; V-Erb-B2 Avian Erythroblastic Leukemia Viral Oncogene Homolog 3; ErbB-3 R31; Tyrosine Kinase-Type Cell Surface Receptor HER3; MDA-BF-1; Human Epidermal Growth Factor Recep
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HER3 Protein, Mouse (HEK293, His)
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Cat. No.: HY-P70857
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: ERBB3; Receptor Protein-Tyrosine Kinase; Prev. LCCS2; P45-SErbB3; HER3; P85-SErbB3; V-Erb-B2 Avian Erythroblastic Leukemia Viral Oncogene Homolog 3; ErbB-3 R31; Tyrosine Kinase-Type Cell Surface Receptor HER3; MDA-BF-1; Human Epidermal Growth Factor Receptor 3; C-ErbB3; Receptor Tyrosine-Protein Kinase ErbB-3; ErbB3-S; Proto-Oncogene-Like Protein C-ErbB-3; ErbB-3; C-ErbB-3; FERLK; CDNA FLJ43038 Fis, Clone BRTHA3002955, Highly Similar To Receptor Tyrosine-Protein Kinase ErbB-3; VSCN1; Lethal Congenital Contracture Syndrome 2; Erb-B2 Receptor Tyrosine Kinase 3; P180-ErbB3
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HER3 Protein, Rhesus Macaque (HEK293, Fc)
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Cat. No.: HY-P76968
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: ERBB3; Receptor Protein-Tyrosine Kinase; Prev. LCCS2; P45-SErbB3; HER3; P85-SErbB3; V-Erb-B2 Avian Erythroblastic Leukemia Viral Oncogene Homolog 3; ErbB-3 R31; Tyrosine Kinase-Type Cell Surface Receptor HER3; MDA-BF-1; Human Epidermal Growth Factor Recep
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HER3 Protein, Human (HEK293, His, solution)
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Cat. No.: HY-P72625A
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: ERBB3; Receptor Protein-Tyrosine Kinase; Prev. LCCS2; P45-SErbB3; HER3; P85-SErbB3; V-Erb-B2 Avian Erythroblastic Leukemia Viral Oncogene Homolog 3; ErbB-3 R31; Tyrosine Kinase-Type Cell Surface Receptor HER3; MDA-BF-1; Human Epidermal Growth Factor Recep
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HER3 Protein, Human (sf9, His-GST)
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Cat. No.: HY-P74893
Purity: ≥ 75%, as determined by reducing SDS-PAGE.
Synonyms: ERBB3; Receptor Protein-Tyrosine Kinase; Prev. LCCS2; P45-SErbB3; HER3; P85-SErbB3; V-Erb-B2 Avian Erythroblastic Leukemia Viral Oncogene Homolog 3; ErbB-3 R31; Tyrosine Kinase-Type Cell Surface Receptor HER3; MDA-BF-1; Human Epidermal Growth Factor Recep
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HER3 Protein, Human (Biotinylated, HEK293, His)
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Cat. No.: HY-P77554
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: ERBB3; Receptor Protein-Tyrosine Kinase; Prev. LCCS2; P45-SErbB3; HER3; P85-SErbB3; V-Erb-B2 Avian Erythroblastic Leukemia Viral Oncogene Homolog 3; ErbB-3 R31; Tyrosine Kinase-Type Cell Surface Receptor HER3; MDA-BF-1; Human Epidermal Growth Factor Recep
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HER3 Protein, Rat (HEK293, Fc)
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Cat. No.: HY-P74892
Purity: ≥ 80%, as determined by reducing SDS-PAGE.
Synonyms: ERBB3; Receptor Protein-Tyrosine Kinase; Prev. LCCS2; P45-SErbB3; HER3; P85-SErbB3; V-Erb-B2 Avian Erythroblastic Leukemia Viral Oncogene Homolog 3; ErbB-3 R31; Tyrosine Kinase-Type Cell Surface Receptor HER3; MDA-BF-1; Human Epidermal Growth Factor Recep
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HER3 Protein, Rhesus Macaque (HEK293)
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Cat. No.: HY-P76967
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: ERBB3; Receptor Protein-Tyrosine Kinase; Prev. LCCS2; P45-SErbB3; HER3; P85-SErbB3; V-Erb-B2 Avian Erythroblastic Leukemia Viral Oncogene Homolog 3; ErbB-3 R31; Tyrosine Kinase-Type Cell Surface Receptor HER3; MDA-BF-1; Human Epidermal Growth Factor Recep
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HER3 Protein, Rhesus Macaque (HEK293, His)
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Cat. No.: HY-P76969
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: ERBB3; Receptor Protein-Tyrosine Kinase; Prev. LCCS2; P45-SErbB3; HER3; P85-SErbB3; V-Erb-B2 Avian Erythroblastic Leukemia Viral Oncogene Homolog 3; ErbB-3 R31; Tyrosine Kinase-Type Cell Surface Receptor HER3; MDA-BF-1; Human Epidermal Growth Factor Recep
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Recombinant Protein Expression Service
- Codon Optimization
- Gene Synthesis
- Construction of Expression Vector
- Strain Screening
- Protein Expression
- Purification & QC
- Protein Delivery
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Capetin (28-54), human
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- Formula: Human
- Molecular Weight: Sf9 insect cells
The EpCAM/TROP1 protein serves as an important homogeneous interacting molecule that promotes direct contact between intestinal epithelial cells (IEC) and intraepithelial lymphocytes (IEL) in the mucosal epithelium. This feature helps establish an immune barrier against mucosal infections. EpCAM/TROP1 Protein, Human (His-SUMO) is the recombinant human-derived EpCAM/TROP1 protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag.
