1. Signaling Pathways
  2. PROTAC
  3. Ligand for E3 Ligase

Ligand for E3 Ligase

The PROTAC molecule consists of a ligand, which binds an E3 ubiquitin ligase, connected by a linker to another ligand that binds the target protein.

The association between a protein and an E3 ligase, as induced by a PROTAC molecule, will lead to the transfer of ubiquitin and degradation of the targeted protein.

Ligand for E3 Ligase Isoform Specific Products:

  • von Hippel-Lindau (VHL)

  • Cereblon

Ligand for E3 Ligase Related Products (33):

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-A0003
    Lenalidomide 191732-72-6 99.98%
    Lenalidomide interacts with E3 ligase cereblon, links casein kinase 1A1 (CKIα) to the human E3 ligase cereblon, and induces CKIa degradation.
    Lenalidomide
  • HY-10984
    Pomalidomide 19171-19-8 99.86%
    Pomalidomide is the third-generation immunomodulatory agent, functions through interacting with the E3 ligase cereblon and induces degradation of essential Ikaros transcription factors.
    Pomalidomide
  • HY-101291
    Iberdomide 1323403-33-3 98.90%
    Iberdomide (CC-220) is a cereblon (CRBN) modulator with an IC50 of 60 nM.
    Iberdomide
  • HY-42424
    E3 ligase Ligand 1 1948273-03-7 98.19%
    E3 ligase Ligand 1 is a Ligand for E3 Ligase extracted from patent WO/2017/030814A1 compound example 202, used in PROTAC technology.
    E3 ligase Ligand 1
  • HY-14658
    Thalidomide 50-35-1 99.91%
    Thalidomide is initially promoted as a sedative, inhibits ereblon (CRBN), a part of the cullin-4 E3 ubiquitin ligase complex CUL4-RBX1-DDB1, with a Kd of ∼250 nM, and has immunomodulatory, anti-inflammatory and anti-angiogenic cancer properties.
    Thalidomide
  • HY-115446A
    E3 ligase Ligand-Linker Conjugates 32 hydrochloride 98.24%
    E3 ligase Ligand-Linker Conjugates 32 hydrochloride is a Ligand with linker of BET for E3 Ligase used in PROTAC, with IC50 values of 0.98 nM and 13.7 nM in RS4;11 and MOLM-13 cells, respectively.
    E3 ligase Ligand-Linker Conjugates 32 hydrochloride
  • HY-111663
    VL285 1448188-57-5 98.38%
    VL285 is a potent VHL ligand.
    VL285
  • HY-128846
    E3 ligase Ligand 17 1957235-66-3
    E3 ligase Ligand 17 is a ligand for E3 ubiquitin ligase. E3 ligase Ligand 17 can be connected to the ligand for protein by a linker to form PROTACs or SNIPERs. PROTACs are inducers of ubiquitination-mediated degradation of cancer-promoting proteins.
    E3 ligase Ligand 17
  • HY-101763A
    Protein degrader 1 hydrochloride 1448189-80-7 99.05%
    Protein degrader 1 hydrochloride is a small molecule ligand for VHL, an E3 ligase which has been targeted in numerous PROTACs.
    Protein degrader 1 hydrochloride
  • HY-100947
    VH-298 2097381-85-4 99.32%
    VH-298 is a highly potent inhibitor of the VHL:HIF-α interaction with a Kd value of 80 to 90 nM, used in PROTAC technology.
    VH-298
  • HY-103597
    E3 ligase Ligand 3 1061605-21-7 99.39%
    E3 ligase Ligand 3 is a ligand of E3 ligase, used in PROTAC technology.
    E3 ligase Ligand 3
  • HY-A0003B
    Lenalidomide hemihydrate 847871-99-2 99.82%
    Lenalidomide interacts with E3 ligase cereblon, links casein kinase 1A1 (CKIα) to the human E3 ligase cereblon, and induces CKIa degradation.
    Lenalidomide hemihydrate
  • HY-101488
    CC-885 1010100-07-8 99.78%
    CC-885 is a cereblon (CRBN) modulator with potent anti-tumour activity.
    CC-885
  • HY-103596
    E3 ligase Ligand 2 5054-59-1 99.60%
    E3 ligase Ligand 2 is a ligand for E3 ligase used in PROTAC technology.
    E3 ligase Ligand 2
  • HY-42424A
    E3 ligase Ligand 1 dihydrochloride 98.19%
    E3 ligase Ligand 1 dihydrochloride is a von Hippel-Landau (VHL) E3 ligase-binding moiety based on PROTAC technology.
    E3 ligase Ligand 1 dihydrochloride
  • HY-41547
    E3 ligase Ligand 4 835616-60-9 98.77%
    E3 ligase Ligand 4 is a ligand of E3 ligase, used in PROTAC technology.
    E3 ligase Ligand 4
  • HY-114406
    TD-106 2250288-69-6 99.17%
    TD-106 is a cereblon (CRBN) modulator, which can be used for targeted protein degradation. BRD4 PROTACs with TD-106 induce BRD4 degradation.
    TD-106
  • HY-128846A
    E3 ligase Ligand 17 hydrochloride 2305369-00-8
    E3 ligase Ligand 17 hydrochloride is a ligand for E3 ubiquitin ligase. E3 ligase Ligand 17 hydrochloride can be connected to the ligand for protein by a linker to form PROTACs or SNIPERs. PROTACs are inducers of ubiquitination-mediated degradation of cancer-promoting proteins.
    E3 ligase Ligand 17 hydrochloride
  • HY-112078
    E3 ligase Ligand 1A 1948273-02-6
    E3 ligase Ligand 1A is a ligand of E3 ligase, used in PROTAC technology; E3 ligase Ligand 1A can be used in the research of cancer.
    E3 ligase Ligand 1A
  • HY-117937
    BC-1215 1507370-20-8
    BC-1215 is an inhibitor of F-box protein 3 (FBXO3, a ubiquitin E3 ligase component; IC50=0.9 μg/mL for IL-1β release). BC-1215 decreases Fbxo3-Fbxl2 interaction and prevents SCFFbxo3 catalyzed Fbxl2 ubiquitination. BC-1215 inhibits the Fbxo3-TRAF activation pathway by destabilizing TRAF1–TRAF6. BC-1215, interacts with ApaG to profoundly inhibit secretion of a broad spectrum of TH1 panel cytokines from human PBMC.
    BC-1215
Isoform Specific Products

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