1. PROTAC
  2. Ligand for E3 Ligase
  3. Protein degrader 1 hydrochloride

Protein degrader 1 hydrochloride 

Cat. No.: HY-101763A Purity: 99.05%
Handling Instructions

Protein degrader 1 hydrochloride is a small molecule ligand for VHL, an E3 ligase which has been targeted in numerous PROTACs.

For research use only. We do not sell to patients.

Protein degrader 1 hydrochloride Chemical Structure

Protein degrader 1 hydrochloride Chemical Structure

CAS No. : 1448189-80-7

Size Price Stock Quantity
100 mg USD 300 In-stock
Estimated Time of Arrival: December 31
500 mg USD 650 In-stock
Estimated Time of Arrival: December 31
1 g USD 1000 In-stock
Estimated Time of Arrival: December 31
5 g USD 2000 In-stock
Estimated Time of Arrival: December 31
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Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of Protein degrader 1 hydrochloride:

Top Publications Citing Use of Products
  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Protein degrader 1 hydrochloride is a small molecule ligand for VHL, an E3 ligase which has been targeted in numerous PROTACs.

IC50 & Target

E3 ligase VHL[1]

In Vitro

Synthesis of HaloPROTACs contains Protein degrader 1 (Degradation Inducing Moiety A). Protein degrader 1 (Degradation Inducing Moiety A) is capable of inducing the degradation of GFP-HaloTag7 in cell-based assays. HaloPROTACs containing Protein degrader 1 (Degradation Inducing Moiety A) lead to nearly 70% degradation of GFP-HaloTag7, when sufficiently long linkers are used[1].

Molecular Weight

467.02

Formula

C₂₂H₃₁ClN₄O₃S

CAS No.

1448189-80-7

SMILES

O=C([[email protected]](C[[email protected]@H](O)C1)N1C([[email protected]@H](N)C(C)(C)C)=O)NCC2=CC=C(C(SC=N3)=C3C)C=C2.Cl

Shipping

Room temperature in continental US; may vary elsewhere

Storage

4°C, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)

Solvent & Solubility
In Vitro: 

DMSO : 150 mg/mL (321.19 mM; Need ultrasonic)

H2O : 50 mg/mL (107.06 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.1412 mL 10.7062 mL 21.4124 mL
5 mM 0.4282 mL 2.1412 mL 4.2825 mL
10 mM 0.2141 mL 1.0706 mL 2.1412 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (5.35 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (5.35 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (5.35 mM); Clear solution

*All of the co-solvents are provided by MCE.
References

Purity: 99.05%

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This equation is commonly abbreviated as: C1V1 = C2V2

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Product Name:
Protein degrader 1 hydrochloride
Cat. No.:
HY-101763A
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