2. PROTAC
  3. Ligands for E3 Ligase
  4. (S,R,S)-AHPC hydrochloride

(S,R,S)-AHPC hydrochloride  (Synonyms: VH032-NH2 hydrochloride; VHL ligand 1 hydrochloride)

Cat. No.: HY-101763A Purity: 99.54%
COA Handling Instructions

(S,R,S)-AHPC (VH032-NH2) hydrochloride is the VH032-based VHL ligand used in the recruitment of the von Hippel-Lindau (VHL) protein. (S,R,S)-AHPC hydrochloride can be connected to the ligand for protein (e.g., BCR-ABL1) by a linker to form PROTACs (e.g., GMB-475). GMB-475 induces the degradation of BCR-ABL1 with an IC50 of 1.11 μM in Ba/F3 cells.

For research use only. We do not sell to patients.

(S,R,S)-AHPC hydrochloride Chemical Structure

(S,R,S)-AHPC hydrochloride Chemical Structure

CAS No. : 1448189-80-7

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Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of (S,R,S)-AHPC hydrochloride:

Top Publications Citing Use of Products

1 Publications Citing Use of MCE (S,R,S)-AHPC hydrochloride

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von Hippel-Lindau (VHL) MDM2 Cereblon IAP

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Description

(S,R,S)-AHPC (VH032-NH2) hydrochloride is the VH032-based VHL ligand used in the recruitment of the von Hippel-Lindau (VHL) protein. (S,R,S)-AHPC hydrochloride can be connected to the ligand for protein (e.g., BCR-ABL1) by a linker to form PROTACs (e.g., GMB-475). GMB-475 induces the degradation of BCR-ABL1 with an IC50 of 1.11 μM in Ba/F3 cells[1].

IC50 & Target

VHL

 

Molecular Weight

467.02

Appearance

Solid

Formula

C22H31ClN4O3S
CAS No.
SMILES

O=C([[email protected]](C[[email protected]@H](O)C1)N1C([[email protected]@H](N)C(C)(C)C)=O)NCC2=CC=C(C(SC=N3)=C3C)C=C2.Cl
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)
Solvent & Solubility
In Vitro: 

DMSO : 125 mg/mL (267.65 mM; Need ultrasonic)

H2O : 100 mg/mL (214.12 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.1412 mL 10.7062 mL 21.4124 mL
5 mM 0.4282 mL 2.1412 mL 4.2825 mL
10 mM 0.2141 mL 1.0706 mL 2.1412 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  PBS

    Solubility: 100 mg/mL (214.12 mM); Clear solution; Need ultrasonic

  • 2.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.08 mg/mL (4.45 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.08 mg/mL (4.45 mM); Clear solution

  • 4.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.08 mg/mL (4.45 mM); Clear solution

*All of the co-solvents are available by MCE.
Purity & Documentation

Purity: 99.54%

COA (251 KB) HNMR (273 KB) LCMS (99 KB)

Handling Instructions (2659 KB)
References
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Keywords:

(S,R,S)-AHPC1448189-80-7VH032-NH2VHL ligand 1VHL ligand1VHL ligand-1Ligands for E3 LigaseE3 ligase-recruiting MoietyInhibitorinhibitorinhibit

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