1. PROTAC
  2. Ligand for E3 Ligase
  3. (S,R,S)-AHPC

(S,R,S)-AHPC (Synonyms: MDK7526; VH032-NH2; VHL ligand 1)

Cat. No.: HY-125845
Handling Instructions

(S,R,S)-AHPC (MDK7526) is the VH032-based VHL ligand used in the recruitment of the von Hippel-Lindau (VHL) protein. (S,R,S)-AHPC (MDK7526) can be connected to the ligand for protein (e.g., BCR-ABL1) by a linker to form PROTACs (e.g., GMB-475). GMB-475 induces the degradation of BCR-ABL1 with an IC50 of 1.11 μM in Ba/F3 cells.

For research use only. We do not sell to patients.

(S,R,S)-AHPC Chemical Structure

(S,R,S)-AHPC Chemical Structure

CAS No. : 1448297-52-6

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Description

(S,R,S)-AHPC (MDK7526) is the VH032-based VHL ligand used in the recruitment of the von Hippel-Lindau (VHL) protein. (S,R,S)-AHPC (MDK7526) can be connected to the ligand for protein (e.g., BCR-ABL1) by a linker to form PROTACs (e.g., GMB-475). GMB-475 induces the degradation of BCR-ABL1 with an IC50 of 1.11 μM in Ba/F3 cells[1].

IC50 & Target[1]

VHL

 

Molecular Weight

430.56

Formula

C₂₂H₃₀N₄O₃S

CAS No.

1448297-52-6

SMILES

O=C([[email protected]](C[[email protected]@H](O)C1)N1C([[email protected]@H](N)C(C)(C)C)=O)NCC2=CC=C(C(SC=N3)=C3C)C=C2

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Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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(S,R,S)-AHPC
Cat. No.:
HY-125845
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