1. PROTAC
  2. Ligand for E3 Ligase
  3. E3 ligase Ligand 18

E3 ligase Ligand 18 

Cat. No.: HY-125845
Handling Instructions

E3 ligase Ligand 18 is a ligand for E3 ubiquitin ligase. E3 ligase Ligand 18 can be connected to the ligand for protein (e.g., BCR-ABL1) by a linker to form PROTACs (e.g., GMB-475). GMB-475 induces the degradation of BCR-ABL1 with an IC50 of 1.11 μM in Ba/F3 cells.

For research use only. We do not sell to patients.

E3 ligase Ligand 18 Chemical Structure

E3 ligase Ligand 18 Chemical Structure

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Description

E3 ligase Ligand 18 is a ligand for E3 ubiquitin ligase. E3 ligase Ligand 18 can be connected to the ligand for protein (e.g., BCR-ABL1) by a linker to form PROTACs (e.g., GMB-475). GMB-475 induces the degradation of BCR-ABL1 with an IC50 of 1.11 μM in Ba/F3 cells[1].

IC50 & Target[1]

VHL

 

Molecular Weight

430.56

Formula

C₂₂H₃₀N₄O₃S

SMILES

N[[email protected]](C(C)(C)C)C(N1[[email protected]](C(NCC2=CC=C(C3=C(C)N=CS3)C=C2)=O)C[[email protected]@H](O)C1)=O

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Room temperature in continental US; may vary elsewhere

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Product Name:
E3 ligase Ligand 18
Cat. No.:
HY-125845
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