1. PROTAC
  2. Ligand for E3 Ligase
  3. Thalidomide-O-COOH

Thalidomide-O-COOH (Synonyms: Cereblon ligand 3; E3 ligase Ligand 3)

Cat. No.: HY-103597 Purity: 99.39%
Handling Instructions

Thalidomide-O-COOH (Cereblon ligand 3) is the Thalidomide-based Cereblon ligand used in the recruitment of CRBN protein. Thalidomide-O-COOH (Cereblon ligand 3) can be connected to the ligand for protein by a linker to form PROTACs.

For research use only. We do not sell to patients.

Thalidomide-O-COOH Chemical Structure

Thalidomide-O-COOH Chemical Structure

CAS No. : 1061605-21-7

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Based on 1 publication(s) in Google Scholar

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Description

Thalidomide-O-COOH (Cereblon ligand 3) is the Thalidomide-based Cereblon ligand used in the recruitment of CRBN protein. Thalidomide-O-COOH (Cereblon ligand 3) can be connected to the ligand for protein by a linker to form PROTACs[1].

IC50 & Target

Cereblon

 

Molecular Weight

332.26

Formula

C₁₅H₁₂N₂O₇

CAS No.

1061605-21-7

SMILES

O=C(N(C(CCC1=O)C(N1)=O)C2=O)C(C2=CC=C3)=C3OCC(O)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)

Solvent & Solubility
In Vitro: 

DMSO : ≥ 42 mg/mL (126.41 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.0097 mL 15.0485 mL 30.0969 mL
5 mM 0.6019 mL 3.0097 mL 6.0194 mL
10 mM 0.3010 mL 1.5048 mL 3.0097 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (7.52 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (7.52 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (7.52 mM); Clear solution

*All of the co-solvents are provided by MCE.

Purity: 99.39%

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Keywords:

Thalidomide-O-COOHCereblon ligand 3E3 ligase Ligand 3Cereblon ligand3Cereblon ligand-3Ligand for E3 LigaseE3 ligase-recruiting MoietyInhibitorinhibitorinhibit

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Thalidomide-O-COOH
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