Signaling Pathway

Integrin

Integrin

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Integrin Inhibitors & Modulators (19)

Product Name Catalog No. Brief Description
Arg-Gly-Asp-Ser

HY-12290

Arg-Gly-Asp-Ser(RGDS peptide) is an integrin binding sequence that inhibits integrin receptor function; decreases systemic inflammation via inhibition of collagen-triggered activation of leukocytes and attenuates expression of inflammatory cytokines, iNOS and MMP-9.

ATN-161

HY-13535

ATN-161 (Ac-PHSCN-NH2) is a five -amino-acid peptide derived from the synergy region of fibronectin; a beta integrin antagonist with antitumor activity.

ATN-161 trifluoroacetate salt

HY-13535A

ATN-161 trifluoroacetate salt (Ac-PHSCN-NH2 trifluoroacetate salt) is a five -amino-acid peptide derived from the synergy region of fibronectin; a beta integrin antagonist with antitumor activity.

Cilengitide

HY-16141

Cilengitide (EMD 121974; NSC 707544) is a potent integrin inhibitor for αvβ3 and αvβ5 integrin with IC50 of 4.1 nM and 79 nM, respectively; ~10-fold selectivity against gpIIbIIIa.

Cucurbitacin B

HY-N0416

Cucurbitacin B belongs to a class of highly oxidized tetracyclic triterpenoids; could repress cancer cell progression.

CWHM-12

HY-18644

CWHM-12 a novel small molecule inhibitor of αV integrins with IC50s of 1.8/0.8/1.5/0.2 nM for αvβ1/αvβ3/αvβ8; less potency on αvβ5(IC50=61 nM) and on inhibition on αIIbβ3/α2β1/α10β1.

Cyclo(-RGDfK)

HY-P0023

Cyclo(-RGDfK) is a potent and selective inhibitor of the αvβ3 integrin.

Cyclo(RADfK)

HY-P0031

Cyclo(RADfK) is a selective α(v)β(3) integrin ligand that has been extensively used for research, therapy, and diagnosis of neoangiogenesis.

E7820

HY-14571

E7820 is an angiogenesis inhibitorby suppressing integrin a2, a cell adhesion molecule expressed on endothelial cells.

Firategrast

HY-14951

Firategrast is an orally bioavailable alpha4 beta1/alpha4 beta7 integrin antagonist designed to reduce trafficking of lymphocytes into the central nervous system (CNS).

ILK-IN-1

HY-18676

ILK-IN-1 is a novel ILK inhibitor with IC50 of 0.6 μM.

ILK-IN-2

HY-18676B

ILK-IN-2 is a ILK inhibitor.

Integrin Antagonist 1 hydrochloride

HY-19767A

Integrin Antagonist 1 hydrochloride is a small molecule integrin αvβ6 antagonist, extracted from patent WO/2014154725A1, example 1.

Integrin Antagonists 27

HY-18668

Integrin Antagonists 27 is a small molecule integrin αvβ3 antagonist with binding affinity of 18 nM, as s novel anticancer agent.

Lifitegrast

HY-19344

Lifitegrast is an integrin lymphocyte function-associated antigen-1 (LFA-1) antagonist; inhibits Jurkat T cell attachment to ICAM-1 with an IC50 of 2.98 nM.

Tirofiban

HY-17369B

Tirofiban(L700462;MK383) is a potent non-peptide, glycoprotein IIb/IIIa (integrins alphaIIbbetaIII) antagonist
Target: integrin IIb/IIIa
Tirofiban hydrochloride monohydrate blocks platelet aggregation and thrombus formation.

Tirofiban hydrochloride monohydrate

HY-17369

Tirofiban hydrochloride monohydrate is a potent non-peptide, glycoprotein IIb/IIIa (integrins alphaIIbbetaIII) antagonist.

TR-14035

HY-15770

TR-14035 is a a dual alpha4beta7(IC50=7 nM)/alpha4beta1 (IC50=87 nM) integrin antagonist .

Zaurategrast

HY-70073

Zaurategrast(CDP-323) is an oral α4-integrin inhibitor.