1. Cytoskeleton
  2. Integrin

Cyclo(-RGDfK) 

Cat. No.: HY-P0023 Purity: >98.0%
Handling Instructions

Cyclo(-RGDfK) is a potent and selective inhibitor of the αvβ3 integrin, with a IC50 of 0.94 nM. Sequence: Cyclo(Arg-Gly-Asp-Phe-Lys).

For research use only. We do not sell to patients.

Custom Peptide Synthesis

Cyclo(-RGDfK) Chemical Structure

Cyclo(-RGDfK) Chemical Structure

CAS No. : 161552-03-0

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 185 In-stock
Estimated Time of Arrival: December 31
5 mg USD 139 In-stock
Estimated Time of Arrival: December 31
10 mg USD 216 In-stock
Estimated Time of Arrival: December 31
50 mg USD 660 In-stock
Estimated Time of Arrival: December 31
100 mg USD 900 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

* Please select Quantity before adding items.

  • Biological Activity

  • Technical Information

  • Purity & Documentation

  • References

Description

Cyclo(-RGDfK) is a potent and selective inhibitor of the αvβ3 integrin, with a IC50 of 0.94 nM. Sequence: Cyclo(Arg-Gly-Asp-Phe-Lys).

IC50 & Target

IC50: 0.94 nM (αvβ3 integrin)[1].

In Vitro

Cyclo(-RGDfK) is a potent and selective inhibitor of the αvβ3 integrin, with a IC50 of 0.94 nM[1]. [(66)Ga]DOTA-E-[c(RGDfK)]2 can be prepared with high radiochemical purity (>97%), specific activity (36-67GBq/μM), in vitro stability, and moderate protein binding. MicroPET imaging up to 24 post-injection showed contrasting tumors reflecting αvβ3-targeted tracer accumulation[2].

Solvent & Solubility
In Vitro: 

DMSO : ≥ 150 mg/mL (248.48 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.6565 mL 8.2827 mL 16.5653 mL
5 mM 0.3313 mL 1.6565 mL 3.3131 mL
10 mM 0.1657 mL 0.8283 mL 1.6565 mL
*Please refer to the solubility information to select the appropriate solvent.
References
Molecular Weight

603.67

Formula

C₂₇H₄₁N₉O₇

CAS No.

161552-03-0

Storage
Powder -80°C 2 years
  -20°C 1 year
In solvent -80°C 6 months
  -20°C 1 month
Shipping

Room temperature in continental US; may vary elsewhere

Purity: >98.0%

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The dilution calculator equation

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This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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Product Name:
Cyclo(-RGDfK)
Cat. No.:
HY-P0023
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Cyclo(-RGDfK)

Cat. No.: HY-P0023