1. Cytoskeleton
  2. Integrin
  3. Cyclo(-RGDfK)

Cyclo(-RGDfK) 

Cat. No.: HY-P0023 Purity: >98.0%
Handling Instructions

Cyclo(-RGDfK) is a potent and selective inhibitor of the αvβ3 integrin, with an IC50 of 0.94 nM.

For research use only. We do not sell to patients.

Cyclo(-RGDfK) Chemical Structure

Cyclo(-RGDfK) Chemical Structure

CAS No. : 161552-03-0

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 185 In-stock
Estimated Time of Arrival: December 31
5 mg USD 139 In-stock
Estimated Time of Arrival: December 31
10 mg USD 216 In-stock
Estimated Time of Arrival: December 31
50 mg USD 660 In-stock
Estimated Time of Arrival: December 31
100 mg USD 900 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

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Customer Review

Based on 1 publication(s) in Google Scholar

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Description

Cyclo(-RGDfK) is a potent and selective inhibitor of the αvβ3 integrin, with an IC50 of 0.94 nM.

IC50 & Target

IC50: 0.94 nM (αvβ3 integrin)[1].

In Vitro

Cyclo(-RGDfK) is a potent and selective inhibitor of the αvβ3 integrin, with a IC50 of 0.94 nM[1]. [(66)Ga]DOTA-E-[c(RGDfK)]2 can be prepared with high radiochemical purity (>97%), specific activity (36-67GBq/μM), in vitro stability, and moderate protein binding. MicroPET imaging up to 24 post-injection showed contrasting tumors reflecting αvβ3-targeted tracer accumulation[2].

Molecular Weight

603.67

Formula

C₂₇H₄₁N₉O₇

CAS No.

161552-03-0

Sequence

Cyclo(Arg-Gly-Asp-Phe-Lys)

Sequence Shortening

Cyclo(RGDFK)

SMILES

O=C([[email protected]](CCCCN)NC([[email protected]@H](CC1=CC=CC=C1)NC([[email protected]](CC(O)=O)NC(CN2)=O)=O)=O)N[[email protected]@H](CCCNC(N)=N)C2=O

Shipping

Room temperature in continental US; may vary elsewhere

Storage
Powder -80°C 2 years
  -20°C 1 year
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 125 mg/mL (207.07 mM; Need ultrasonic)

H2O : 50 mg/mL (82.83 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.6565 mL 8.2827 mL 16.5653 mL
5 mM 0.3313 mL 1.6565 mL 3.3131 mL
10 mM 0.1657 mL 0.8283 mL 1.6565 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.08 mg/mL (3.45 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.08 mg/mL (3.45 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.08 mg/mL (3.45 mM); Clear solution

*All of the co-solvents are provided by MCE.
References

Purity: >98.0%

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Product Name:
Cyclo(-RGDfK)
Cat. No.:
HY-P0023
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