1. Cytoskeleton
  2. Integrin

Cyclo(-RGDfK) (Synonyms: Cyclo(RGDfK) peptide; Cyclic RGDfK peptide)

Cat. No.: HY-P0023 Purity: >98.0%
Handling Instructions

Cyclo(-RGDfK) is a potent and selective inhibitor of the αvβ3 integrin.

For research use only. We do not sell to patients.
Cyclo(-RGDfK) Chemical Structure

Cyclo(-RGDfK) Chemical Structure

CAS No. : 161552-03-0

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 185 In-stock
5 mg USD 139 In-stock
10 mg USD 216 In-stock
50 mg USD 660 In-stock
100 mg USD 900 In-stock
200 mg   Get quote  
500 mg   Get quote  

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  • Biological Activity

  • Protocol

  • Technical Information

  • Purity & Documentation

  • References

Description

Cyclo(-RGDfK) is a potent and selective inhibitor of the αvβ3 integrin. IC50 value: Target: αvβ3 integrin inhibitor in vitro: NOPO-c(RGDfK) and its Ga(III) and Cu(II) complexes showed high affinity to αvβ3 integrin (IC50 = 0.94 ± 0.06, 1.02 ± 0.09, and 0.51 ± 0.06 nM, respectively) [1]. [(66)Ga]DOTA-E-[c(RGDfK)]2 can be prepared with high radiochemical purity (>97%), specific activity (36-67GBq/μmol), in vitro stability, and moderate protein binding. MicroPET imaging up to 24 post-injection showed contrasting tumors reflecting αvβ3-targeted tracer accumulation [2].

References
Molecular Weight

603.67

Formula

C₂₇H₄₁N₉O₇

CAS No.

161552-03-0

SMILES

O=C([[email protected]](CCCCN)NC([[email protected]@H](CC1=CC=CC=C1)NC([[email protected]](CC(O)=O)NC(CN2)=O)=O)=O)N[[email protected]@H](CCCNC(N)=N)C2=O

Storage
Powder -80°C 2 years
  -20°C 1 year
In solvent -80°C 6 months
  -20°C 1 month
Shipping

Room temperature in continental US; may vary elsewhere

Solvent & Solubility

DMSO: ≥ 150 mg/mL

* "<1 mg/mL" means slightly soluble or insoluble. "≥" means soluble, but saturation unknown.

Purity: >98.0%

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Product Name:
Cyclo(-RGDfK)
Cat. No.:
HY-P0023
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