1. Cytoskeleton
  2. Integrin
  3. Cyclo(-RGDfK)

Cyclo(-RGDfK) 

Cat. No.: HY-P0023 Purity: >98.0%
Handling Instructions

Cyclo(-RGDfK) is a potent and selective inhibitor of the αvβ3 integrin, with an IC50 of 0.94 nM. Cyclo(-RGDfK) TFA potently targets tumor microvasculature and cancer cells through the specific binding to the αvβ3 integrin on the cell surface.

For research use only. We do not sell to patients.

Cyclo(-RGDfK) Chemical Structure

Cyclo(-RGDfK) Chemical Structure

CAS No. : 161552-03-0

Size Price Stock Quantity
10 mM * 1  mL in DMSO USD 185 In-stock
Estimated Time of Arrival: December 31
5 mg USD 139 In-stock
Estimated Time of Arrival: December 31
10 mg USD 216 In-stock
Estimated Time of Arrival: December 31
50 mg USD 660 In-stock
Estimated Time of Arrival: December 31
100 mg USD 900 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

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Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of Cyclo(-RGDfK):

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Description

Cyclo(-RGDfK) is a potent and selective inhibitor of the αvβ3 integrin, with an IC50 of 0.94 nM[1]. Cyclo(-RGDfK) TFA potently targets tumor microvasculature and cancer cells through the specific binding to the αvβ3 integrin on the cell surface[2].

IC50 & Target

IC50: 0.94 nM (αvβ3 integrin)[1].

In Vitro

Cyclo(-RGDfK) is a potent and selective inhibitor of the αvβ3 integrin, with a IC50 of 0.94 nM[1]. [66Ga]DOTA-E-[c(RGDfK)]2 can be prepared with high radiochemical purity (>97%), specific activity (36-67GBq/μM), in vitro stability, and moderate protein binding. MicroPET imaging up to 24 post-injection showed contrasting tumors reflecting αvβ3-targeted tracer accumulation[2].

Molecular Weight

603.67

Formula

C₂₇H₄₁N₉O₇

CAS No.

161552-03-0

Sequence

Cyclo(Arg-Gly-Asp-Phe-Lys)

Sequence Shortening

Cyclo(RGDFK)

SMILES

O=C([[email protected]](CCCCN)NC([[email protected]@H](CC1=CC=CC=C1)NC([[email protected]](CC(O)=O)NC(CN2)=O)=O)=O)N[[email protected]@H](CCCNC(N)=N)C2=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -80°C 2 years
  -20°C 1 year
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 125 mg/mL (207.07 mM; Need ultrasonic)

H2O : 50 mg/mL (82.83 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.6565 mL 8.2827 mL 16.5653 mL
5 mM 0.3313 mL 1.6565 mL 3.3131 mL
10 mM 0.1657 mL 0.8283 mL 1.6565 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.08 mg/mL (3.45 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.08 mg/mL (3.45 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.08 mg/mL (3.45 mM); Clear solution

*All of the co-solvents are provided by MCE.
References

Purity: >98.0%

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Keywords:

Cyclo(-RGDfK)IntegrinMicrovasculaturecancerαvβ3 integrintumoral cellligandInhibitorinhibitorinhibit

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Product Name:
Cyclo(-RGDfK)
Cat. No.:
HY-P0023
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