1. Cytoskeleton
  2. Integrin
  3. Cyclo(-RGDfK) TFA

Cyclo(-RGDfK) TFA 

Cat. No.: HY-P0023A Purity: 98.48%
Handling Instructions

Cyclo(-RGDfK) TFA is a potent and selective inhibitor of the αvβ3 integrin, with an IC50 of 0.94 nM. Cyclo(-RGDfK) TFA potently targets tumor microvasculature and cancer cells through the specific binding to the αvβ3 integrin on the cell surface.

For research use only. We do not sell to patients.

Cyclo(-RGDfK) TFA Chemical Structure

Cyclo(-RGDfK) TFA Chemical Structure

CAS No. : 500577-51-5

Size Price Stock Quantity
10 mM * 1  mL in DMSO USD 219 In-stock
Estimated Time of Arrival: December 31
5 mg USD 139 In-stock
Estimated Time of Arrival: December 31
10 mg USD 216 In-stock
Estimated Time of Arrival: December 31
50 mg USD 660 In-stock
Estimated Time of Arrival: December 31
100 mg   Get quote  
200 mg   Get quote  

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Based on 1 publication(s) in Google Scholar

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Description

Cyclo(-RGDfK) TFA is a potent and selective inhibitor of the αvβ3 integrin, with an IC50 of 0.94 nM[1]. Cyclo(-RGDfK) TFA potently targets tumor microvasculature and cancer cells through the specific binding to the αvβ3 integrin on the cell surface[3].

IC50 & Target

IC50: 0.94 nM (αvβ3 integrin)[1]

In Vitro

Cyclo(-RGDfK) is a potent and selective inhibitor of the αvβ3 integrin and exhibits a IC50 of 0.94 nM[1].
[66Ga]DOTA-E-[c(RGDfK)]2 can be prepared with high radiochemical purity (>97%), specific activity (36-67GBq/μM), in vitro stability, and moderate protein binding. MicroPET imaging up to 24 post-injection showed contrasting tumors reflecting αvβ3-targeted tracer accumulation[2].

Molecular Weight

717.69

Formula

C₂₉H₄₂F₃N₉O₉

CAS No.

500577-51-5

Sequence

Cyclo(Arg-Gly-Asp-Phe-Lys)

Sequence Shortening

Cyclo(RGDFK)

SMILES

O=C(O)C(F)(F)F.O=C([[email protected]](CCCCN)NC([[email protected]@H](CC1=CC=CC=C1)NC([[email protected]](CC(O)=O)NC(CN2)=O)=O)=O)N[[email protected]@H](CCCNC(N)=N)C2=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -80°C 2 years
  -20°C 1 year
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (139.34 mM; Need ultrasonic)

H2O : 33.33 mg/mL (46.44 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.3934 mL 6.9668 mL 13.9336 mL
5 mM 0.2787 mL 1.3934 mL 2.7867 mL
10 mM 0.1393 mL 0.6967 mL 1.3934 mL
*Please refer to the solubility information to select the appropriate solvent.
References
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Keywords:

Cyclo(-RGDfK)IntegrinMicrovasculaturecancerαvβ3 integrintumoral cellligandInhibitorinhibitorinhibit

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Cyclo(-RGDfK) TFA
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