1. Protein Tyrosine Kinase/RTK
  2. ALK

ALK

ALK (Anaplastic lymphoma kinase) is encoded by the ALK gene. ALK is a membrane associated tyrosine kinase receptor of the insulin receptor superfamily. The function of the full-length ALK receptor is poorly understood. It has a probable role in the central and peripheral nervous system development and maintenance. ALK is a dependence receptor, which may exert antagonist functions, proapoptotic or antiapoptotic, depending on the absence or presence of a ligand. Dependence receptors have a potential role in cancer and development. Ligands available for this demonstration were agonist anti-ALK antibodies. ALK is still an orphan receptor, given the high level of controversy about pleiotrophin and midkine.

ALK Related Products (32):

Cat. No. Product Name Effect Purity
  • HY-10431
    SB-431542 Inhibitor
    SB-431542 is a potent and selective inhibitor of ALK5 and ALK4 with IC50 values of 94 nM and 14 nM, respectivelly, and is also an inhibitor of TGF-β Receptor.
  • HY-50878
    Crizotinib Inhibitor
    Crizotinib is a potent inhibitor of c-Met and ALK with IC50 of 11 nM and 24 nM in cell-based assays, respectively.
  • HY-12215
    PF-06463922 Inhibitor
    PF-06463922 is a potent, dual ALK/ROS1 inhibitor, with Ki of < 0.02 nM, < 0.07 nM, and 0.7 nM for ROS1, ALK (WT), and ALK (L1196M), respectively.
  • HY-15656
    LDK378 Inhibitor
    LDK378 is a potent and more specific ALK inhibitor with IC50 of 0.2 nM.
  • HY-13011
    CH5424802 Inhibitor
    CH5424802 is a potent, selective, and orally available ALK inhibitor with IC50 of 1.9 nM, the dissociation constant (KD) value for ALK in an ATP-competitive manner is 2.4 nM using a competition-binding assay.
  • HY-16590
    Ensartinib Inhibitor
    Ensartinib is a potent inhibitor of ALK, which is used to treat non-small-cell lung cancer.
  • HY-12071
    LDN193189 Inhibitor
    LDN193189 is a selective BMP type I receptor kinases inhibitor, which inhibits transcriptional activity of the BMP type I receptors ALK2 and ALK3 (IC50=5 nM and 30 nM, respectively), with substantially weaker effects on activin and the TGF-β type I receptors ALK4, ALK5 and ALK7 (IC50≥500 nM).
  • HY-12071A
    LDN193189 Hydrochloride Inhibitor
    LDN193189 hydrochloride is a selective BMP type I receptor kinases inhibitor, which inhibits transcriptional activity of the BMP type I receptors ALK2 and ALK3 (IC50=5 nM and 30 nM, respectively), with substantially weaker effects on activin and the TGF-β type I receptors ALK4, ALK5 and ALK7 (IC50≥500 nM).
  • HY-13521
    SB-505124 Inhibitor
    SB-505124 is a selective inhibitor of TGFβR with IC50 of 129 nM and 47 nM for ALK4, ALK5, respectively, and it does not inhibits ALK1, 2, 3, or 6 but ALK7.
  • HY-10192
    NVP-TAE 684 Inhibitor
    NVP-TAE 684 is a highly potent and selective ALK inhibitor, which blocks the growth of ALCL-derived and ALK-dependent cell lines with IC50 values between 2 and 10 nM.
  • HY-15656A
    LDK378 dihydrochloride Inhibitor
    LDK378 2Hcl (Ceritinib) is potent inhibitor against ALK with IC50 of 0.2 nM, shows 40- and 35-fold selectivity against IGF-1R and InsR, respectively.
  • HY-50878A
    Crizotinib hydrochloride Inhibitor
    Crizotinib Hcl(PF-2341066) is a potent inhibitor of c-Met and ALK with IC50 of 11 nM and 24 nM, respectivley.
  • HY-12278
    K02288 Inhibitor
    K02288 is a novel small molecule inhibitor of ALK1/2/3/6 with IC50s of 1.8/1.1/34.4/6.3 nM; specific for ALK1,2,3,6 over ALK4,5; inhibitor of BMP signaling.
  • HY-12273
    DMH-1 Inhibitor
    DMH-1 is a potent and selective BMP inhibitor with IC50s of 27/107.9/<5 nM for ALK1/2/3 respectively; inactive on ALK5, BMPR2, AMPK and VEGFR2.
  • HY-12274
    ML347 Inhibitor
    ML347(DN193719) is a highly selective ALK1/ALK2 inhibitor with IC50s of 46/32 nM; shows >300-fold selectivity for ALK2 vs. ALK3.
  • HY-15897
    LDN-212854 Inhibitor
    LDN-212854 is a novel BMP inhibitor that exhibits substantially greater selectivity for BMP versus the TGF-β type I receptors; possesses a bias towards ALK2(IC50=1.3 nM) versus ALK1 and ALK3 compared to other inhibitors.
  • HY-13326
    ASP3026 Inhibitor
    ASP3026 is a novel and selective inhibitor for ALK with IC50 of 3.5 nM.
  • HY-13020
    GSK1838705A Inhibitor
    GSK1838705A is a potent small-molecule IGF-IR, the insulin receptor and anaplastic lymphoma kinase (ALK) inhibitor with IC50 of 2.0, 1.6 and 0.5 nM, respectively.
  • HY-15841
    CEP-37440 Inhibitor
    CEP-37440 is a novel potent and selective Dual FAK/ALK inhibitor with IC50 s of 2.3 nM (FAK) and 120 nM(ALK cellular IC50 in 75% human plasma).
  • HY-15358
    ALK inhibitor 2 Inhibitor
    ALK inhibitor 2 is a novel and selective inhibitor for the ALK kinase.