1. Signaling Pathways
  2. Metabolic Enzyme/Protease
  3. RAR/RXR

RAR/RXR

The nuclear retinoic acid receptors (RARs) are transcriptional transregulators, which control the expression of specific gene subsets subsequently to ligand binding and to strictly controlled phosphorylation processes. RARs consist of three subtypes, α (NR1B1), β (NR1B2) and γ (NR1B3), encoded by separate genes. RARs function as ligand-dependent transcriptional regulators, heterodimerized with retinoid X receptors (RXRs), which also consist of three types, α NR2B1, β (NR2B2) and γ (NR2B3). RARs play critical roles in a variety of biological processes, including development, reproduction, immunity, organogenesis and homeostasis, as assessed by vitamin A-deficiency (VAD), pharmacological and genetic studies conducted in the mouse.

Retinoid X receptor (RXR) belongs to a family of ligand-activated transcription factors that regulate many aspects of metazoan life. A class of nuclear receptors requires RXR as heterodimerization partner for their function.

RAR/RXR Related Products (32):

Cat. No. Product Name Effect Purity
  • HY-14649
    Retinoic acid Agonist 98.36%
    Retinoic acid is a metabolite of vitamin A that plays important roles in cell growth, differentiation, and organogenesis. Retinoic acid is a natural agonist of RAR nuclear receptors, with IC50s of 14 nM for RARα/β/γ. Retinoic acid bind to PPARβ/δ with Kd of 17 nM.
  • HY-14171
    Bexarotene Agonist 99.81%
    Bexarotene (LGD1069) is a selective retinoid X receptors (RXR) agonist for the treatment of cutaneous T-cell lymphoma.
  • HY-10475
    AM580 Agonist 99.41%
    AM580 is a selective RARα agonist with IC50 and EC50 of 8 nM and 0.36 nM, respectively.
  • HY-14652
    Tamibarotene Agonist 99.77%
    Tamibarotene is a retinoic acid receptor α/β (RARα/β) agonist, showing high selectivity over RARγ.
  • HY-15373
    Fenretinide Inhibitor 99.41%
    Fenretinide is a synthetic retinoid deriverative, binding to the retinoic acid receptors (RAR) at concentrations necessary to induce cell death.
  • HY-111843
    RAR ligand 1
    RAR ligand 1 is a retinoic acid ligand, which targets RAR. RAR ligand 1 binds to cIAP1 ligand Bestatin via a linker to form PROTACs.
  • HY-14799
    Palovarotene Agonist 99.16%
    Palovarotene is a nuclear retinoic acid receptor γ (RAR-γ) agonist.
  • HY-N0163
    Magnolol Agonist 99.72%
    Magnolol, a natural lignan isolated from the stem bark of Magnolia officinalis, is a dual agonist of both RXRα and PPARγ, with EC50 values of 10.4 µM and 17.7 µM, respectively.
  • HY-15127
    Isotretinoin Inhibitor
    Isotretinoin(13-cis-Retinoic acid) is a medication used for the treatment of severe acne.
  • HY-15682
    TTNPB Agonist 99.31%
    TTNPB is a highly potent RAR agonist. Competitive binding assays using human RARs yield IC50s of α=5.1 nM, β= 4.5 nM, and γ=9.3 nM, respectively.
  • HY-107500
    UVI 3003 Inhibitor >98.0%
    UVI 3003 is a highly selective antagonist of retinoid X receptor (RXR), and inhibits xenopus and human RXRα in Cos7 cells, with IC50s of 0.22 and 0.24 μM, respectively.
  • HY-U00449
    AGN 193109 Antagonist 98.50%
    AGN 193109 is a retinoid analog, and acts as a specific and highly effective antagonist of retinoic acid receptors (RARs), with Kds of 2 nM, 2 nM, and 3 nM for RARα, RARβ, and RARγ, respectively.
  • HY-B0091
    Adapalene Agonist >98.0%
    Adapalene(CD-271; Differin), a synthetic retinoid, is a retinoic acid receptor agonist (RAR).
  • HY-16681
    AGN 194310 Agonist 98.02%
    AGN 194310(VTP-194310) is a potent and selective pan-RARs agonist with Kd values of 3/2/5 nM for RARα/β/γ respectively.
  • HY-100532
    CD437 Agonist >98.0%
    CD437 is a selective Retinoic Acid Receptor γ (RARγ) agonist.
  • HY-101106
    AR7 Antagonist 98.77%
    AR7 is a retinoic acid receptor α (RARα) antagonist.
  • HY-10291
    Tarenflurbil Inhibitor 99.99%
    Tarenflurbil ((R)-Flurbiprofen) is the R-enantiomer of the racemate NSAID Flurbiprofen, Tarenflurbil ((R)-Flurbiprofen) inhibits the binding of [3H]9-cis-RA to RXRα LBD with IC50 of 75 μM.
  • HY-16684
    AGN 195183 Agonist 98.40%
    AGN 195183 is a potent and selective agonist of RARα(Kd=3 nM) with improved binding selectivity relative to AGN 193836; no activity on RARβ/γ.
  • HY-15388
    Tazarotene Agonist 98.68%
    Tazarotene (AGN 190168) is a selective retinoic acid receptor (RAR) agonist for the treatment of plaque psoriasis and acne vulgaris.
  • HY-B0107
    Acitretin Agonist 99.56%
    Acitretin(Ro 10-1670) is a second-generation, systemic retinoid that has been used in the treatment of psoriasis.
Isoform Specific Products

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