2. Recombinant Proteins
  3. CD Antigens
  4. Platelet CD Proteins

Platelet CD Proteins

Platelet CD Proteins

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The cluster of differentiation (CD) antigens is a protocol used for the identification and investigation of cell surface molecules present on leukocytes. Some CD proteins often act as cell-cell or cell-matrix adhesion molecules, cytokine receptors, ion pores, or nutrient transporters. CD proteins play a variety of roles in immune system function. Platelets are the smallest blood cells that are cytoplasmic fragments derived from their bone marrow precursor, the megakaryocyte. Quiescent platelets express a large number of surface proteins, including CD9, CD29, CD31, CD36, CD41, CD42a, CD42b, CD61 and GPVI2,3. Surface levels of some of these molecules (e.g., CD41 and CD61) are increased following platelet activation, while other proteins which are virtually absent from the surface of resting platelets, such as CD62P, CD63, CD107a and CD154, are translocated from intracellular stores to the plasma membrane following activation.

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