1. Recombinant Proteins
  2. Cytokines and Growth Factors
  3. PDGF & PDGFR
  4. PDGF

Platelet-derived growth factors (PDGFs) are potent mitogenic factors (mitogens) that regulate cell growth and division, in connective tissue and the developing nervous system. PDGFs are secreted from many cell types including platelets, endothelial, epithelial, glial and inflammatory cells. PDGFs target a broad spectrum of mesoderm-derived cells, like fibroblasts, pericytes, smooth muscle cells, glial cells or mesangial cells. Four PDGF genes (PDGFA, PDGFB, PDGFC and PDGFD) edit 5 biologically active PDGF proteins which consist of a homodimer (PDGF-AA, PDGF-BB, PDGF-CC, and PDGF-DD) or heterodimer (PDGF-AB) of two chains. PDGFs are characterized by a highly conserved eight-cysteine residues domain termed the PDGF/VEGF homology domain. There are two cognate transmembrane receptors, PDGFRα and PDGFRβ, two distinct class III receptor tyrosine kinases. PDGFRα binds PDGF-A, -B and -C, while PDGFRβ can only be activated by PDGF-B and -D. The receptors dimerize upon ligand binding and cross-phosphorylate intracellular tyrosine residues. These phosphorylated residues serve as binding sites for downstream signaling components and activate, among others, phospholipase C γ (PLCγ), phosphatidyl inositol 3-kinase (PI3K), and JAK-STAT signaling. Overall, PDGFs exert their cellular effects by inducing homo- or heterodimeric complexes of α- and β-tyrosine kinase receptors, resulting in cell growth, chemotaxis, actin reorganization, and prevention of apoptosis.

Cat. No. Product Name / Synonyms Species Source
  • HY-P73720
    PDGF-A Protein, Rat (P.pastoris, His)

    Platelet-derived growth factor subunit A; PDGF-1; PDGF-A; Rpa1

    Rat P.pastoris
  • HY-P7278
    PDGF-BB Protein, Rat

    rRtPDGF-BB; PDGF-2; Pdgfb

    Rat E. coli
    PDGF-BB Protein, Rat is a member of PDGF family, which promotes cell proliferation, survival and migration, through binding to the tyrosine kinase PDGF receptor.
  • HY-P7055
    PDGF-BB Protein, Human

    rHuPDGF-BB; PDGF-2; GDGF; ODGF; SIS; SSV

    Human E. coli
    PDGF-BB Protein, Human is the most active PDGF isoform, binds to PDGF receptor, promotes diverse cell types proliferation and osteogenesis, and further stimulates bone formation in fracture or defect.
  • HY-P7087
    PDGF-BB Protein, Mouse

    rMuPDGF-BB; PDGF-2; GDGF; ODGF; SIS; SSV

    Mouse E. coli
    PDGF-BB Protein, Mouse is an active PDGF isoform, used in cell culture applications.
  • HY-P7277
    PDGF-AA Protein, Mouse

    rMuPDGF-AA; PDGF-1; Pdgfa

    Mouse E. coli
    PDGF-AA Protein, Mouse is a member of PDGF family, binds to FDGFR, and may has the potential to enhance wound healing.
  • HY-P7280
    PDGF-D Protein, Human (CHO)

    rHuPDGF-DD; Platelet-derived growth factor D; SCDGFB

    Human CHO
    PDGF-DD Protein, Human (CHO) is a member of the PDGF family, specifically binds to and activates its cognate receptor PDGFR-β, and participates in regulating cancer proliferation, transformation, and invasion through activating multiple downstream oncogenic pathways, resulting in tumor development and progression.
  • HY-P70699
    PDGF-BB Protein, Mouse (His)

    PDGFBB; PDGF-BB

    Mouse E. coli
  • HY-P70825
    PDGF-AA Protein, Human (His)

    PDGFAA; PDGF-AA

    Human E. coli
    PDGF-AA Protein, Human (His) is a member of PDGF family, binds to FDGFR, and may has the potential to enhance wound healing.
  • HY-P70598
    PDGF-AA Protein, Human

    PDGFAA; PDGF-AA

    Human E. coli
  • HY-P7279
    PDGF-CC Protein, Human (HEK293)

    rHuPDGF-CC; PDGF-C; SCDGF

    Human HEK293
    PDGF-CC Protein, Human (HEK293) is a member of the PDGF family, binds to PDGFR-α and PDGFR-β and acts as potent angiogenic factor.
  • HY-P7055A
    PDGF-BB Protein, Human (P.pastoris)

    rHuPDGF-BB; PDGF-2; GDGF; ODGF; SIS; SSV

    Human P. pastoris
    PDGF-BB Protein, Human (P.pastoris) is the most active PDGF isoform, binds to PDGF receptor, promotes diverse cell types proliferation and osteogenesis, and further stimulates bone formation in fracture or defect.
  • HY-P7055G
    GMP PDGF-BB Protein, Human

    PDGFBB; PDGF-BB

    Human E. coli
  • HY-P71615
    PDGF-D Protein, Mouse (His-SUMO)

    Pdgfd; Scdgfb; Platelet-derived growth factor D; PDGF-D; Spinal cord-derived growth factor B; SCDGF-B

    Mouse E. coli
  • HY-P73351
    PDGF-BB Protein, Human (P.pastoris, His)

    Platelet-derived growth factor subunit B; PDGF subunit B; PDGF2; PDGFB; SIS

    Human P. pastoris
  • HY-P73352
    PDGF-BB Protein, Mouse (P.pastoris, His)

    Platelet-derived growth factor subunit B; PDGF subunit B; PDGF2; PDGFB; SIS

    Mouse P. pastoris
  • HY-P73353
    PDGF-CC Protein, Human (HEK293, Fc)

    PDGF-C; Platelet derived growth factor C; VEGF-E; SCDGF

    Human HEK293
  • HY-P73354
    PDGF-CC Protein, Mouse (HEK293, Fc)

    PDGF-C; Platelet derived growth factor C; VEGF-E; SCDGF

    Mouse HEK293
  • HY-P73719
    PDGF-CC Protein, Mouse (P.pastoris, His)

    PDGF-C; Platelet derived growth factor C; VEGF-E; SCDGF

    Mouse P. pastoris
  • HY-P74640
    PDGF-CC Protein, Cynomolgus (HEK293, hFc)

    PDGF-C; Platelet derived growth factor C; VEGF-E; SCDGF

    Cynomolgus HEK293
  • HY-P74641
    PDGF-B Protein, Rhesus Macaque (P.pastoris, His)

    Platelet-derived growth factor subunit B; PDGF-2; PDGFB

    Rhesus Macaque P. pastoris
Cat. No. Product Name Effect Purity