PDGF-C
PDGF-C is a later-discovered member of the platelet-derived growth factor family, encoded by PDGFC and secreted as a latent homodimer, PDGF-CC. Unlike PDGF-A and PDGF-B, each PDGF-C chain carries an N-terminal CUB domain that must be proteolytically removed, in vivo by tissue plasminogen activator and plasmin, before the mature dimer can activate PDGFR-alpha and PDGFR-alpha/beta. PDGF-C drives fibroblast proliferation and is upregulated in liver and kidney fibrosis; PDGFC-null mice show cleft palate, abnormal kidney vasculature, and defective cerebral vessels. Recombinant PDGF-C protein, supplied as latent or activated forms, is used to study protease-dependent growth-factor activation and fibrotic signaling.
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PDGF-C Recombinant Proteins (5)
Recombinant Protein Expression Service
- Codon Optimization
- Gene Synthesis
- Construction of Expression Vector
- Strain Screening
- Protein Expression
- Purification & QC
- Protein Delivery
- Formula: Human
- Molecular Weight: Sf9 insect cells
The EpCAM/TROP1 protein serves as an important homogeneous interacting molecule that promotes direct contact between intestinal epithelial cells (IEC) and intraepithelial lymphocytes (IEL) in the mucosal epithelium. This feature helps establish an immune barrier against mucosal infections. EpCAM/TROP1 Protein, Human (His-SUMO) is the recombinant human-derived EpCAM/TROP1 protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag.
