Signaling Pathway

Mixed Lineage Kinase

Mixed Lineage Kinase

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Mixed Lineage Kinase Inhibitors & Modulators (2)

Product Name Catalog No. Brief Description


Necrosulfonamide is a pharmacological inhibitor of MLKL with IC50 values of 124 nM in human HT-29.



URMC-099 is an orally bioavailable, brain penetrant inhibitor of Mixed Lineage Kinase 3(MLK3) with IC50 of 14 nM; inhibits LPS-induced TNFα release in microglial cells, HIV-1 Tat-induced release of cytokines in human monocytes, and up-regulation of phospho-JNK in Tat-injected brains of mice.