3032600-90-8
3032600-90-8
Chemical Structure
PROTAC MLKL Degrader-1
- CAS No.: 3032600-90-8
- Formula:C46H55F2N9O9S
- Molecular Weight:948.05
InChIKey: XDPRKJSOJYMCMZ-UHFFFAOYSA-N
SMILES: O=C(C1=C(NN=C1C2=CC=C(C=C2)NS(C(F)F)(=O)=O)NC3=CC=CC(OCCCCCCCC(N4CCC5(CCN(CC5)C(C6=CC=C(C(N7CCC(NC7=O)=O)=C6)OC)=O)CC4)=O)=C3)N
Biological Activity: PROTAC MLKL Degrader-1 is a selective MLKL PROTAC degrader with a DC50 of 2.4 μM. PROTAC MLKL Degrader-1 blocks necroptosis without modulating the phosphorylation of RIPK1 or RIPK3, and exhibits a linear correlation between MLKL levels and necroptotic cell death[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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PROTAC MLKL Degrader-1 | 99.76% | PROTAC MLKL Degrader-1 is a selective MLKL PROTAC degrader with a DC50 of 2.4 μM. PROTAC MLKL Degrader-1 blocks necroptosis without modulating the phosphorylation of RIPK1 or RIPK3, and exhibits a linear correlation between MLKL levels and necroptotic cell death. | ||||||||||||||||||||
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References
Keywords
