RIPK1
RIPK1 is a death-domain kinase that sits at the crossroads of TNF receptor-1 signaling, deciding between cell survival, apoptosis and necroptosis. TNF binding recruits RIPK1 into complex I, where K63-linked ubiquitination supports NF-kappaB activation and survival; loss of ubiquitin editing by CYLD or of complex-I integrity redirects RIPK1 toward RIPK3-driven necroptosis or, together with FADD and caspase-8, toward apoptosis. RIPK1 kinase activity is dispensable for NF-kappaB signaling but required for its death-inducing functions, which is why ATP-competitive inhibitors such as GSK2982772 are being tested in psoriasis, rheumatoid arthritis and ulcerative colitis. Human RIPK1 loss-of-function causes combined immunodeficiency with enterocolitis.
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RIPK1 Recombinant Proteins (6)
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Recombinant Protein Expression Service
- Codon Optimization
- Gene Synthesis
- Construction of Expression Vector
- Strain Screening
- Protein Expression
- Purification & QC
- Protein Delivery
- Formel: Human
- Molecular Weight: Sf9 insect cells
The EpCAM/TROP1 protein serves as an important homogeneous interacting molecule that promotes direct contact between intestinal epithelial cells (IEC) and intraepithelial lymphocytes (IEL) in the mucosal epithelium. This feature helps establish an immune barrier against mucosal infections. EpCAM/TROP1 Protein, Human (His-SUMO) is the recombinant human-derived EpCAM/TROP1 protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag.
