1. Apoptosis
  2. Caspase

Caspase

Caspase is a family of cysteine proteases that play essential roles in apoptosis (programmed cell death), necrosis, and inflammation. There are two types of apoptotic caspases: initiator (apical) caspases and effector (executioner) caspases. Initiator caspases (e.g., CASP2, CASP8, CASP9, and CASP10) cleave inactive pro-forms of effector caspases, thereby activating them. Effector caspases (e.g., CASP3, CASP6, CASP7) in turn cleave other protein substrates within the cell, to trigger the apoptotic process. The initiation of this cascade reaction is regulated by caspase inhibitors. CASP4 and CASP5, which are overexpressed in some cases of vitiligo and associated autoimmune diseases caused by NALP1 variants, are not currently classified as initiator or effector in MeSH, because they are inflammatory enzymes that, in concert with CASP1, are involved in T-cell maturation.

Caspase Related Products (14):

Cat. No. Product Name Effect Purity
  • HY-16658
    Z-VAD-FMK Inhibitor >98.0%
    Z-VAD-FMK is a cell-permeable, pan-caspase inhibitor.
  • HY-13251
    Silvestrol Activator 99.28%
    Silvestrol, a potential anticancer rocaglate derivative from Aglaia foveolata, induces apoptosis in LNCaP cells through the mitochondrial/apoptosome pathway without activation of executioner caspase-3 or -7; 5'myc-UTR-LUC inhibtior (IC50= 0.8 nM).
  • HY-13205
    VX-765 Inhibitor 98.94%
    VX-765 is an orally active IL-converting enzyme/caspase-1 inhibitor, inhibits IL-1β release with similar potency in PBMCs from FCAS (IC50=0.99±0.29 μM) and control (IC50=1.1±0.61 μM) subjects.
  • HY-12466
    Z-DEVD-FMK Inhibitor >98.00%
    Z-DEVD-FMK is a specific caspase-3 inhibitor with IC50 of 18 μM.
  • HY-13010
    Laquinimod Inhibitor 99.84%
    Laquinimod (ABR-215062) is a potent immunomodulator.
  • HY-12305
    Q-VD-OPh Inhibitor 99.26%
    Q-VD-OPha is a pan-caspase inhibitor with potent antiapoptotic properties; inhibits caspase 1, 3, 8 and 9 with IC50 values of 50, 25, 100, and 430 nM, respectively.
  • HY-N2027
    Taurochenodeoxycholic acid Activator 99.80%
    Taurochenodeoxycholic acid is one of the main bioactive substances of animals' bile acid.
  • HY-N0100
    Naringenin 98.05%
    Naringenin is the predominant flavanone in grapefruit; displays strong anti-inflammatory and antioxidant activities.
  • HY-18938
    Selonsertib Inhibitor >98.0%
    GS-4997 is a highly selective and potent once-daily oral ASK1 inhibitor that competes with ATP in the ASK1 catalytic kinase domain.
  • HY-13229
    BOC-D-FMK Inhibitor
    Boc-D-FMK is a cell-permeable, irreversible and broad spectrum caspase inhibitor; inhibits apoptosis stimulated by TNF-α with an IC50 of 39 µM.
  • HY-13523
    PAC-1 Activator 98.70%
    PAC-1 is an activator of procaspase-3 induces apoptosis in cancer cells with EC50 of 2.08 μM.
  • HY-19566
    NQDI-1 Inhibitor 98.04%
    NQDI-1 inhibits apoptosis signal-regulating kinase 1 (ASK1) with a Ki of 500 nM.
  • HY-100844
    ASK1-IN-1 Inhibitor 99.33%
    ASK1-IN-1 is an apoptosis signal regulating kinase 1 (ASK1) inhibitor extracted from patent WO2016025474A1, Compound 4.
  • HY-100894
    Biotin-VAD-FMK Inhibitor
    Biotin-VAD-FMK is a cell permeable, irreversible biotin-labeled caspase inhibitor, used to identify active caspases in cell lysates.