Z-IETD-FMK
Based on 69 publication(s) in Google Scholar
Z-IETD-FMK (Z-IE(OMe)TD(OMe)-FMK) is a selective and cell permeable caspase-8 inhibitor. Z-IETD-FMK is also a granzyme B inhibitor.
For research use only. We do not sell to patients.
- Purity: 98.0%
- CAS No.: 210344-98-2
- Formula: C30H43FN4O11
- Molecular Weight:654.68
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Storage:
Sealed storage, away from moisture.
Powder -80°C, 2 years , -20°C, 1 year* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Protocol
- Purity & Documentation
- References
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) Z-IETD-FMK
More- Signal Transduct Target Ther. 2025 Dec 15;10(1):406. [Abstract]
- Cell. 2025 May 29;188(11):3013-3029.e19. [Abstract]
- Cell. 2024 Dec 26;187(26):7533-7550.e23. [Abstract]
- Nat Immunol. 2025 Mar;26(3):416-428. [Abstract]
- Nat Biomed Eng. 2023 Mar;7(3):281-297. [Abstract]
- Immunity. 2025 Jul 16:S1074-7613(25)00287-0. [Abstract]
- Cell Mol Immunol. 2023 Oct;20(10):1203-1215. [Abstract]
- Mol Cell. 2025 Jul 3;85(13):2581-2596.e6. [Abstract]
- Nat Commun. 2025 Aug 7;16(1):7309. [Abstract]
- Cell Death Differ. 2024 Sep;31(9):1140-1156. [Abstract]
- Sci Adv. 2023 Oct 6;9(40):eadi6586. [Abstract]
- Sci Adv. 2022 Nov 11;8(45):eabn9912. [Abstract]
- MedComm. 2024 Jan 11;5(1):e457. [Abstract]
- J Immunother Cancer. 2024 Sep 5;12(9):e008663. [Abstract]
- Pharmacol Res. 2020 Feb;152:104616. [Abstract]
- Cancer Lett. 2021 Nov 1:520:143-159. [Abstract]
- Cell Death Dis. 2025 Jun 17;16(1):452. [Abstract]
- Cell Death Dis. 2019 Feb 11;10(2):118. [Abstract]
- Int J Biol Macromol. 2024 Aug 22:135015. [Abstract]
- Acta Pharmacol Sin. 2021 Jan;42(1):68-76. [Abstract]
- Apoptosis. 2026 Feb 2;31(2):60. [Abstract]
- Apoptosis. 2019 Aug;24(7-8):673-685. [Abstract]
- Cell Death Discov. 2024 Mar 8;10(1):122. [Abstract]
- Cell Rep. 2026 Apr 20;45(4):117140. [Abstract]
- J Pineal Res. 2024 Jan 31.
- Cell Mol Life Sci. 2025 Nov 19;82(1):408. [Abstract]
- Cell Mol Life Sci. 2024 Aug 19;81(1):355. [Abstract]
- J Agric Food Chem. 2019 Jul 3;67(26):7378-7389. [Abstract]
- Chem Biol Interact. 2021 Dec 1:350:109704. [Abstract]
- PLoS Pathog. 2024 Jul 22;20(7):e1012408. [Abstract]
- Int J Mol Sci. 2022 Nov 25;23(23):14730. [Abstract]
- Front Pharmacol. 2020 Dec 10:11:534171. [Abstract]
- Int Immunopharmacol. 2025 Jun 7:161:115025. [Abstract]
- Int J Cancer. 2019 Sep 1;145(5):1371-1381. [Abstract]
- Virol Sin. 2024 May 30:S1995-820X(24)00078-6. [Abstract]
- Fish Shellfish Immunol. 2021 Jun:113:24-34. [Abstract]
- Oncol Rep. 2021 Mar;45(3):1261-1272. [Abstract]
- Viruses. 2025 Jul 22;17(8):1025. [Abstract]
- Viruses. 2024 Oct 30;16(11):1695. [Abstract]
- Food Chem Toxicol. 2019 Oct:132:110655. [Abstract]
- Food Chem Toxicol. 2018 Oct:120:143-154. [Abstract]
- J Immunol. 2025 Jun 1;214(6):1219-1235. [Abstract]
- J Cancer. 2024 Sep 30;15(18):6038-6051. [Abstract]
- mSphere. 2024 May 17:e0023624. [Abstract]
- Mol Immunol. 2023 Jan:153:160-169. [Abstract]
- Mol Immunol. 2018 Jul:99:19-29. [Abstract]
- Discov Oncol. 2025 Jul 12;16(1):1320. [Abstract]
- Infect Immun. 2025 Aug 12;93(8):e0015825. [Abstract]
- Front Genet. 2022 Mar 3;12:831420. [Abstract]
- Vet Microbiol. 2020 Jun;245:108709. [Abstract]
- Vet Microbiol. 2020 Jan;240:108510. [Abstract]
- PLoS One. 2021 Mar 26;16(3):e0248175. [Abstract]
- Virology. 2025 Feb 1:604:110443. [Abstract]
- Amino Acids. 2021 Jun;53(6):869-880. [Abstract]
- Med Sci Monit. 2018 Dec 3:24:8722-8733. [Abstract]
- Biochem Cell Biol. 2018 Oct;96(5):548-555. [Abstract]
- Curr Eye Res. 2025 Feb;50(2):203-212. [Abstract]
- Res Vet Sci. 2022 Mar:143:124-133. [Abstract]
- Lab Med. 2023 Mar 7;54(2):130-141. [Abstract]
- SSRN. 2025 Oct 15.
- bioRxiv. 2025 March 20.
- University of Zaragoza. 2025.
- Preprints. 2024 Aug 14.
- Research Square Preprint. 2024 Apr 25.
- SSRN. 2023 Nov 8.
- Pharmacological Research-Modern Chinese Medicine. 29 August 2022, 100157.
- Research Square Print. 2022 May.
- Research Square Preprint. 2020 Aug.
- Masaryk University. 2020 Jul.
Customer Validation & Images
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Cell Imaging/Staining
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2D/3D Cell Culture and Differentiation
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WB
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WB
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All Caspase Isoforms
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Biological Activity
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Caspase-8 |
T-cellZ-IETD-FMK causes full inhibition only of the proapoptotic effect of TNFα with an IC50 of 0.46 μM[1]. Z-IETD-FMK and Z-VAD-FMK at non-toxic doses are found to be immunosuppressive and inhibit human T cell proliferation induced by mitogens and IL-2. They are shown to block NF-κB in activated primary T cells, but have little inhibitory effect on the secretion of IL-2 and IFN-γ during T cell activation[2]. Z-IETD-FMK inhibits the cleavage of caspase-8 and only partially inhibits the cleavage of caspase-3 and PARP. Z-IETD-FMK can prevent the execution of apoptosis in retinal cells exposed to different apoptotic stimuli[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 210344-98-2
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Appearance Solid
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Molecular Weight 654.68
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Formula C30H43FN4O11
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Color White to light yellow
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Synonyms
Z-IE(OMe)TD(OMe)-FMK
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Sequence
Z-Ile-Glu-Thr-Asp-FMK
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Sequence Shortening
ZIETDFMK
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Sealed storage, away from moisture
Powder -80°C 2 years -20°C 1 year * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Publications (69)
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Journal Impact Factor
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Most Recent
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Signal Transduct Target Ther
Selective depletion of tumor-associated SAMHD1 enhances chemotherapeutic efficacy and antitumor immune responses. [Abstract]2025 Dec 15;10(1):406. PMID: 41392286 -
Cell
2025 May 29;188(11):3013-3029.e19. PMID: 40252640 -
Cell
Type III interferons induce pyroptosis in gut epithelial cells and impair mucosal repair. [Abstract]2024 Dec 26;187(26):7533-7550.e23. PMID: 39500322
Z-IETD-FMK purchased from MedChemExpress. Usage Cited in: Cell. 2024 Dec 26;187(26):7533-7550.e23. [Abstract]
Organoids were treated with Z-IETD-FMK (Z-IETD, 40 μM, 16 h) during rIFN-λ treatment.
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Nat Immunol
2025 Mar;26(3):416-428. PMID: 39891018 -
Nat Biomed Eng
Activatable near-infrared probes for the detection of specific populations of tumour-infiltrating leukocytes in vivo and in urine. [Abstract]2023 Mar;7(3):281-297. PMID: 36941352 -
Immunity
Gasdermin C cleavage by Cathepsin S modulates Rab7 vesicles in intestinal epithelial cells to amplify anti-helminth immunity. [Abstract]2025 Jul 16:S1074-7613(25)00287-0. PMID: 40701157 -
Cell Mol Immunol
2023 Oct;20(10):1203-1215. PMID: 37591930
Z-IETD-FMK purchased from MedChemExpress. Usage Cited in: Cell Mol Immunol. 2023 Oct;20(10):1203-1215. [Abstract]
THP-1 monocytes were pretreated for 0.5 h with DMSO or Z-IETD-FMK (25 μM) and stimulated for 6 h with heat-killed gram-negative bacteria at twice the number of cells. Immunoblots showing caspase-8, caspase-1 and IL-1β in total cell lysate are representative of one of two experimental repeats.
Z-IETD-FMK purchased from MedChemExpress. Usage Cited in: Cell Mol Immunol. 2023 Oct;20(10):1203-1215. [Abstract]
PBMCs were pretreated for 0.5 h with DMSO or Z-IETD-FMK (25 μM) and stimulated for 16 h with heat-killed gram-negative bacteria at twice the number of monocytes.
Z-IETD-FMK purchased from MedChemExpress. Usage Cited in: Cell Mol Immunol. 2023 Oct;20(10):1203-1215. [Abstract]
THP-1 monocytes were pretreated for 0.5 h with DMSO or Z-IETD-FMK (25 μM) and stimulated at a specific time point with heat-killed E. coli XL10 at twice the number of cells. Immunoblots showing P-TAK1, caspase-8 and caspase-1 in total cell lysate are representative of one of two experimental repeats.
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Mol Cell
2025 Jul 3;85(13):2581-2596.e6. PMID: 40555234 -
Nat Commun
RIPK1 kinase drove brain microvascular endothelial cells death and blood-brain barrier disruption in neonatal Escherichia coli meningitis. [Abstract]2025 Aug 7;16(1):7309. PMID: 40774959 -
Cell Death Differ
PD-L2 drives resistance to EGFR-TKIs: dynamic changes of the tumor immune environment and targeted therapy. [Abstract]2024 Sep;31(9):1140-1156. PMID: 38816578 -
Sci Adv
Human cytomegalovirus UL36 inhibits IRF3-dependent immune signaling to counterbalance its immunoenhancement as apoptotic inhibitor. [Abstract]2023 Oct 6;9(40):eadi6586. PMID: 37792941 -
Sci Adv
Caspase-8 inactivation drives autophagy-dependent inflammasome activation in myeloid cells. [Abstract]2022 Nov 11;8(45):eabn9912. PMID: 36367942 -
MedComm
Silibinin, a potential fasting mimetic, inhibits hepatocellular carcinoma by triggering extrinsic apoptosis. [Abstract]2024 Jan 11;5(1):e457. PMID: 38222315 -
J Immunother Cancer
Immune isolation-enabled nanoencapsulation of donor T cells: a promising strategy for mitigating GVHD and treating AML in preclinical models. [Abstract]2024 Sep 5;12(9):e008663. PMID: 39242117 -
Pharmacol Res
Icariside II inhibits tumorigenesis via inhibiting AKT/Cyclin E/ CDK 2 pathway and activating mitochondria-dependent pathway. [Abstract]2020 Feb;152:104616. PMID: 31883767 -
Cancer Lett
Photodynamic therapy induces human esophageal carcinoma cell pyroptosis by targeting the PKM2/caspase-8/caspase-3/GSDME axis. [Abstract]2021 Nov 1:520:143-159. PMID: 34256094 -
Cell Death Dis
Repurposing MDM2 inhibitor RG7388 for TP53-mutant NSCLC: a p53-independent pyroptotic mechanism via ROS/p-p38/NOXA/caspase-3/GSDME axis. [Abstract]2025 Jun 17;16(1):452. PMID: 40523886
Z-IETD-FMK purchased from MedChemExpress. Usage Cited in: Cell Death Dis. 2025 Jun 17;16(1):452. [Abstract]
Representative phase-contrast images of pyroptotic cell death induced by RG7388 in H23 cells pretreated with or without pan-caspase inhibitor Z-VAD-FMK (zVAD, 50 μM), caspase-8 inhibitor Z-IETD-FMK (Cas8i, 50 μM) or caspase-3 inhibitor Z-DEVD-FMK (Cas3i, 25 μM) as indicated for 6 hours
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Cell Death Dis
Targeting KPNB1 overcomes TRAIL resistance by regulating DR5, Mcl-1 and FLIP in glioblastoma cells. [Abstract]2019 Feb 11;10(2):118. PMID: 30742128 -
Int J Biol Macromol
IL-18 signaling is regulated by caspase 6/8 and IL-18BP in turbot (Scophthalmus maximus). [Abstract]2024 Aug 22:135015. PMID: 39181350 -
Acta Pharmacol Sin
Gasdermin E-derived caspase-3 inhibitors effectively protect mice from acute hepatic failure. [Abstract]2021 Jan;42(1):68-76. PMID: 32457417 -
Apoptosis
CD95 ligand drives abdominal aortic aneurysm progression through Caspase-8-mediated GSDMD-dependent endothelial pyroptosis: modulation by SRC kinase. [Abstract]2026 Feb 2;31(2):60. PMID: 41622361 -
Apoptosis
CNOT3 contributes to cisplatin resistance in lung cancer through inhibiting RIPK3 expression. [Abstract]2019 Aug;24(7-8):673-685. PMID: 31177396 -
Cell Death Discov
2024 Mar 8;10(1):122. PMID: 38458999 -
Cell Rep
2026 Apr 20;45(4):117140. PMID: 42054206 -
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Cell Mol Life Sci
2025 Nov 19;82(1):408. PMID: 41258568 -
Cell Mol Life Sci
Influenza A virus infection activates caspase-8 to enhance innate antiviral immunity by cleaving CYLD and blocking TAK1 and RIG-I deubiquitination. [Abstract]2024 Aug 19;81(1):355. PMID: 39158695 -
J Agric Food Chem
Mechanism of Juglone-Induced Cell Cycle Arrest and Apoptosis in Ishikawa Human Endometrial Cancer Cells. [Abstract]2019 Jul 3;67(26):7378-7389. PMID: 31184118 -
Chem Biol Interact
Dihydroartemisinin mediating PKM2-caspase-8/3-GSDME axis for pyroptosis in esophageal squamous cell carcinoma. [Abstract]2021 Dec 1:350:109704. PMID: 34655567 -
PLoS Pathog
2024 Jul 22;20(7):e1012408. PMID: 39038037 -
Int J Mol Sci
2022 Nov 25;23(23):14730. PMID: 36499060 -
Front Pharmacol
Quercetin Induces Apoptosis via Downregulation of Vascular Endothelial Growth Factor/Akt Signaling Pathway in Acute Myeloid Leukemia Cells. [Abstract]2020 Dec 10:11:534171. PMID: 33362534 -
Int Immunopharmacol
Caspase-8-driven NLRP3 inflammasome activation exacerbates bronchopulmonary dysplasia by increasing the apoptosis and pyroptosis crosstalk of alveolar epithelial cells. [Abstract]2025 Jun 7:161:115025. PMID: 40483833 -
Int J Cancer
2019 Sep 1;145(5):1371-1381. PMID: 30807646 -
Virol Sin
Pseudorabies virus VHS protein abrogates interferon responses by blocking NF-κB and IRF3 nuclear translocation. [Abstract]2024 May 30:S1995-820X(24)00078-6. PMID: 38823782 -
Fish Shellfish Immunol
Induction of apoptosis in SSN-1cells by Snakehead Fish Vesiculovirus (SHVV) via Matrix protein dependent intrinsic pathway. [Abstract]2021 Jun:113:24-34. PMID: 33757800 -
Oncol Rep
DMAPT‑D6 induces death‑receptor‑mediated apoptosis to inhibit glioblastoma cell oncogenesis via induction of DNA damage through accumulation of intracellular ROS. [Abstract]2021 Mar;45(3):1261-1272. PMID: 33469671 -
Viruses
DNAJ Homolog Subfamily C Member 11 Stabilizes SARS-CoV-2 NSP3 to Promote Double-Membrane Vesicle Formation. [Abstract]2025 Jul 22;17(8):1025. PMID: 40872740 -
Viruses
Apoptotic Caspases Suppress Expression of Endogenous Retroviruses in HPV31+ Cells That Are Associated with Activation of an Innate Immune Response. [Abstract]2024 Oct 30;16(11):1695. PMID: 39599810 -
Food Chem Toxicol
Methyl protodioscin from Polygonatum sibiricum inhibits cervical cancer through cell cycle arrest and apoptosis induction. [Abstract]2019 Oct:132:110655. PMID: 31271762 -
Food Chem Toxicol
2018 Oct:120:143-154. PMID: 29990575
Z-IETD-FMK purchased from MedChemExpress. Usage Cited in: Food Chem Toxicol. 2018 Oct:120:143-154. [Abstract]
Z-IETD-FMK remarkably decreases the dioscin-induced up regulation of Caspase-3
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J Immunol
2025 Jun 1;214(6):1219-1235. PMID: 40073091 -
J Cancer
Jolkinolide B Inhibits Gastric Cancer Growth by Targeting the PANoptosis Molecular Switch Caspase-8. [Abstract]2024 Sep 30;15(18):6038-6051. PMID: 39440048 -
mSphere
Mammalian orthoreovirus capsid protein σ3 antagonizes RLR-mediated antiviral responses by degrading MAVS. [Abstract]2024 May 17:e0023624. PMID: 38757961 -
Mol Immunol
Synergism of TNF-α and IFN-β triggers human airway epithelial cells death by apoptosis and pyroptosis. [Abstract]2023 Jan:153:160-169. PMID: 36508750 -
Mol Immunol
Sub-lethal ultraviolet B irradiation and Poly I:C treatment synergistically induced apoptosis of HaCaT cells through NF-κB pathway. [Abstract]2018 Jul:99:19-29. PMID: 29674236 -
Discov Oncol
RAD51 modulates in nasopharyngeal carcinoma cells by regulating Caspase-8-mediated pyroptosis. [Abstract]2025 Jul 12;16(1):1320. PMID: 40650821 -
Infect Immun
Rickettsia heilongjiangensis suppresses RIPK1 kinase-mediated host cell death during the infection. [Abstract]2025 Aug 12;93(8):e0015825. PMID: 40607949 -
Front Genet
Exosome-Derived LncRNA TCONS_00072128 Mediated Osteogenic Differentiation and Inflammation by Caspase 8 Regulation. [Abstract]2022 Mar 3;12:831420. PMID: 35308164 -
Vet Microbiol
Bta-miR-2890 up-regulates JAK-STAT pathway to inhibit BoHV-1 replication by targeting viral gene UL41. [Abstract]2020 Jun;245:108709. PMID: 32456827 -
Vet Microbiol
Cell apoptosis regulated by interaction between viral gene alpha 3 and host heterogeneous nuclear ribonucleoprotein K facilitates bovine ephemeral fever virus replication. [Abstract]2020 Jan;240:108510. PMID: 31902512 -
PLoS One
Induction of interferon-β and interferon signaling by TRAIL and Smac mimetics via caspase-8 in breast cancer cells. [Abstract]2021 Mar 26;16(3):e0248175. PMID: 33770100 -
Virology
Porcine epidemic diarrhea coronavirus infection activates caspase-8 to enhance innate immunity by blocking CYLD-mediated deubiquitination of RIG-I. [Abstract]2025 Feb 1:604:110443. PMID: 39908775 -
Amino Acids
Apoptosis-mediated anticancer activity in prostate cancer cells of a chestnut honey (Castanea sativa L.) quinoline-pyrrolidine gamma-lactam alkaloid. [Abstract]2021 Jun;53(6):869-880. PMID: 33945018 -
Med Sci Monit
Hypoxia-Inducible Factor 1-α (HIF-1α) Induces Apoptosis of Human Uterosacral Ligament Fibroblasts Through the Death Receptor and Mitochondrial Pathways. [Abstract]2018 Dec 3:24:8722-8733. PMID: 30504760 -
Biochem Cell Biol
MiR-21 regulates the apoptosis of keloid fibroblasts by caspase-8 and the mitochondria-mediated apoptotic signaling pathway via targeting FasL. [Abstract]2018 Oct;96(5):548-555. PMID: 29527928 -
Curr Eye Res
TLR4/TRIF/Caspase-8/Caspase-1 Pathway in Choroidal Endothelial Cells Promotes Choroidal Neovascularization. [Abstract]2025 Feb;50(2):203-212. PMID: 39392113 -
Res Vet Sci
Aconitine induces cell apoptosis via mitochondria and death receptor signaling pathways in hippocampus cell line. [Abstract]2022 Mar:143:124-133. PMID: 35026629 -
Lab Med
Combination of Circulating Cell-Free DNA and Positron Emission Tomography to Distinguish Non-Small Cell Lung Cancer from Tuberculosis. [Abstract]2023 Mar 7;54(2):130-141. PMID: 36106407 -
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Solvent & Solubility
DMSO : 41.67 mg/mL (63.65 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Protocol
T cell proliferation following mitogen stimulation is determined using [3H]-thymidine incorporation. In brief, PBMCs or purified T cells are seeded at 1×106 cells/mL in 96 well plates and stimulated with either PHA (5 μg/mL or co-stimulated with anti-CD3 mAb (5 μg/mL) and anti-CD28 mAb (2.5 μg/mL) in the presence or absence of caspase inhibitor Z-IETD-FMK. The cells are cultured for 72 h with the last 16 h pulsed with [[3H]-labelled methyl-thymidine (0.037 MBq) prior to harvest onto glass fibre filter mats using a Tomtec automated multi-well harvester[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Mice: Mice are divided into three groups: (1) naive, non-treated, mice; (2) CTR (control), i.t. instilled with NMU; and (3) lung cancer-bearing mice treated with Z-IETD-FMK (0.5 μg per mouse). The involvement of caspase-8 in lung cancer development is the determined at different time points (3, 7 and 28 days)[4].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Purity & Documentation
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Data Sheet (278 KB)
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SDS (396 KB)
- English - EN (396 KB)
- Français - FR (396 KB)
- Deutsch - DE (396 KB)
- Norwegian - NO (396 KB)
- Español - ES (396 KB)
- Swedish - SV (396 KB)
- Italian - IT (396 KB)
- Portuguese - PT (396 KB)
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Handling Instructions (2659 KB)
References
[1]. Cowburn AS, et al. z-VAD-fmk augmentation of TNF alpha-stimulated neutrophil apoptosis is compound specific and does not involve the generation of reactive oxygen species. [Content Brief]
[2]. Lawrence CP, et al. Suppression of human T cell proliferation by the caspase inhibitors, z-VAD-FMK and z-IETD-FMK is independent of their caspase inhibition properties. Toxicol Appl Pharmacol. 2012 Nov 15;265(1):103-12. [Content Brief]
[3]. Tezel G, et al. Inhibition of caspase activity in retinal cell apoptosis induced by various stimuli in vitro. Invest Ophthalmol Vis Sci. 1999 Oct;40(11):2660-7. [Content Brief]
[4]. Terlizzi M, et al. Pharmacological inhibition of caspase-8 limits lung tumour outgrowth. Br J Pharmacol. 2015 Aug;172(15):3917-28. [Content Brief]
[5]. Yang J, et al. Granzyme B Is an Essential Mediator in CD8+ T Cell Killing of Theileria parva-Infected Cells.Infect Immun. 2018 Dec 19;87(1). pii: e00386-18. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.5275 mL | 7.6373 mL | 15.2746 mL | 38.1866 mL |
| 5 mM | 0.3055 mL | 1.5275 mL | 3.0549 mL | 7.6373 mL | |
| 10 mM | 0.1527 mL | 0.7637 mL | 1.5275 mL | 3.8187 mL | |
| 15 mM | 0.1018 mL | 0.5092 mL | 1.0183 mL | 2.5458 mL | |
| 20 mM | 0.0764 mL | 0.3819 mL | 0.7637 mL | 1.9093 mL | |
| 25 mM | 0.0611 mL | 0.3055 mL | 0.6110 mL | 1.5275 mL | |
| 30 mM | 0.0509 mL | 0.2546 mL | 0.5092 mL | 1.2729 mL | |
| 40 mM | 0.0382 mL | 0.1909 mL | 0.3819 mL | 0.9547 mL | |
| 50 mM | 0.0305 mL | 0.1527 mL | 0.3055 mL | 0.7637 mL | |
| 60 mM | 0.0255 mL | 0.1273 mL | 0.2546 mL | 0.6364 mL |
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