2. Recombinant Proteins
  3. Cytokines and Growth Factors
  4. Interleukin & Receptors
  5. IL-18

IL-18

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Cat. No. Product Name / Synonyms Species Source
  • HY-P70760G
    GMP IL-18 Protein, Human (HEK293, His)

    Interleukin-18; Iboctadekin; Interferon gamma-inducing factor; IFN-gamma-inducing factor; Interleukin-1 gamma; IL-1 gamma; GIF; IL-18; IL-1g; IL1F4; MGC12320; IL18

    		Human HEK293
    IL-18 protein is a pro-inflammatory cytokine that plays a critical role in epithelial barrier repair and polarized immune responses involving Th1 cells and NK cells. After binding to IL18R1 and IL18RAP, it forms a signaling ternary complex that activates NF-kappa-B, leading to the synthesis of inflammatory mediators. GMP IL-18 Protein, Human (HEK293, His) is the recombinant human-derived IL-18 protein, expressed by HEK293 , with C-6*His labeled tag. The total length of GMP IL-18 Protein, Human (HEK293, His) is 157 a.a., with molecular weight of ~17 kDa.
  • HY-P73181
    IL-18 Protein, Mouse

    Interleukin-18; IFN-gamma-inducing factor; IL-18; IL-1 gamma; Igif; IL-1F4

    		Mouse E. coli
    IL-18 protein is a pro-inflammatory cytokine that plays an important role in epithelial barrier repair and immune response regulation by polarizing T helper 1 (Th1) cells and natural killer (NK) cells. After binding to IL18R1 and IL18RAP receptors, IL-18 forms a signaling ternary complex, activates NF-κ-B, and induces inflammatory mediators. IL-18 Protein, Mouse is the recombinant mouse-derived IL-18 protein, expressed by E. coli , with tag free. The total length of IL-18 Protein, Mouse is 157 a.a., with molecular weight of ~19 kDa.
  • HY-P70760
    IL-18 Protein, Human (HEK293, His)

    Interleukin-18; Iboctadekin; Interferon gamma-inducing factor; IFN-gamma-inducing factor; Interleukin-1 gamma; IL-1 gamma; GIF; IL-18; IL-1g; IL1F4; MGC12320; IL18

    		Human HEK293
    IL-18 protein is a pro-inflammatory cytokine that plays a critical role in epithelial barrier repair and polarized immune responses involving Th1 cells and NK cells. After binding to IL18R1 and IL18RAP, it forms a signaling ternary complex that activates NF-kappa-B, leading to the synthesis of inflammatory mediators. IL-18 Protein, Human (HEK293, His) is the recombinant human-derived IL-18 protein, expressed by HEK293 , with C-6*His labeled tag. The total length of IL-18 Protein, Human (HEK293, His) is 157 a.a., with molecular weight of ~23 kDa.
  • HY-P700108AF
    Animal-Free IL-18 Protein, Human (His)

    Interleukin-18; Iboctadekin; Interferon gamma-inducing factor; IFN-gamma-inducing factor; Interleukin-1 gamma; IL-1 gamma; GIF; IL-18; IL-1g; IL1F4; MGC12320; IL18

    		Human E. coli
    IL-18 Protein, a pro-inflammatory cytokine, plays crucial roles in epithelial barrier repair and polarized immune responses involving Th1 cells and NK cells. Upon binding to IL18R1 and IL18RAP, it forms a signaling ternary complex activating NF-kappa-B, leading to inflammatory mediator synthesis. It synergizes with IL-12 to induce IFNG synthesis in Th1 cells and NK cells. IL-18 is involved in inflammation transduction downstream of pyroptosis, released through the GSDMD pore. At the plasma membrane, IL-18 forms a ternary complex, initiating intracellular signaling, and interacts with TMED10 for translocation and secretion. Animal-Free IL-18 Protein, Human (His) is the recombinant human-derived animal-FreeIL-18 protein, expressed by E. coli, with C-His labeled tag. The total length of Animal-Free IL-18 Protein, Human (His) is 157 a.a., with molecular weight of ~19.2 kDa.
  • HY-P70591
    IL-18 Protein, Human

    Interleukin-18; Iboctadekin; Interferon gamma-inducing factor; IFN-gamma-inducing factor; Interleukin-1 gamma; IL-1 gamma; GIF; IL-18; IL-1g; IL1F4; MGC12320; IL18

    		Human E. coli
    IL-18 protein is a pro-inflammatory cytokine that plays a critical role in epithelial barrier repair and polarized immune responses involving Th1 cells and NK cells. After binding to IL18R1 and IL18RAP, it forms a signaling ternary complex that activates NF-kappa-B, leading to the synthesis of inflammatory mediators. IL-18 Protein, Human is the recombinant human-derived IL-18 protein, expressed by E. coli , with tag free. The total length of IL-18 Protein, Human is 157 a.a., with molecular weight of 17-19 kDa.
  • HY-P70642
    IL-18 Protein, Mouse (His)

    Interleukin-18; Il18; Interferon gamma-inducing factor; IFN-gamma-inducing factor; Interleukin-1 gamma; IL-1 gamma; Igif

    		Mouse E. coli
    IL-18 protein is a pro-inflammatory cytokine that plays an important role in epithelial barrier repair and immune response regulation by polarizing T helper 1 (Th1) cells and natural killer (NK) cells. After binding to IL18R1 and IL18RAP receptors, IL-18 forms a signaling ternary complex, activates NF-κ-B, and induces inflammatory mediators. IL-18 Protein, Mouse (His) is the recombinant mouse-derived IL-18 protein, expressed by E. coli , with N-6*His labeled tag. The total length of IL-18 Protein, Mouse (His) is 157 a.a., with molecular weight of ~20.0 kDa.
  • HY-P73182
    IL-18 Protein, Rhesus Macaque (His)

    Interleukin-18; IFN-gamma-inducing factor; IL-18; IL-1 gamma; Igif; IL-1F4

    		Rhesus Macaque E. coli
    IL-18 Protein, a pro-inflammatory cytokine, crucially participates in epithelial barrier repair and modulates immune responses, particularly in Th1 cell and NK cell immune responses. Binding to IL18R1 and IL18RAP receptors, IL-18 forms a signaling ternary complex activating NF-kappa-B, inducing inflammatory mediators. Synergizing with IL-12, it stimulates IFNG synthesis from Th1 cells and NK cells. Additionally, IL-18 is involved in transducing inflammation during pyroptosis, releasing its mature form through the gasdermin-D (GSDMD) pore. IL-18 Protein, Rhesus Macaque (His) is the recombinant Rhesus Macaque-derived IL-18 protein, expressed by E. coli, with N-6*His, labeled tag. The total length of IL-18 Protein, Rhesus Macaque (His) is 192 a.a., with molecular weight of ~24.39 kDa.
  • HY-P70642AF
    Animal-Free IL-18 Protein, Mouse (His)

    Interleukin-18; Il18; Interferon gamma-inducing factor; IFN-gamma-inducing factor; Interleukin-1 gamma; IL-1 gamma; Igif

    		Mouse E. coli
    IL-18 Protein, a pro-inflammatory cytokine, crucially participates in epithelial barrier repair and immune response modulation by polarizing T-helper 1 (Th1) cells and natural killer (NK) cells. Upon binding to IL18R1 and IL18RAP receptors, IL-18 forms a signaling ternary complex activating NF-kappa-B, inducing inflammatory mediators. It synergizes with IL-12 to stimulate IFNG synthesis from Th1 cells and NK cells. IL-18 is also involved in transducing inflammation during pyroptosis, with its mature form released through the gasdermin-D (GSDMD) pore. At the plasma membrane, IL-18 forms a ternary complex with IL18R1 and IL18RAP, signaling within the cell. Additionally, IL-18 interacts with the cargo receptor TMED10 for secretion from the cytoplasm to the endoplasmic reticulum-Golgi intermediate compartment (ERGIC). Animal-Free IL-18 Protein, Mouse (His) is the recombinant mouse-derived animal-FreeIL-18 protein, expressed by E. coli, with C-His labeled tag. The total length of Animal-Free IL-18 Protein, Mouse (His) is 157 a.a., with molecular weight of ~19.1 kDa.
  • HY-P7210
    IL-18 Protein, Rat

    rRtIL-18; Interferon-gamma-inducing factor; IL-1 gamma

    		Rat E. coli
    IL-18 Protein, Rat possesses immunoregulatory activities, including the stimulation of interferon (IFN)-γ production by T helper 1 (Th1) and natural killer cells, as well as other activities that promote inflammation.
  • HY-P70591A
    IL-18 Protein, Human (N-His)

    Interleukin-18; Iboctadekin; Interferon gamma-inducing factor; IFN-gamma-inducing factor; Interleukin-1 gamma; IL-1 gamma; GIF; IL-18; IL-1g; IL1F4; MGC12320; IL18

    		Human E. coli
    IL-18 protein is a pro-inflammatory cytokine that plays a critical role in epithelial barrier repair and polarized immune responses involving Th1 cells and NK cells. After binding to IL18R1 and IL18RAP, it forms a signaling ternary complex that activates NF-kappa-B, leading to the synthesis of inflammatory mediators. IL-18 Protein, Human (N-His) is the recombinant human-derived IL-18 protein, expressed by E. coli , with N-6*His labeled tag. The total length of IL-18 Protein, Human (N-His) is 157 a.a., with molecular weight of ~20 kDa.
  • HY-P71657
    IL-18 Protein, Dog (His)

    IL18; IGIF; Interleukin-18; IL-18; Interferon gamma-inducing factor; IFN-gamma-inducing factor; Interleukin-1 gamma; IL-1 gamma

    		Dog E. coli
    IL-18 protein is a pro-inflammatory cytokine that is critical for epithelial barrier repair and immune regulation, especially in Th1 and NK cell responses. IL18R1 and IL18RAP combine to form a signaling ternary complex that activates NF-kappa-B and induces inflammatory mediators. IL-18 Protein, Dog (His) is the recombinant dog-derived IL-18 protein, expressed by E. coli , with N-His labeled tag. The total length of IL-18 Protein, Dog (His) is 157 a.a., with molecular weight of ~22.0 kDa.
Cat. No. Product Name Effect Purity