Molecular Interaction Assay Services
Affinity is a crucial parameter for assessing molecular interactions and serves as an essential key in identifying biological processes and drug discovery. To evaluating drug efficacy and the stability of biological macromolecules and their complexes, comprehensive studies encompassing kinetics, thermodynamics, and thermal stability is required, focusing on binding occurrence, binding speed, and binding strength. MCE offers a professional molecular interaction detection platform including Surface Plasmon Resonance (SPR), Bio - Layer Interferometry (BLI), Isothermal Titration Calorimetry (ITC), Microscale Thermophoresis (MST) and Nano Differential Scanning Fluorimetry (nanoDSF). Coupled with professional services of virtual screening ,protein expression and purification, we provide a one-stop solution for drug discovery!
Key features and Compatible Sample Types
| Method | Key features | Results | Applicable sample types |
|---|---|---|---|
| SPR |
• Label-Free Detection • Real-Time Monitoring • High Sensitivity • Low sample consumption • High-Throughput Detection |
KD Ka (Kon) Kd (Koff) |
• Proteins • DNA/RNA • Lipids • Polysaccharides • Peptides • Small molecules • Cell Lysate …… |
| MST |
• Low sample consumption • Short measurement time • Analysis in complex buffers • No need for sample immobilization • High sample compatibility |
KD | |
| BLI |
• Label-free detection • Low sample consumption with high sensitivity • Real-Time Monitoring • Wide range of applications • High-throughput detection |
KD Ka (Kon) Kd (Koff) |
|
| ITC |
• No fluorescent labeling or immobilization required for samples • High sensitivity and precision • Thermodynamic properties can be measured |
KD n (stoichiometry) ΔH (enthalpy) ΔS (entropy) |
|
| nanoDSF |
• No fluorescent labeling or immobilization required for samples • High throughput • Low sample consumption |
Tm |
and Equipment
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Solutions Offering
Advanced Instrumentation and Equipment
Professional Technical Team
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