Adhesion GPCRs
Adhesion GPCRs form Class B2 of the GPCR superfamily and are defined by a large extracellular N-terminal region plus a conserved GAIN domain, which in many members carries out autoproteolysis and stows a tethered agonist peptide. The 33 human members, named ADGRs (for example ADGRG1/GPR56 and ADGRF1/GPR110), often bind extracellular matrix or cell-surface ligands such as collagen and transduce contact-dependent mechanical or migratory cues. They activate G12/13, Gq and other G proteins and govern neural development, myelination, angiogenesis and tissue polarity. Loss-of-function mutations in ADGRG1 cause bilateral frontoparietal polymicrogyria, a severe cortical malformation, exemplifying the subfamily's developmental importance.
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Adhesion GPCRs Recombinant Proteins (7)
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Recombinant Protein Expression Service
- Codon Optimization
- Gene Synthesis
- Construction of Expression Vector
- Strain Screening
- Protein Expression
- Purification & QC
- Protein Delivery
- Formula: Human
- Molecular Weight: Sf9 insect cells
The EpCAM/TROP1 protein serves as an important homogeneous interacting molecule that promotes direct contact between intestinal epithelial cells (IEC) and intraepithelial lymphocytes (IEL) in the mucosal epithelium. This feature helps establish an immune barrier against mucosal infections. EpCAM/TROP1 Protein, Human (His-SUMO) is the recombinant human-derived EpCAM/TROP1 protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag.
