Signaling Pathway

Calcium Channel

Calcium Channel

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Calcium channel is an ion channel which displays selective permeability to calcium ions. It is sometimes synonymous as voltage-dependent calcium channel, although there are also ligand-gated calcium channels. Voltage-gated calcium (CaV) channels catalyse rapid, highly selective influx of Ca2+into cells despite a 70-fold higher extracellular concentration of Na+. Some calcium channel blockers have the added benefit of slowing your heart rate, which can further reduce blood pressure, relieve chest pain (angina) and control an irregular heartbeat.

Calcium Channel Inhibitors & Modulators (62)

Product Name Catalog No. Brief Description
ABT-639

HY-19721

ABT-639 is a novel, peripherally acting, selective T-type Ca2+ channel blocker.

Acetylcholine chloride

HY-B0282

Acetylcholine is a neurotransmitter that can induce the opening of calcium channels.

Amlodipine

HY-B0317

Amlodipine is a long-acting calcium channel blocker.

Amlodipine besylate

HY-B0317B

Amlodipine besylate is a long-acting calcium channel blocker.

Amlodipine maleate

HY-B0317A

Amlodipine maleate is a long-acting calcium channel blocker.

Azelnidipine

HY-B0023

Azelnidipine(CS 905; Calblock) is a novel dihydropyridine derivative, a L-type calcium channel blocker, and an antihypertensive.

Azelnidipine D7

HY-B0023S

Azelnidipine D7 is deuterium labeled Azelnidipine, which is a L-type calcium channel blocker.

Bay-K-8644 (R)-(+)-

HY-15125

Bay-K-8644 ((R)-(+)-) is a Ca2+ channel activator; L-type Ca2+ channel activator.

Bay-K-8644 (S)-(-)-

HY-15124

Bay-K-8644 ((S)-(-)-) is a Ca2+ channel activator; L-type Ca2+ channel activator.

Benidipine hydrochloride

HY-B1448

Benidipine hydrochloride is a dihydropyridine calcium channel blocker for the treatment of high blood pressure (hypertension).

Ca2+ channel agonist 1

HY-41076

Ca2+ channel agonist 1 is a N-type Ca2+ channel activity agonist, with EC50 of 14.23 uM, also inhibits cdk2 kinase activity with EC50 of 3.34 uM.

Chlorpromazine D6 hydrochloride

HY-B0407AS

Chlorpromazine D6 hydrochloride is the deuterium labeled Chlorpromazine, which is a dopamine and potassium channel inhibitor

Chlorpromazine hydrochloride

HY-B0407A

Chlorpromazine Hydrochloride is a dopamine and potassium channel inhibitor used as the prototypical phenothiazine antipsychotic drug.

Cilnidipine

HY-17404

Cilnidipine(FRC8653) is a dual L- and N-type calcium channel blocker and displays antihypertensive, sympatholytic and neuroprotective activity.

Cinnarizine

HY-B1090

Cinnarizine is an antihistamine and a calcium channel blocker, promote cerebral blood flow, used to treat cerebral apoplexy, post-trauma cerebral symptoms, and cerebral arteriosclerosis.

Clevidipine

HY-17436

Clevidipine is a short-acting dihydropyridine calcium channel antagonist (IC50= 7.1 nM, V(H) = -40 mV ) under development for treatment of perioperative hypertension.

Cromolyn sodium

HY-B0320A

Cromolyn sodium is an antiallergic drug.

Dantrolene sodium

HY-14657

Dantrolene sodium is a inhibitor of calcium channel proteins, inhibiting the release of Ca2+ from the sarcoplasm.

Dantrolene sodium hemiheptahydrate

HY-12542A

Dantrolene sodium hemiheptahydrate is a skeletal muscle relaxant which acts by blocking muscle contraction beyond the neuromuscular junction.

Diltiazem hydrochloride

HY-14656

Diltiazem hydrochloride is a benzothiazepine derivative with vasodilating action due to its antagonism of the actions of the calcium ion in membrane functions.