1. Signaling Pathways
  2. Membrane Transporter/Ion Channel
  3. Calcium Channel

Calcium Channel

Calcium channel is an ion channel which displays selective permeability to calcium ions. It is sometimes synonymous as voltage-dependent calcium channel, although there are also ligand-gated calcium channels. Voltage-gated calcium (CaV) channels catalyse rapid, highly selective influx of Ca2+ into cells despite a 70-fold higher extracellular concentration of Na+. Some calcium channel blockers have the added benefit of slowing your heart rate, which can further reduce blood pressure, relieve chest pain (angina) and control an irregular heartbeat.

Calcium Channel Related Products (123):

Cat. No. Product Name Effect Purity
  • HY-B0470
    Neomycin sulfate Inhibitor >98.0%
    Neomycin sulfate is an aminoglycoside antibiotic used for preventing or treating bacterial infections.
  • HY-A0064
    Verapamil hydrochloride Antagonist 99.95%
    Verapamil hydrochloride is a calcium channel antagonist.
  • HY-B0284
    Nifedipine Antagonist
    Nifedipine (BAY-a-1040) is a potent calcium channel blocker and drug of choice for cardiac insufficiencies.
  • HY-13434
    Ionomycin >98.0%
    Ionomycin (SQ23377) is a Calcium ionophore and an antibiotic produced by Streptomyces conglobatus ATCC 31005.
  • HY-10341
    Fasudil Hydrochloride Antagonist 99.91%
    Fasudil Hydrochloride (HA-1077 Hydrochloride; AT-877 Hydrochloride), a potent inhibitor of ROCK with a Ki of 0.33 μM for ROCK1, which is also a potent Ca2+ channel antagonist and vasodilator.
  • HY-14744A
    Levamlodipine besylate Inhibitor 99.91%
    Levamlodipine besylate ((S)-Amlodipine besylate) is a powerful dihydropyridine calcium channel blocker, possessing vasodilation properties and used in the treatment of hypertension and angina.
  • HY-B0106A
    Etiracetam Agonist 99.91%
    Etiracetam (UCB 6474) is an acetylcholine agonist and a nootropic drug of the racetam family. Less active than its S-enantiomer Levetiracetam (UCB L059).
  • HY-B1671
    (+)-Kavain 99.98%
    (+)-Kavain, a main kavalactone extracted from Piper methysticum, has anticonvulsive properties, attenuating vascular smooth muscle contraction through interactions with voltage-dependent Na+ and Ca2+ channels. (+)-Kavain is shown to bind at the α4β2δ GABAA receptor and potentiate GABA efficacy. (+)-Kavain is used as a treatment for inflammatory diseases, its anti-inflammatory action has been widely studied.
  • HY-13433
    Thapsigargin Inhibitor >99.0%
    Thapsigargin is an inhibitor of microsomal Ca2+-ATPase.
  • HY-B0282
    Acetylcholine chloride Activator >98.0%
    Acetylcholine (chloride) is a common neurotransmitter found in the central and peripheral nerve system.
  • HY-15553A
    Mibefradil dihydrochloride Inhibitor 99.63%
    Mibefradil dihydrochloride (Ro 40-5967 dihydrochloride) is a calcium channel blocker with moderate selectivity for T-type Ca2+ channels displaying IC50s of 2.7 μM and 18.6 μM for T-type and L-type currents, respectively.
  • HY-B0265
    Nimodipine Inhibitor 99.87%
    Nimodipine(Nimotop) is a dihydropyridine derivative and an analogue of the calcium channel blocker nifedipine, with antihypertensive activity.
  • HY-101455
    CDN1163 Activator 99.12%
    CDN1163 is a sarco/endoplasmic reticulum Ca2+-ATPase (SERCA) activator.
  • HY-15124
    (S)-(-)-Bay-K-8644 Agonist 98.34%
    (S)-(-)-Bay-K-8644 is an agonist of L-type Ca2+ channel. (S)-(-)-Bay-K-8644 activates Ba2+ currents (IBa) (EC50=32 nM).
  • HY-12507
    GSK-7975A Inhibitor 99.56%
    GSK-7975A is a potent and orally available CRAC channel inhibitor.
  • HY-14656
    Diltiazem hydrochloride Antagonist 98.39%
    Diltiazem hydrochloride is a Ca2+ influx inhibitor (slow channel blocker or calcium antagonist).
  • HY-B1221
    Flufenamic acid Inhibitor 99.92%
    Flufenamic acid is a non-steroidal anti-inflammatory agent, inhibits cyclooxygenase (COX), activates AMPK, and also modulates ion channels, blocking chloride channels and L-type Ca2+ channels, modulating non-selective cation channels (NSC), activating K+ channels.
  • HY-12542A
    Dantrolene sodium hemiheptahydrate Inhibitor >98.0%
    Dantrolene sodium hemiheptahydrate is a skeletal muscle relaxant which acts by blocking muscle contraction beyond the neuromuscular junction.
  • HY-B0320A
    Cromolyn sodium Inhibitor 99.97%
    Cromolyn sodium is an antiallergic drug. Cromolyn sodium is a GSK-3β inhibitor with an IC50 of 2.0 µM.
  • HY-17401
    Ranolazine dihydrochloride Inhibitor 99.92%
    Ranolazine dihydrochloride (RS-43285) is an antianginal agent with antiarrhythmic properties that achieves its effects via a novel mechanism of action (inhibition of the late phase of the inward sodium current), without affecting heart rate or blood pressure (BP).
Isoform Specific Products

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