1. Membrane Transporter/Ion Channel
  2. Calcium Channel

Calcium Channel

Calcium channel is an ion channel which displays selective permeability to calcium ions. It is sometimes synonymous as voltage-dependent calcium channel, although there are also ligand-gated calcium channels. Voltage-gated calcium (CaV) channels catalyse rapid, highly selective influx of Ca2+ into cells despite a 70-fold higher extracellular concentration of Na+. Some calcium channel blockers have the added benefit of slowing your heart rate, which can further reduce blood pressure, relieve chest pain (angina) and control an irregular heartbeat.

Calcium Channel Related Products (65):

Cat. No. Product Name Effect Purity
  • HY-A0064
    Verapamil hydrochloride Antagonist
    Verapamil hydrochloride is an L-type calcium channel antagonist.
  • HY-15553A
    Mibefradil dihydrochloride Inhibitor
    Mibefradil dihydrochloride is a calcium channel blocker with moderate selectivity for T-type Ca2+ channels displaying IC50s of 2.7 μM and 18.6 μM for T-type and L-type currents, respectively.
  • HY-14656
    Diltiazem hydrochloride Antagonist
    Diltiazem hydrochloride is a Ca2+ influx inhibitor (slow channel blocker or calcium antagonist).
  • HY-15124
    Bay-K-8644 (S)-(-)- Activator
    Bay-K-8644 ((S)-(-)-) is a Ca2+ channel activator; L-type Ca2+ channel activator.
  • HY-17404
    Cilnidipine Inhibitor
    Cilnidipine(FRC8653) is a dual L- and N-type calcium channel blocker and displays antihypertensive, sympatholytic and neuroprotective activity.
  • HY-11013
    ZSET1446 Activator
    ZSET1446 is a novel cognitive enhancer that significantly improves learning deficits in various types of Alzheimer disease (AD) models.
  • HY-15125
    Bay-K-8644 (R)-(+)- Activator
    Bay-K-8644 ((R)-(+)-) is a Ca2+ channel activator; L-type Ca2+ channel activator.
  • HY-B0106
    Levetiracetam Inhibitor
    Levetiracetam(UCB L059) is a novel anticonvulsant with antihyperalgesic efficacy in inflammatory pain.
  • HY-17401
    Ranolazine dihydrochloride Inhibitor
    Ranolazine(RS-43285) is an antianginal agent with antiarrhythmic properties that achieves its effects via a novel mechanism of action (inhibition of the late phase of the inward sodium current), without affecting heart rate or blood pressure (BP).
  • HY-B0265
    Nimodipine Inhibitor
    Nimodipine(Nimotop) is a dihydropyridine derivative and an analogue of the calcium channel blocker nifedipine, with antihypertensive activity.Nimodipine decreases intracellular free Ca2+,Beclin-1 and autophagy.
  • HY-B0233
    Isradipine Inhibitor
    Isradipine(Dynacirc) is a calcium channel blocker with an IC50 of 34±8 μM.
  • HY-B0023
    Azelnidipine Inhibitor
    Azelnidipine(CS 905; Calblock) is a novel dihydropyridine derivative, a L-type calcium channel blocker, and an antihypertensive.
  • HY-17403
    Manidipine dihydrochloride Inhibitor
    Manidipine 2Hcl (CV-4093) is a dihydropyridine compound and a calcium channel blocker for Ca2+ current with IC50 of 2.6 nM.
  • HY-A0057A
    Gabapentin hydrochloride Inhibitor
    Gabapentin (Neurontin) is a pharmaceutical drug, specifically a GABA analog. It was originally developed to treat epilepsy, and currently is also used to relieve neuropathic pain.
  • HY-14462
    NP118809 Inhibitor
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  • HY-17402
    Nisoldipine Inhibitor
    Nisoldipine(BAY-k 5552; Sular) is a calcium channel blocker belonging to the dihydropyridines class, specific for L-type Cav1.2 with IC50 of 10 nM.
  • HY-17436
    Clevidipine Antagonist
    Clevidipine is a short-acting dihydropyridine calcium channel antagonist (IC50= 7.1 nM, V(H) = -40 mV ) under development for treatment of perioperative hypertension.
  • HY-15553
    Mibefradil Inhibitor
    Mibefradil(Ro 40-5967) is calcium channel blocker with moderate selectivity for T-type Ca2+ channels displaying IC50 values of 2.7 μM and 18.6 μM for T-type and L-type channels respectively.
  • HY-B0124
    Zonisamide Inhibitor
    Zonisamide is a 1,2 benzisoxazole derivative and the first agent of this chemical class to be developed as an antiepileptic drug.
  • HY-14284
    Nilvadipine Antagonist
    Nilvadipine is a potent calcium channel antagonist, and the IC50 value is around 0.1 nM.