1. Membrane Transporter/Ion Channel
    Neuronal Signaling
    Metabolic Enzyme/Protease
  2. nAChR
    Calcium Channel
    Endogenous Metabolite
  3. Acetylcholine chloride

Acetylcholine chloride  (Synonyms: ACh chloride)

Cat. No.: HY-B0282 Purity: ≥98.0%
COA Handling Instructions

Acetylcholine chloride (ACh chloride), a neurotransmitter, is a potent cholinergic agonist. Acetylcholine chloride is a modulator of the activity of dopaminergic (DAergic) neurons through the stimulation of nicotinic acetylcholine receptors (nAChRs). Acetylcholine chloride inhibits p53 mutant peptide aggregation in vitro.

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Acetylcholine chloride Chemical Structure

Acetylcholine chloride Chemical Structure

CAS No. : 60-31-1

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10 mM * 1 mL in DMSO USD 55 In-stock
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Based on 2 publication(s) in Google Scholar

Other Forms of Acetylcholine chloride:

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Description

Acetylcholine chloride (ACh chloride), a neurotransmitter, is a potent cholinergic agonist. Acetylcholine chloride is a modulator of the activity of dopaminergic (DAergic) neurons through the stimulation of nicotinic acetylcholine receptors (nAChRs)[1][2]. Acetylcholine chloride inhibits p53 mutant peptide aggregation in vitro[5].

IC50 & Target[1][5]

Human Endogenous Metabolite

 

In Vitro

Acetylcholine chloride (ACh chloride; 10 μM) opens the calcium channel and the fluorescence value and intracellular free calcium will increase significantly when the medium is with high calcium, while these will decrease when the medium is without calcium in sweat gland epithelial cells[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Acetylcholine chloride (ACh chloride; SC; 20 mg/kg; single dose) induces pronounced cholinergic stimulation and increase of mouse survival in experimental infection[4].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male and female out-bred albino mice weighing 18-22 g (sepsis)[4]
Dosage: 20 mg/kg
Administration: SC; single dose
Result: Significantly reduces mortality of mice from sepsis induced by intraperitoneal injection of 2×109 E. coli bacterial bodies and the blood levels of proinflammatory cytokines TNF-α, IL-1β, and IL-6.
Clinical Trial
Molecular Weight

181.66

Formula

C7H16ClNO2

CAS No.
SMILES

O=C(OCC[N+](C)(C)C)C.[Cl-]

Structure Classification
Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Solvent & Solubility
In Vitro: 

H2O : 100 mg/mL (550.48 mM; Need ultrasonic)

DMSO : 62.5 mg/mL (344.05 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 5.5048 mL 27.5239 mL 55.0479 mL
5 mM 1.1010 mL 5.5048 mL 11.0096 mL
10 mM 0.5505 mL 2.7524 mL 5.5048 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  PBS

    Solubility: 23.33 mg/mL (128.43 mM); Clear solution; Need ultrasonic

  • 2.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.08 mg/mL (11.45 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.08 mg/mL (11.45 mM); Clear solution

  • 4.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.08 mg/mL (11.45 mM); Clear solution

*All of the co-solvents are available by MCE.
Purity & Documentation

Purity: ≥98.0%

References
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Product Name:
Acetylcholine chloride
Cat. No.:
HY-B0282
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