Acetylcholine-d4 chloride
Based on 1 Customer Validation
Acetylcholine-d4 (chloride) is the deuterium labeled Acetylcholine chloride. Acetylcholine chloride (ACh chloride), a neurotransmitter, is a potent and BBB-permeable cholinergic agonist. Acetylcholine chloride is a modulator of the activity of dopaminergic (DAergic) neurons through the stimulation of nicotinic acetylcholine receptors (nAChRs). Acetylcholine chloride inhibits p53 mutant peptide aggregation in vitro.
For research use only. We do not sell to patients.
- Purity: 98.0%
- CAS No.: 344298-94-8
- Formula: C7H12D4ClNO2
- Molecular Weight:185.69
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Storage:
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
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Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
1. This compound can be used as a tracer
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
Chemical Information
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CAS No. 344298-94-8
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Unlabeled Cas 60-31-1
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Appearance Solid
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Molecular Weight 185.69
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Formula C7H12D4ClNO2
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Color White to off-white
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SMILES
CC(OC([2H])([2H])C([2H])([2H])[N+](C)(C)C)=O.[Cl-]
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Synonyms
ACh-d4 chloride
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Solvent & Solubility
H2O : 100 mg/mL (538.53 mM; Need ultrasonic)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (275 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [Content Brief]
[3]. A Young, et al. Diarrhoea of famine and malnutrition--investigations using a rat model. 2--Ileal hypersecretion induced by starvation. Gut. 1990 Feb;31(2):162-9. [Content Brief]
[4]. Xia Lei, et al. Effects of acetylcholine chloride on intracellular calcium concentration of cultured sweat gland epithelial cells. Arch Dermatol Res. 2008 Aug;300(7):335-41. [Content Brief]
[5]. P F Zabrodskii, et al. Effect of acetylcholine on mortality of mice from sepsis and proinflammatory cytokine production. Bull Exp Biol Med. 2011 Jan;150(3):340-2. [Content Brief]
[6]. Zhaolin Chen, et al. Inhibition of p53 Mutant Peptide Aggregation In Vitro by Cationic Osmolyte Acetylcholine Chloride. Protein Pept Lett. 2017;24(4):353-357. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O | 1 mM | 5.3853 mL | 26.9266 mL | 53.8532 mL | 134.6330 mL |
| 5 mM | 1.0771 mL | 5.3853 mL | 10.7706 mL | 26.9266 mL | |
| 10 mM | 0.5385 mL | 2.6927 mL | 5.3853 mL | 13.4633 mL | |
| 15 mM | 0.3590 mL | 1.7951 mL | 3.5902 mL | 8.9755 mL | |
| 20 mM | 0.2693 mL | 1.3463 mL | 2.6927 mL | 6.7316 mL | |
| 25 mM | 0.2154 mL | 1.0771 mL | 2.1541 mL | 5.3853 mL | |
| 30 mM | 0.1795 mL | 0.8976 mL | 1.7951 mL | 4.4878 mL | |
| 40 mM | 0.1346 mL | 0.6732 mL | 1.3463 mL | 3.3658 mL | |
| 50 mM | 0.1077 mL | 0.5385 mL | 1.0771 mL | 2.6927 mL | |
| 60 mM | 0.0898 mL | 0.4488 mL | 0.8976 mL | 2.2439 mL | |
| 80 mM | 0.0673 mL | 0.3366 mL | 0.6732 mL | 1.6829 mL | |
| 100 mM | 0.0539 mL | 0.2693 mL | 0.5385 mL | 1.3463 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
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