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Recent Posts
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Conserved Antiviral Immunity Across Domains of Life: From Pathogen Sensing to Effector ResponsesExplore conserved antiviral mechanisms across mammals and bacteria, from virus recognition and immune signaling to metabolic defense and gasdermin-mediated cell death, and their implications for innate immune evolution.
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Mitochondrial Control of Cellular Senescence: Quality Control, Innate Immunity, and Metabolic–Epigenetic RegulationExplore how mitochondrial quality control, inflammatory signaling, and metabolic–epigenetic reprogramming regulate cellular senescence and the SASP, along with strategies to restore mitochondrial homeostasis.
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Beyond One Brake: How Tumors Dynamically Rewire the Immune Checkpoint NetworkExplore the mechanisms of tumor immune evasion, dynamic checkpoint regulation, and the evolution of mechanism-driven combinations and patient stratification.
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Evolution of PCSK9 Inhibitors Modalities: From Monoclonal Antibodies to Oral Macrocyclic PeptidesReview the biological basis of PCSK9, key therapeutic modalities, cardiovascular evidence, and future directions, including insights from the CORALreef clinical program.
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Engineering mRNA Therapeutics: Molecular Design, Targeted Delivery, and Translational ChallengesExplore advances in mRNA molecular design and targeted delivery, emerging non-LNP platforms, and key translational challenges shaping broader applications beyond vaccines.
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Beyond Aβ Clearance: Exploring Multi-Pathology Strategies in Alzheimer’s DiseaseExplore how anti-Aβ therapy is reshaping the AD treatment landscape, the rationale for multi-pathology combination strategies, and advances in biomarker-guided precision treatment.