1. Anti-infection
  2. HIV

HIV

HIV (Human immunodeficiency virus) is a lentivirus (a subgroup of retrovirus) that causes the acquired immunodeficiency syndrome (AIDS), a condition in humans in which progressive failure of the immune system allows life-threatening opportunistic infections and cancers to thrive. Infection with HIV occurs by the transfer of blood, semen, vaginal fluid, pre-ejaculate, or breast milk. Within these bodily fluids, HIV is present as both free virus particles and virus within infected immune cells. HIV infects vital cells in the human immune system such as helper T cells (specifically CD4+ T cells), macrophages, and dendritic cells. HIV infection leads to low levels of CD4+ T cells through a number of mechanisms, including apoptosis of uninfected bystander cells, direct viral killing of infected cells, and killing of infected CD4+ T cells by CD8 cytotoxic lymphocytes that recognize infected cells. When CD4+ T cell numbers decline below a critical level, cell-mediated immunity is lost, and the body becomes progressively more susceptible to opportunistic infections.

HIV Related Products (77):

Cat. No. Product Name Effect Purity
  • HY-13238
    Dolutegravir Inhibitor
    Dolutegravir is an inhibitor of HIV-1 integrase-catalyzed strand transfer with IC50 of 2.7 nM.
  • HY-14740
    Elvitegravir Inhibitor
    Elvitegravir is an HIV integrase inhibitor for HIV-1IIIB, HIV-2EHO and HIV-2ROD with IC50 of 0.7 nM, 2.8 nM and 1.4 nM, respectively.
  • HY-15148
    Tipranavir Inhibitor
    Tipranavir inhibits the enzymatic activity and dimerization of HIV-1 protease, exerts potent activity against multi-protease inhibitor (PI)-resistant HIV-1 isolates with IC50s of 66-410 nM.
  • HY-10572
    Efavirenz Inhibitor
    Efavirenz is a potent inhibitor of the wild-type HIV-1 RT (Ki=2.93 nM) and exhibits IC95 of 1.5 nM for the inhibition of HIV-1 replicative spread in cell culture.
  • HY-90001
    Ritonavir Inhibitor
    Ritonavir is an inhibitor of HIV protease used to treat HIV infection and AIDS.
  • HY-17007
    Saquinavir Inhibitor
    Saquinavir(Ro 31-8959) is an HIV Protease inhibitor used in antiretroviral therapy.
  • HY-14267
    Lersivirine Inhibitor
    Lersivirine(UK-453061) is a next-generation non-nucleoside reverse transcriptase inhibitor (NNRTI, IC50=119 nM) with a unique resistance profile that exhibits potent antiretroviral activity against wild-type human immunodeficiency virus and clinically relevant NNRTI-resistant strains.
  • HY-13231
    CDK9-IN-1 Inhibitor
    CDK9-IN-1 is a novel, selective CDK9 inhibitor for the treatment of HIV infection.
  • HY-10353A
    Raltegravir potassium salt Inhibitor
    Raltegravir (potassium salt) is a potent integrase (IN) inhibitor, used to treat HIV infection.
  • HY-14588
    Lopinavir Inhibitor
    Lopinavir is a potent HIV protease inhibitor with Ki of 1.3 pM.
  • HY-10570
    Nevirapine Inhibitor
    Nevirapine is a potent, non-nucleoside reverse transcriptase inhibitor (NNRTI) used in combination with nucleoside analogues for treatment of HIV-1 infection and AIDS.
  • HY-90005
    Etravirine Inhibitor
    Etravirine is a non-nucleoside reverse transcriptase inhibitor (NNRTI) used for the treatment of HIV.
  • HY-17003
    Saquinavir Mesylate Inhibitor
    Saquinavir mesylate is an HIV Protease Inhibitor used in antiretroviral therapy.
  • HY-10574
    Rilpivirine Inhibitor
    Rilpivirine(R 278474, TMC 278) is a type of anti-HIV medicine called a non-nucleoside reverse transcriptase inhibitor (NNRTI).
  • HY-14134
    BMS-378806 Inhibitor
    BMS-378806 is a potent HIV-1 attachment inhibitor that interferes with CD4-gp120 interactions. BMS-378806 selectively inhibits the binding of HIV-1 gp120 to the CD4 receptor with EC50 of 0.85-26.5 nM in virus.
  • HY-15232
    GS-7340 Inhibitor
    GS-7340(Tenofovir alafenamide) is a prodrug of tenofovir (TFV) that more efficiently delivers TFV into lymphoid cells and tissues than TFV disoproxil fumarate.
  • HY-10522
    HIV-1 integrase inhibitor 2 Inhibitor
    HIV-1 integrase inhibitor, in the treatment of human immunodeficiency virus (HIV) infection.
  • HY-11019
    BMS-538203 Inhibitor
    BMS-538203 is a highly efficient HIV integrase inhibitor and antiviral agent.
  • HY-76648
    NBD-556 Inhibitor
    NBD-556 is small molecule mimetic of CD4, NBD-556 recognizes the HIV-1 envelope protein gp120 and induces restructuring of gp120 analogous to CD4 binding.
  • HY-13025
    HIV-1 integrase inhibitor Inhibitor
    HIV-1 integrase inhibitor ((Z)-4-(3-(azidomethyl)phenyl)-2-hydroxy-4-oxobut-2-enoic acid) is uesful for anti-HIV.