Signaling Pathway

HIV

HIV

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The human immunodeficiency virus (HIV) is a lentivirus (a subgroup of retrovirus) that causes the acquired immunodeficiency syndrome (AIDS), a condition in humans in which progressive failure of the immune system allows life-threatening opportunistic infections and cancers to thrive. Infection with HIV occurs by the transfer of blood, semen, vaginal fluid, pre-ejaculate, or breast milk. Within these bodily fluids, HIV is present as both free virus particles and virus within infected immune cells. HIV infects vital cells in the human immune system such as helper T cells (specifically CD4+ T cells), macrophages, and dendritic cells. HIV infection leads to low levels of CD4+ T cells through a number of mechanisms, including apoptosis of uninfected bystander cells, direct viral killing of infected cells, and killing of infected CD4+ T cells by CD8 cytotoxic lymphocytes that recognize infected cells. When CD4+ T cell numbers decline below a critical level, cell-mediated immunity is lost, and the body becomes progressively more susceptible to opportunistic infections.

HIV Inhibitors & Modulators (75)

Product Name Catalog No. Brief Description
(±)-BI-D

HY-18601

(±)-BI-D is a potent ALLINI(An allosteric IN inhibitor) that binds integrase at the LEDGF/p75 binding site.

Abacavir

HY-17423

Abacavir is a powerful nucleoside analog reverse transcriptase inhibitor (NRTI) used to treat HIV and AIDS.

AMD 3465

HY-15971A

AMD 3465(GENZ-644494) is a potent, selective CXCR4 antagonist; exhibits 8-fold higher affinity than AMD 3100; inhibits SDF-1α-ligand binding (Ki = 41.7 nM).

AMD 3465 hexahydrobromide

HY-15971

AMD 3465 6HBr(GENZ-644494) is a potent, selective CXCR4 antagonist; exhibits 8-fold higher affinity than AMD 3100; inhibits SDF-1α-ligand binding (Ki = 41.7 nM).

Amprenavir

HY-17430

Amprenavir (Agenerase) is a HIV protease inhibitor(Ki=0.6 nM) used to treat HIV infection.

Atazanavir

HY-17367

Atazanavir(BMS-232632) is an highly potent HIV-1 protease inhibitor.

Atazanavir sulfate

HY-17367A

Atazanavir sulfate is a sulfate salt form of atazanavir that is an highly potent HIV-1 protease inhibitor.

Bevirimat

HY-N0842

Bevirimat(YK FH312; FH11327; MPC-4326) is an anti-HIV drug derived from a betulinic acid-like compound; is believed to inhibit HIV by a novel mechanism, so-called maturation inhibition.

BI 224436

HY-18595

BI 224436 is a novel HIV-1 non-catalytic-site integrase inhibitor; has antiviral EC50s of <15 nM against different HIV-1 laboratory strains and cellular cytotoxicity of >90 μM.

BMS-378806

HY-14134

BMS-806 (BMS 378806) is a small molecule gp120/CD4 inhibitor with an IC50 of median 5 nM.

BMS-538203

HY-11019

BMS-538203 is a  highly efficient HIV integrase inhibitor and antiviral agent.

BMS-626529

HY-15440

BMS-626529 is a novel small-molecule attachment inhibitor that targets HIV-1 gp120 and prevents its binding to CD4+ T-cells.

BMS-663068

HY-15440A

BMS-663068 is an HIV-1 attachment inhibitor in development for the treatment of HIV-1 infection.

BMS-663068 Tris

HY-15440B

BMS-663068 tris is an HIV-1 attachment inhibitor in development for the treatment of HIV-1 infection.

BMS-707035

HY-13269

BMS-707035 is an HIV-1 integrase (IN) inhibitor with an IC50 value of 15 nM.

CDK9-IN-1

HY-13231

CDK9-IN-1 is a novel, selective CDK9 inhibitor for the treatment of HIV infection.

D77

HY-18666

D77 is anti-HIV-1 inhibitor targeting the interaction between integrase and cellular LEDGF/p75.

Dapivirine

HY-14266

Dapivirine(TMC 120, TMC 120 R147681) is a NNRTI for HIV reverse transcriptase with IC50 of 24 nM, inhibits a broad panel of HIV-1 isolates from different classes, inclucing a wide range of NNRTI-resistant isolates.

Darunavir

HY-17040

Darunavir(TMC114) is an HIV protease inhibitor.

Darunavir Ethanolate

HY-17041

Darunavir ethanolate is an HIV protease inhibitor.