1. Anti-infection
  2. HIV

HIV

HIV (Human immunodeficiency virus) is a lentivirus (a subgroup of retrovirus) that causes the acquired immunodeficiency syndrome (AIDS), a condition in humans in which progressive failure of the immune system allows life-threatening opportunistic infections and cancers to thrive. Infection with HIV occurs by the transfer of blood, semen, vaginal fluid, pre-ejaculate, or breast milk. Within these bodily fluids, HIV is present as both free virus particles and virus within infected immune cells. HIV infects vital cells in the human immune system such as helper T cells (specifically CD4+ T cells), macrophages, and dendritic cells. HIV infection leads to low levels of CD4+ T cells through a number of mechanisms, including apoptosis of uninfected bystander cells, direct viral killing of infected cells, and killing of infected CD4+ T cells by CD8 cytotoxic lymphocytes that recognize infected cells. When CD4+ T cell numbers decline below a critical level, cell-mediated immunity is lost, and the body becomes progressively more susceptible to opportunistic infections.

HIV Related Products (113):

Cat. No. Product Name Effect Purity
  • HY-13004
    Maraviroc Inhibitor 99.71%
    Maraviroc is a selective CCR5 antagonist, inhibits MIP-1α (IC50, 3.3 nM), MIP-1β (IC50, 7.2 nM), and RANTES (IC50, 5.2 nM) binding to cell membrane preparations of CCR5-expressing HEK-293.
  • HY-13238
    Dolutegravir Inhibitor 99.54%
    Dolutegravir is a second-generation HIV integrase strand transfer inhibitor (INSTI) with an IC50 of 2.7 nM.
  • HY-90001
    Ritonavir Inhibitor 99.68%
    Ritonavir is an inhibitor of HIV protease used to treat HIV infection and AIDS.
  • HY-14882
    Cenicriviroc Inhibitor
    Cenicriviroc is an orally active, dual CCR2/CCR5 antagonist, also inhibits both HIV-1 and HIV-2, and displays potent anti-inflammatory and antiinfective activity.
  • HY-17367A
    Atazanavir sulfate Inhibitor 99.64%
    Atazanavir sulfate is a sulfate salt form of atazanavir that is an highly potent HIV-1 protease inhibitor.
  • HY-104012
    MK-8591 Inhibitor
    MK-8591 is a potent anti-HIV-1 agent, acting as a nucleoside reverse transcriptase inhibitor, with EC50s of 0.068 nM, 3.1 nM and 0.15 nM for HIV-1 (WT), HIV-1 (M184V), HIV-1 (MDR), respectively.
  • HY-P1586
    HIV-1 Rev 34-50 Inhibitor
    HIV-1 Rev (34-50) is a 17-aa peptide derived from the Rev-responsive element (RRE)-binding domains of Rev in HIV-1, with anti-HIV-1 activity.
  • HY-100096
    Emtricitabine S-oxide Inhibitor
    Emtricitabine Degradant-III is a major degradation product of Emtricitabine. Emtricitabine is a potent nucleoside reverse transcriptase inhibitor used for the treatment of HIV infection.
  • HY-14740
    Elvitegravir Inhibitor 99.92%
    Elvitegravir is an HIV integrase inhibitor for HIV-1IIIB, HIV-2EHO and HIV-2ROD with IC50 of 0.7 nM, 2.8 nM and 1.4 nM, respectively.
  • HY-B0250
    Lamivudine Inhibitor 99.64%
    Lamivudine is a potent nucleoside analog reverse transcriptase inhibitor with an IC50 of 2.7 mM.
  • HY-13750
    Ebselen Inhibitor 99.89%
    Ebselen is a small-molecule capsid Inhibitor of HIV-1 replication.
  • HY-15457
    Triciribine Inhibitor 99.20%
    Triciribine is a DNA synthesis inhibitor, also inhibits Akt and HIV-1/2 with IC50 of 130 nM, and 0.02-0.46 μM, respectively.
  • HY-15148
    Tipranavir Inhibitor 99.13%
    Tipranavir inhibits the enzymatic activity and dimerization of HIV-1 protease, exerts potent activity against multi-protease inhibitor (PI)-resistant HIV-1 isolates with IC50s of 66-410 nM.
  • HY-10353A
    Raltegravir potassium salt Inhibitor 99.96%
    Raltegravir (potassium salt) is a potent integrase (IN) inhibitor, used to treat HIV infection.
  • HY-10572
    Efavirenz Inhibitor 99.99%
    Efavirenz is a potent inhibitor of the wild-type HIV-1 reverse transcriptase with a Ki of 2.93 nM and exhibits an IC95 of 1.5 nM for the inhibition of HIV-1 replicative spread in cell culture.
  • HY-13782
    Tenofovir Disoproxil Fumarate Inhibitor 99.80%
    Tenofovir Disoproxil Fumarate is a nucleotide reverse transcriptase inhibitor used to treat HIV and chronic Hepatitis B.
  • HY-10571A
    Delavirdine mesylate Inhibitor 98.07%
    Delavirdine mesylate is a potent non-nucleoside HIV-1 reverse transcriptase inhibitor (NNRTI) of HIV-1.
  • HY-17007
    Saquinavir Inhibitor 99.91%
    Saquinavir(Ro 31-8959) is an HIV Protease inhibitor used in antiretroviral therapy.
  • HY-13685
    Miltefosine Inhibitor >98.0%
    Miltefosine is a broad spectrum antimicrobial, anti-leishmanial, phospholipid agent acting by inhibiting the PI3K/Akt activity.
  • HY-13406
    TAK-779 Inhibitor 99.73%
    TAK-779 is a potent and selective nonpeptide antagonist of CCR5 and CXCR3, with a Ki of 1.1 nM for CCR5, and effectively and selectively inhibits R5 HIV-1, with EC50 and EC90 of 1.2 nM and 5.7 nM, respectively, in MAGI-CCR5 cells.
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