1. Cell Cycle/DNA Damage
    Epigenetics
  2. HDAC
  3. HDAC2 Inhibitors

HDAC2 Inhibitors

HDAC

HDAC1

HDAC2

HDAC3

HDAC4

HDAC5

HDAC6

HDAC7

HDAC8

HDAC9

HDAC10

HDAC11

HD1

HD2

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Sorry. There is currently no product that acts on isoform HDAC2 together.

Please try each isoform separately.

HDAC2 Specific Inhibitors
Product Name HDAC2 HDAC HDAC1 HDAC3 HDAC4 HDAC5 HDAC6 HDAC7 HDAC8 HDAC9 HDAC10 HDAC11 HD1 HD2 HDAC2 Selectivity Purity
Santacruzamate A
HDAC2, IC50: 119 pM
         
HDAC6, IC50: 434 nM
              Selective Inhibitor 99.72%
Entinostat
HDAC2, IC50: 453 nM
 
HDAC1, IC50: 243 nM
HDAC3, IC50: 248 nM
                    Pan Inhibitor 99.65%
Romidepsin
HDAC2, IC50: 47 nM
 
HDAC1, IC50: 36 nM
 
HDAC4, IC50: 510 nM
 
HDAC6, IC50: 14000 nM
              Pan Inhibitor 99.98%
Ricolinostat
HDAC2, IC50: 48 nM
 
HDAC1, IC50: 58 nM
HDAC3, IC50: 51 nM
HDAC4, IC50: 7000 nM
HDAC5, IC50: 5000 nM
HDAC6, IC50: 4.7 nM
HDAC7, IC50: 1400 nM
HDAC8, IC50: 100 nM
          Pan Inhibitor 99.35%
Mocetinostat
HDAC2, IC50: 0.29 μM
 
HDAC1, IC50: 0.15 μM
HDAC3, IC50: 1.66 μM
             
HDAC11, IC50: 0.59 μM
    Pan Inhibitor 99.81%
Tubacin
HDAC2, IC50: 6.27 μM
 
HDAC1, IC50: 1.40 μM
HDAC3, IC50: 1.27 μM
HDAC4, IC50: 17.30 μM
HDAC5, IC50: 3.35 μM
HDAC6, IC50: 4 nM
HDAC7, IC50: 9.70 μM
HDAC8, IC50: 1.27 μM
HDAC9, IC50: 4.31 μM
HDAC10, IC50: 3.71 μM
HDAC11, IC50: 3.79 μM
    Pan Inhibitor 98.87%
Fimepinostat
HDAC2, IC50: 5 nM
 
HDAC1, IC50: 1.7 nM
HDAC3, IC50: 1.8 nM
HDAC4, IC50: 409 nM
HDAC5, IC50: 674 nM
HDAC6, IC50: 27 nM
HDAC7, IC50: 426 nM
HDAC8, IC50: 191 nM
HDAC9, IC50: 554 nM
HDAC10, IC50: 2.8 nM
HDAC11, IC50: 5.4 nM
    Pan Inhibitor 99.95%
Tacedinaline
HD2, IC50: 0.9 μM
 
HD1, IC50: 0.9 μM
HD3, IC50: 1.2 μM
                    Pan Inhibitor 99.08%
ACY-738
HDAC2, IC50: 128 nM
 
HDAC1, IC50: 94 nM
HDAC3, IC50: 218 nM
   
HDAC6, IC50: 1.7 nM
              Pan Inhibitor 99.94%
Abexinostat
HDAC2, Ki: 19 nM
 
HDAC1, Ki: 7 nM
HDAC3/SMRT, Ki: 8.2 nM
   
HDAC6, Ki: 17 nM
 
HDAC8, Ki: 280 nM
 
HDAC10, Ki: 24 nM
      Pan Inhibitor 98.61%
Nexturastat A
HDAC2, IC50: 6.92 μM
 
HDAC1, IC50: 3.02 μM
HDAC3, IC50: 6.68 μM
HDAC4, IC50: 9.39 μM
HDAC5, IC50: 11.7 μM
HDAC6, IC50: 5.02 nM
HDAC7, IC50: 4.46 μM
HDAC8, IC50: 0.954 μM
HDAC9, IC50: 6.72 μM
HDAC10, IC50: 7.57 μM
HDAC11, IC50: 5.14 μM
    Pan Inhibitor 97.92%
CAY10603
HDAC2, IC50: 252 nM
 
HDAC1, IC50: 271 nM
HDAC3, IC50: 0.42 nM
   
HDAC6, IC50: 0.002 nM
 
HDAC8, IC50: 6851 nM
 
HDAC10, IC50: 90.7 nM
      Pan Inhibitor 98.08%
ACY-775
HDAC2, IC50: 2570 nM
 
HDAC1, IC50: 2123 nM
HDAC3, IC50: 11223 nM
   
HDAC6, IC50: 7.5 nM
              Pan Inhibitor 99.54%
Pracinostat
HDAC2, IC50: 96 nM
 
HDAC1, IC50: 49 nM
HDAC3, IC50: 43 nM
HDAC4, IC50: 56 nM
HDAC5, IC50: 47 nM
HDAC6, IC50: 1008 nM
HDAC7, IC50: 137 nM
HDAC8, IC50: 140 nM
HDAC9, IC50: 70 nM
HDAC10, IC50: 40 nM
HDAC11, IC50: 93 nM
    Pan Inhibitor 99.07%
Citarinostat
HDAC2, IC50: 45 nM
 
HDAC1, IC50: 35 nM
HDAC3, IC50: 46 nM
   
HDAC6, IC50: 2.6 nM
HDAC7, IC50: 7300 nM
HDAC8, IC50: 137 nM
          Pan Inhibitor 99.06%
Givinostat hydrochloride monohydrate
hHDAC2, IC50: 325 nM
 
hHDAC1, IC50: 198 nM
hHDAC3, IC50: 157 nM
hHDAC4, IC50: 1059 nM
hHDAC5, IC50: 532 nM
hHDAC6, IC50: 315 nM
hHDAC7, IC50: 524 nM
hHDAC8, IC50: 854 nM
hHDAC9, IC50: 541 nM
hHDAC10, IC50: 340 nM
hHDAC11, IC50: 292 nM
HD1-B, IC50: 7.5 nM
HD1-A, IC50: 16 nM
HD2, IC50: 10 nM
Pan Inhibitor >98.0%
CUDC-101
HDAC2, IC50: 12.6 nM
HDAC, IC50: 4.4 nM
HDAC1, IC50: 4.5 nM
HDAC3, IC50: 9.1 nM
HDAC4, IC50: 13.2 nM
HDAC5, IC50: 11.4 nM
HDAC6, IC50: 5.1 nM
HDAC7, IC50: 373 nM
HDAC8, IC50: 79.8 nM
HDAC9, IC50: 67.2 nM
HDAC10, IC50: 26.1 nM
      Pan Inhibitor 99.59%
Domatinostat tosylate
HDAC-2, IC50: 1.12 μM
 
HDAC-1, IC50: 1.2 μM
HDAC-3, IC50: 0.57 μM
 
HDAC-5, IC50: 11.3 μM
     
HDAC-9, IC50: 50 μM
HDAC-10, IC50: 21 μM
HDAC-11, IC50: 9.7 μM
    Pan Inhibitor 98.81%
EDO-S101
HDAC2, IC50: 9 nM
 
HDAC1, IC50: 9 nM
HDAC3, IC50: 25 nM
   
HDAC6, IC50: 6 nM
 
HDAC8, IC50: 107 nM
 
HDAC10, IC50: 72 nM
      Pan Inhibitor 98.09%
HPOB
HDAC2, IC50: 4.4 μM
 
HDAC1, IC50: 2.9 μM
HDAC3/NCOR2, IC50: 1.7 μM
   
HDAC6, IC50: 0.056 μM
 
HDAC8, IC50: 2.8 μM
 
HDAC10, IC50: 3.0 μM
      Pan Inhibitor >95.0%
ACY-957
HDAC2, IC50: 18 nM
 
HDAC1, IC50: 7 nM
HDAC3, IC50: 1300 nM
                    Pan Inhibitor 98.96%
SR-4370
HDAC2, IC50: 580 nM
 
HDAC1, IC50: 130 nM
HDAC3, IC50: 6 nM
   
HDAC6, IC50: 3400 nM
 
HDAC8, IC50: 2300 nM
          Pan Inhibitor 98.33%
Pimelic Diphenylamide 106
HDAC2, IC50: 760 nM
 
HDAC1, IC50: 150 nM
HDAC3, IC50: 370 nM
       
HDAC8, IC50: 5000 nM
          Pan Inhibitor >98.0%
BG45
HDAC2, IC50: 2.2 μM
 
HDAC1, IC50: 2.0 μM
HDAC3, IC50: 0.289 μM
                    Pan Inhibitor 99.71 %
Domatinostat
HDAC-2, IC50: 1.12 μM
 
HDAC-1, IC50: 1.2 μM
HDAC-3, IC50: 0.57 μM
 
HDAC-5, IC50: 11.3 μM
     
HDAC-9, IC50: 50 μM
HDAC-10, IC50: 21 μM
HDAC-11, IC50: 9.7 μM
    Pan Inhibitor 98.99%
Givinostat
hHDAC2, IC50: 325 nM
 
hHDAC1, IC50: 198 nM
hHDAC3, IC50: 157 nM
hHDAC4, IC50: 1059 nM
hHDAC5, IC50: 532 nM
hHDAC6, IC50: 315 nM
hHDAC7, IC50: 524 nM
hHDAC8, IC50: 854 nM
hHDAC9, IC50: 541 nM
hHDAC10, IC50: 340 nM
hHDAC11, IC50: 292 nM
HD1-B, IC50: 7.5 nM
HD1-A, IC50: 16 nM
HD2, IC50: 10 nM
Pan Inhibitor
BRD73954
HDAC2, IC50: 9 μM
         
HDAC6, IC50: 0.036 μM
 
HDAC8, IC50: 0.12 μM
          Pan Inhibitor >98.0%
UF010
HDAC2, IC50: 0.1 μM
 
HDAC1, IC50: 0.5 μM
HDAC3, IC50: 0.06 μM
   
HDAC6, IC50: 9.1 μM
 
HDAC8, IC50: 1.5 μM
 
HDAC10, IC50: 15.3 μM
HDAC11, IC50: 44.5 μM
    Pan Inhibitor 99.36%
JAK/HDAC-IN-1
HDAC2, IC50: 14 nM
HDAC, IC50: 2 nM
       
HDAC6, IC50: 120 nM
 
HDAC8, IC50: 2470 nM
          Pan Inhibitor
Givinostat hydrochloride
hHDAC2, IC50: 325 nM
 
hHDAC1, IC50: 198 nM
hHDAC3, IC50: 157 nM
hHDAC4, IC50: 1059 nM
hHDAC5, IC50: 532 nM
hHDAC6, IC50: 315 nM
hHDAC7, IC50: 524 nM
hHDAC8, IC50: 854 nM
hHDAC9, IC50: 541 nM
hHDAC10, IC50: 340 nM
hHDAC11, IC50: 292 nM
HD1-B, IC50: 7.5 nM
HD1-A, IC50: 16 nM
HD2, IC50: 10 nM
Pan Inhibitor