Santacruzamate A (Synonyms: CAY-10683)

Name: Santacruzamate A
Brand: MedChemExpress
SKU: HY-N0931
Rating: 5.0 (19 reviews)

Cat. No.: HY-N0931 Purity: 99.54%: Data Sheet
COA

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Santacruzamate A (CAY-10683, STA) is a potent and selective HDAC2 inhibitor with an IC₅₀ of 119 pM. STA also exerts neuroprotective property against amyloid-β protein fragment 25–35. STA can be used for cancer and neurological disease research.

For research use only. We do not sell to patients.

CAS No. : 1477949-42-0

Size	Stock	Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO ready for reconstitution	In-stock	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	In-stock	Estimated Time of Arrival: December 31
Solid
5 mg	In-stock	Estimated Time of Arrival: December 31
10 mg	In-stock	Estimated Time of Arrival: December 31
25 mg	In-stock	Estimated Time of Arrival: December 31
50 mg	In-stock	Estimated Time of Arrival: December 31
100 mg	In-stock	Estimated Time of Arrival: December 31
200 mg	Get quote
500 mg	Get quote

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Customer Review

Based on 19 publication(s) in Google Scholar

Other Forms of Santacruzamate A:

Santacruzamate A (Standard) Get quote

19 Publications Citing Use of MCE Santacruzamate A

RT-PCR

Cell Proliferation/Viability Assay

Bio/Physico-chemical Assay

: Santacruzamate A purchased from MedChemExpress. Usage Cited in: Cancer Lett. 2025 Oct 10:630:217901. [Abstract]; Western blot assay of lysates from HepG2 and MHCC97H cells treated with Santacruzamate A (CAY-10683) (20 μM; 48 h).

: Santacruzamate A purchased from MedChemExpress. Usage Cited in: Cancer Lett. 2025 Oct 10:630:217901. [Abstract]; Santacruzamate A (CAY-10683) (20 μM; 24-72 h) impeded proliferation of HepG2 and MHCC97H cells.

: Santacruzamate A purchased from MedChemExpress. Usage Cited in: Cancer Lett. 2025 Oct 10:630:217901. [Abstract]; Santacruzamate A (CAY-10683) (20 μM; 48 h) impeded the total cholesterol concentration of HepG2 and MHCC97H cells.

: Santacruzamate A purchased from MedChemExpress. Usage Cited in: Br J Pharmacol. 2024 Oct;181(19):3663-3684. [Abstract]; Santacruzamate A (CAY-10683) (0.1 μM; 24 h) significantly up-regulated the mRNA expression of FXR, SHP, and FGF19 in IEC-6 cells.

: Santacruzamate A purchased from MedChemExpress. Usage Cited in: Br J Pharmacol. 2024 Oct;181(19):3663-3684. [Abstract]; Santacruzamate A (CAY-10683) (2 mg/kg; i.p.; 1 h; once daily for 4 weeks) decreased the contents of total triglyceride (TG) and total cholesterol (TC) in the sera and livers and the activities of AST and ALT in the sera of NAFLD (non-alcohol fatty liver disease) mice.

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HDAC HDAC1 HDAC2 HDAC3 HDAC4 HDAC5 HDAC6 HDAC7 HDAC8 HDAC9 HDAC10 HDAC11 HD1 HD2

Biological Activity
Purity & Documentation
References
Customer Review

Description

IC₅₀ & Target^[1]

HDAC2

119 pM (IC₅₀)

HDAC6

434 nM (IC₅₀)

Cellular Effect

Cell Line	Type	Value	Description	References
HCT-116	GI₅₀	17.2 μM Compound: 1; SCA; isolated	Antiproliferative activity against human HCT116 cells assessed as reduction in cell viability after 72 hrs by MTS-PMS assay Antiproliferative activity against human HCT116 cells assessed as reduction in cell viability after 72 hrs by MTS-PMS assay	[PMID: 27614919]
HCT-116	GI₅₀	28.3 μM Compound: 1, Synthetic SCA, santacruzamate A	Cytotoxicity against human HCT116 cells after 96 hrs by MTS-PMS assay Cytotoxicity against human HCT116 cells after 96 hrs by MTS-PMS assay	[PMID: 24164245]
HCT-116	GI₅₀	29.4 μM Compound: 1, natural product, SCA, santacruzamate A	Cytotoxicity against human HCT116 cells after 96 hrs by MTS-PMS assay Cytotoxicity against human HCT116 cells after 96 hrs by MTS-PMS assay	[PMID: 24164245]
HCT-116	GI₅₀	> 50 μM Compound: 1; SCA, synthetic	Antiproliferative activity against human HCT116 cells assessed as reduction in cell viability after 72 hrs by MTS-PMS assay Antiproliferative activity against human HCT116 cells assessed as reduction in cell viability after 72 hrs by MTS-PMS assay	[PMID: 27614919]
HCT-116	IC₅₀	> 50 μM Compound: 5a; SCA	Antiproliferative activity against human HCT116 cells after 24 hrs by MTT assay Antiproliferative activity against human HCT116 cells after 24 hrs by MTT assay	[PMID: 29100734]
HCT-116	IC₅₀	> 50 μM Compound: 5a; SCA	Antiproliferative activity against human HCT116 cells after 48 hrs by MTT assay Antiproliferative activity against human HCT116 cells after 48 hrs by MTT assay	[PMID: 29100734]
HCT-116	IC₅₀	> 50 μM Compound: 5a; SCA	Antiproliferative activity against human HCT116 cells after 72 hrs by MTT assay Antiproliferative activity against human HCT116 cells after 72 hrs by MTT assay	[PMID: 29100734]
HuT78	GI₅₀	1.3 μM Compound: 1, Synthetic SCA, santacruzamate A	Cytotoxicity against human HUT78 cells after 72 hrs by MTS-PMS assay Cytotoxicity against human HUT78 cells after 72 hrs by MTS-PMS assay	[PMID: 24164245]
HuT78	GI₅₀	1.4 μM Compound: 1, natural product, SCA, santacruzamate A	Cytotoxicity against human HUT78 cells after 72 hrs by MTS-PMS assay Cytotoxicity against human HUT78 cells after 72 hrs by MTS-PMS assay	[PMID: 24164245]
HuT78	GI₅₀	36 μM Compound: 1; SCA; isolated	Antiproliferative activity against human HUT78 cells assessed as reduction in cell viability after 70 hrs by Quanti-blue assay Antiproliferative activity against human HUT78 cells assessed as reduction in cell viability after 70 hrs by Quanti-blue assay	[PMID: 27614919]
HuT78	GI₅₀	> 50 μM Compound: 1; SCA, synthetic	Antiproliferative activity against human HUT78 cells assessed as reduction in cell viability after 70 hrs by Quanti-blue assay Antiproliferative activity against human HUT78 cells assessed as reduction in cell viability after 70 hrs by Quanti-blue assay	[PMID: 27614919]
MCF7	GI₅₀	> 50 μM Compound: 1; SCA, synthetic	Antiproliferative activity against human MCF7 cells assessed as reduction in cell viability after 72 hrs by MTS-PMS assay Antiproliferative activity against human MCF7 cells assessed as reduction in cell viability after 72 hrs by MTS-PMS assay	[PMID: 27614919]
MDA-MB-231	GI₅₀	> 50 μM Compound: 1; SCA, synthetic	Antiproliferative activity against human MDA-MB-231 cells assessed as reduction in cell viability after 72 hrs by MTS-PMS assay Antiproliferative activity against human MDA-MB-231 cells assessed as reduction in cell viability after 72 hrs by MTS-PMS assay	[PMID: 27614919]
MOLT-4	GI₅₀	7.8 μM Compound: 1; SCA; isolated	Antiproliferative activity against human MOLT4 cells assessed as reduction in cell viability after 70 hrs by Quanti-blue assay Antiproliferative activity against human MOLT4 cells assessed as reduction in cell viability after 70 hrs by Quanti-blue assay	[PMID: 27614919]
MOLT-4	GI₅₀	> 50 μM Compound: 1; SCA, synthetic	Antiproliferative activity against human MOLT4 cells assessed as reduction in cell viability after 70 hrs by Quanti-blue assay Antiproliferative activity against human MOLT4 cells assessed as reduction in cell viability after 70 hrs by Quanti-blue assay	[PMID: 27614919]
PBMC	GI₅₀	> 50 μM Compound: 1; SCA, synthetic	Antiproliferative activity against human PBMC assessed as reduction in cell viability after 70 hrs by Quanti-blue assay Antiproliferative activity against human PBMC assessed as reduction in cell viability after 70 hrs by Quanti-blue assay	[PMID: 27614919]

In Vitro

Santacruzamate A (0.016-50 μM, 28 h) attenuates amyloid-β protein fragment 25–35-induced apoptosis and reverses Aβ25–35-induced unfolded protein response and endoplasmic reticulum stress in PC12 and SH-SY5Y. 2 μM STA shows the strongest protective effects^[2].
Santacruzamate A (0.016-50 μM, 12 h) up-regulates KDEL receptor (KDELR) expression, reinforces ER luminal retention of chaperones, and enhances the binding of PERK to GRP78, inhibiting the amyloid-β protein fragment 25–35-induced mitochondrial fission and apoptosis pathways in PC12^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

278.35

Formula

C₁₅H₂₂N₂O₃

CAS No.

1477949-42-0

Appearance

Solid

Color

White to off-white

SMILES

O=C(OCC)NCCCC(NCCC1=CC=CC=C1)=O

Structure Classification

Initial Source

Microorganisms

Panamanian Marine Cyanobacterium

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	2 years
	-20°C	1 year

Solvent & Solubility

In Vitro:

DMSO : ≥ 100 mg/mL (359.26 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	3.5926 mL	17.9630 mL	35.9260 mL
5 mM	0.7185 mL	3.5926 mL	7.1852 mL
10 mM	0.3593 mL	1.7963 mL	3.5926 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.5 mg/mL (8.98 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Protocol 2

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 2.5 mg/mL (8.98 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
Protocol 3

Add each solvent one by one: 10% DMSO 90% Corn Oil
Solubility: ≥ 2.5 mg/mL (8.98 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

DMSO +

Tween-80 +

Saline

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Calculation results:

Working solution concentration: mg/mL

Method for preparing stock solution: mg drug dissolved in μL DMSO (Stock solution concentration: mg/mL).

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).

Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.

If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.

Purity & Documentation

Purity: 99.54%

Select Batch:

Data Sheet (270 KB) SDS (396 KB)

COA (242 KB) RP-HPLC (246 KB) MS (72 KB)

Handling Instructions (2659 KB)

References

[1]. Pavlik CM,et al. Santacruzamate A, a potent and selective histone deacetylase inhibitor from the Panamanian marine cyanobacterium cf. Symploca sp. J Nat Prod. 2013 Nov 22;76(11):2026-33. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	3.5926 mL	17.9630 mL	35.9260 mL	89.8150 mL
	5 mM	0.7185 mL	3.5926 mL	7.1852 mL	17.9630 mL
	10 mM	0.3593 mL	1.7963 mL	3.5926 mL	8.9815 mL
	15 mM	0.2395 mL	1.1975 mL	2.3951 mL	5.9877 mL
	20 mM	0.1796 mL	0.8981 mL	1.7963 mL	4.4907 mL
	25 mM	0.1437 mL	0.7185 mL	1.4370 mL	3.5926 mL
	30 mM	0.1198 mL	0.5988 mL	1.1975 mL	2.9938 mL
	40 mM	0.0898 mL	0.4491 mL	0.8981 mL	2.2454 mL
	50 mM	0.0719 mL	0.3593 mL	0.7185 mL	1.7963 mL
	60 mM	0.0599 mL	0.2994 mL	0.5988 mL	1.4969 mL
	80 mM	0.0449 mL	0.2245 mL	0.4491 mL	1.1227 mL
	100 mM	0.0359 mL	0.1796 mL	0.3593 mL	0.8981 mL

Santacruzamate A Related Classifications

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Santacruzamate A1477949-42-0CAY-10683CAY10683CAY 10683HDACAmyloid-βHistone deacetylasesβ-amyloid peptideAβAbetaHDAC2 inhibitorneuroprotectiveamyloid-β proteinAPPswe/PS1dE9 miceInhibitorinhibitorinhibit

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Santacruzamate A (Synonyms: CAY-10683)

Customer Review

Other Forms of Santacruzamate A:

Santacruzamate A Related Antibodies

19 Publications Citing Use of MCE Santacruzamate A

Featured Recommendations

•Related Screening Libraries:

•Related Small Molecules:

•Related Proteins:

View All HDAC Isoform Specific Products:

Biological Activity

Purity & Documentation

References

Customer Review

Santacruzamate A Related Antibodies

Molarity Calculator

Dilution Calculator

Complete Stock Solution Preparation Table

Santacruzamate A Related Classifications

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