Dendritic Cell CD Proteins
The cluster of differentiation (CD) antigens is a protocol used for the identification and investigation of cell surface molecules present on leukocytes. Some CD proteins often act as cell-cell or cell-matrix adhesion molecules, cytokine receptors, ion pores, or nutrient transporters. CD proteins play a variety of roles in immune system function. Dendritic cells (DC) are considered the most efficient antigen presenting cells (APC), uniquely able to induce naïve T cell activation and effector differentiation. In blood, DC constitute a rare cell population that can be broadly divided into two subtypes: CD123+CD11c- DC, called plasmacytoid DC (pDC), and CD123-CD11c+ cells, called classical DC or myeloid DC (cDC). Three antigens called BDCA-2, BDCA-3, and BDCA-4 (Blood Dendritic Cell Antigens) together with BDCA-1 (CD1c), which allow the further discrimination of human blood DC subsets. cDC can be separated into cDC1 and cDC2: cDC1 are characterized by the expression of BDCA-3 (CD141) and Clec9A, while cDC2 express CD1c. BDCA-2 (CD303) and-4 (CD304), on the other hand, together with CD123, characterize pDC.
- SIRP alpha/CD172a (34)
- 4-1BB (27)
- Integrin Associated Protein/CD47 (26)
- CTLA-4 (25)
- B7-H3/CD276 (21)
- Fc gamma RII/CD32 (21)
- Siglec-3/CD33 (20)
- Siglec-2/CD22 (20)
- CD326/EpCAM (20)
- CD40 (18)
- CD300a (17)
- CD3e (17)
- CD28 (17)
- CD4 (16)
- B7-1/CD80 (16)
- 4-1BBL (15)
- CD19 (15)
- B7-DC/PD-L2/CD273 (15)
- FCGR2A/CD32a (15)
- CD5 (15)
- CD8a (15)
- FcγRIIIA/CD16a (15)
- CD20 (14)
- CD36/SR-B2 (13)
- Fc-gamma Receptor I/CD64 (13)
- FcγRIIB/CD32b (12)
- NCAM-1/CD56 (12)
- B7-2/CD86 (12)
- CD85j/LIR-1 (11)
- CD319/SLAMF7 (11)
- B7-H2/CD275 (11)
- LAIR-1/CD305 (11)
- IL-3R alpha/CD123 (11)
- Flt-3/CD135 (11)
- CD85a/ILT-5 (10)
- CD2 (10)
- BDCA-4/CD304 (10)
- ICAM-1/CD54 (9)
- CD147 (9)
- CD353/SLAMF8 (8)
- CD14 (8)
- CD83 (8)
- CD200 (8)
- Siglec-5/CD170 (7)
- SIRP beta 1/CD172b (7)
- CD6 (7)
- CD44/ECMR-III (7)
- CD45 (7)
- CD99/MIC2 (6)
- DC-SIGN1/CD209 (5)
- CD1d (5)
- CD8b (5)
- FcγRIIIB/CD16b (5)
- CD43 (5)
- CD68 (5)
- LRP-1/CD91 (5)
- CD93 (5)
- ICAM-2/CD102 (5)
- CD150 (5)
- TLR3/CD283 (4)
- MCAM/CD146 (4)
- TREM-1/CD354 (4)
- CD74 (4)
- BDCA-3/CD141 (4)
- CD163 (4)
- CD171/L1CAM (4)
- MSR1/CD204 (4)
- BST-2/CD317 (4)
- 8D6A/CD320 (4)
- CD85e/LILRA3 (3)
- ILT-7/CD85g (3)
- DC-SIGN2/CLEC4M/CD299 (3)
- IREM-1/CD300f (3)
- LFA-3/CD58 (3)
- CCR2/CD192 (3)
- DEC-205/CD205 (3)
- Langerin/CD207 (3)
- CD11c (2)
- ICAM-3/CD50 (2)
- CD1a (2)
- CD5L (2)
- CD97 (2)
- TLR4/CD284 (1)
- CD49e/Integrin alpha-5 (1)
- CLM-7/CD300b (1)
- CD300c (1)
- CD300e (1)
- CD1c (1)