2. Recombinant Proteins
  3. CD Antigens
  4. Dendritic Cell CD Proteins

Dendritic Cell CD Proteins

Dendritic Cell CD Proteins

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The cluster of differentiation (CD) antigens is a protocol used for the identification and investigation of cell surface molecules present on leukocytes. Some CD proteins often act as cell-cell or cell-matrix adhesion molecules, cytokine receptors, ion pores, or nutrient transporters. CD proteins play a variety of roles in immune system function. Dendritic cells (DC) are considered the most efficient antigen presenting cells (APC), uniquely able to induce naïve T cell activation and effector differentiation. In blood, DC constitute a rare cell population that can be broadly divided into two subtypes: CD123+CD11c- DC, called plasmacytoid DC (pDC), and CD123-CD11c+ cells, called classical DC or myeloid DC (cDC). Three antigens called BDCA-2, BDCA-3, and BDCA-4 (Blood Dendritic Cell Antigens) together with BDCA-1 (CD1c), which allow the further discrimination of human blood DC subsets. cDC can be separated into cDC1 and cDC2: cDC1 are characterized by the expression of BDCA-3 (CD141) and Clec9A, while cDC2 express CD1c. BDCA-2 (CD303) and-4 (CD304), on the other hand, together with CD123, characterize pDC.

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