VISTA
V-domain immunoglobulin suppressor of T cell activation (VISTA, also known as DD1α, Gi24, Dies1, SISP1, C10orf54, PD-1H and B7-H5) is a negative immune checkpoint regulator that belongs to the B7-CD28 family. VISTA is highly expressed on hematopoietic cells, with the greatest densities in myeloid and granulocytic cells, and weaker expression on cluster of differentiation CD 4+ and CD8+ T cells. VISTA is a type I transmembrane protein with an extracellular IgV domain, a stalk region, a transmembrane segment, and a cytoplasmic tail. VISTA acts as inhibitory receptor on T cells, and also functions as a ligand when expressed on antigen-presenting cells (APCs). It regulates innate and adaptive anti-tumoral immune responses substantially.
-
VISTA Recombinant Proteins (12)
- Species:
- Source:
- 1
Recombinant Protein Expression Service
- Codon Optimization
- Gene Synthesis
- Construction of Expression Vector
- Strain Screening
- Protein Expression
- Purification & QC
- Protein Delivery
- 1
- Formula: Human
- Molecular Weight: Sf9 insect cells
The EpCAM/TROP1 protein serves as an important homogeneous interacting molecule that promotes direct contact between intestinal epithelial cells (IEC) and intraepithelial lymphocytes (IEL) in the mucosal epithelium. This feature helps establish an immune barrier against mucosal infections. EpCAM/TROP1 Protein, Human (His-SUMO) is the recombinant human-derived EpCAM/TROP1 protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag.
