1. Recombinant Proteins
  2. Receptor Proteins
  3. Nuclear Receptor Superfamily

Nuclear Receptor Superfamily

Nuclear receptors (NRs) are important transcription factors capable of exerting regulation of gene expression in the nucleus in response to various extracellular and intracellular signals. NRs are activated by binding of small hydrophobic compounds, such as steroids, retinoids, and thyroid hormones. The interaction of ligand and receptor triggers a conformational change in the receptor proteins, which enables an interaction with cofactors and specific cis-regulatory DNA sequences called hormone response elements (HREs) to subsequently modify gene expression. NRs are involved in widely diverse physiological functions such as control of development, reproduction, metabolism, cell differentiation, and homeostasis. NRs share a similar modular domain structure, which includes, from N-terminus to C-terminus: 1) domains A and B make up the highly variable (both in length and sequence) amino/N-terminal domain (NTD); 2) the DNA-binding domain (DBD), which consists of two zinc finger DNA-binding motifs; 3) the hinge D-region, often contains the main nuclear localization sequence (NLS); 4) the ligand-binding domain (LBD); 5) some receptors also contain a short, variable carboxy/C-terminal domain (CTD; F domain). Most NRs are regulated endogenously by small lipophilic ligands, but this protein family also contains “orphan” members for which lack identified ligand molecules. NRs are divided into seven subfamilies, Subgroup 0 to Subgroup 6, based on sequence alignment and phylogenetic tree construction. Among them, the Subgroup 1 is large family which is formed by thyroid hormone receptors (TR), retinoic acid receptors (RAR), peroxisome proliferator activated receptors (PPAR), reverse-Erb receptors (REV-ERB, retinoic acid related receptors (ROR), farnesoid X receptors (FXR), liver X receptors (LXR), and vitamin D receptors (VDR).

Cat. No. Product Name / Synonyms Species Source
  • HY-P7996
    PPAR alpha Protein, human (His)


    Human E. coli
    PPAR alpha Protein, human (His), a member of the nuclear receptor family, is a transcription factor that regulates the expression of genes related to lipid metabolism in a ligand-dependent manner.
  • HY-P7999
    PPAR gamma Protein, Human (His)


    Human E. coli
    PPAR gamma LBD Protein, Human (His) is a His-fused PPAR-gamma-LBD protein expressed by E. coli, approximately 32.6 kDa. PPAR gamma LBD Protein can be used in the ligand screening assays, western blotting, and ELISA, et al.
  • HY-P70248
    ER alpha/ESR1 Protein, Human (His)

    rHuEstrogen receptor/ER alpha, His; Estrogen Receptor; ER; ER-Alpha; Estradiol Receptor; Nuclear Receptor Subfamily 3 Group A Member 1; ESR1; ESR; NR3A1

    Human E. coli
  • HY-P72088
    Androgen receptor Protein, Human (His-SUMO)

    AIS; ANDR_HUMAN; Androgen nuclear receptor variant 2; Androgen receptor dihydrotestosterone receptor; testicular feminization; SBMA; SMAX1; Testicular Feminization TFM; TFM

    Human E. coli
  • HY-P70791
    ER beta/ESR2 Protein, Human (His)

    Estrogen Receptor Beta; ER-Beta; Nuclear Receptor Subfamily 3 Group A Member 2; ESR2; ESTRB; NR3A2

    Human E. coli
  • HY-P700275
    PPAR gamma Protein, Human (C-His)


    Human E. coli
  • HY-P73701
    PPAR gamma Protein, Human (sf9, His-GST)


    Human Sf9 insect cells
Cat. No. Product Name Effect Purity