1. Customized Service
  2. ADC-Related Custom Services

ADC-Related Custom Services

MCE owns a strong technical team and state-of-the-art facilities. For ADC products, we have rich experience in research development and production. We continue to make breakthroughs and innovations, synthesize different types of ADC products according to customer requirements, and ensure effectiveness and consistency of products and high-quality and efficient service. MCE can provide one-stop services for the design, synthesis, analysis, purification, optimization, detection and evaluation of ADC-related products (ADC Cytotoxin, ADC Linker, Drug-Linker Conjugates for ADC and Antibody-drug Conjugate (ADC)).

Service Scope

ADC Cytotoxin Custom Synthesis-we can help synthesize ADC Cytotoxins.
Cytotoxin Modification-we can perform the modifications of existing cytotoxins.
ADC Linker Custom Synthesis-we can help synthesize ADC Linkers.
Linker Modification-we can perform the modifications of existing linkers.
Drug-Linker Conjugates
for ADC
Custom Synthesis-we can help design and synthesize Drug-Linker Conjugates for ADC.
Structural Modification-we can perform the modifications of existing Drug-Linker Conjugates.
Conjugation Strategy Conventional Conjugation-we can provide amine-based lysine conjugation and thiol-based cysteine conjugation.
Site-Specific Conjugation-we can also provide engineered cysteine residues, unnatural amino acids or enzymatic conjugation.
Antibody-Drug Conjugate Custom Synthesis-we can help design and synthesize Antibody-Drug Conjugates (ADCs).
ADC Characterization-we can also perform the detection of Drug-to-Antibody ratio (DAR), free drug, endotoxin and so on.
Peptide-Drug Conjugate Custom Synthesis-we can help design and synthesize Peptide-Drug Conjugates (PDCs).
PDC Characterization-we can also provide purity, stability and other relevant information about PDCs.
Aptamer-Drug Conjugate Custom Synthesis-we can help design and synthesize Aptamer-Drug Conjugates (ApDCs).
ApDC Characterization-we can also provide purity, stability and other relevant information about ApDCs.

ADC-Related Products Links

Read more about
ADC Cytotoxin
Read more about
ADC Linker
Read more about
Drug-Linker Conjugates for ADC
Read more about
Antibody-Drug Conjugate (ADC)

The Key Factors to Design Antibody-Drug Conjugates

The selection of Payloads

The payloads are the ultimate effector components of therapeutic antibody-drug conjugates (ADCs). Ideally, the potency of the cytotoxic payload should be extremely high. Also, they should have reasonable solubility, sufficient stability, low immunogenicity, and a long half-life.

The selection of Linkers

An ideal linker between the cytotoxic payload and the antibody should be stable in circulation. At the same time, it must rapidly and efficiently release the cytotoxic agent inside the tumor cells. In addition, it needs to possess high hydrophilicity.

The selection of Drug-Linker Conjugates for ADC

Drug-linker conjugates, which consist of a cytotoxic payload and an appropriate linker, can be directly linked to monoclonal antibodies, composing the immunoconjugates for cancer therapy.

The selection of Antibodies

Ideal antibodies need to have high specificity and affinity for tumor associated antigens, good stability, low immunogenicity, low cross reaction, long circulating half-life and effective internalization.

The selection of Conjugation strategies

Currently, the conventional conjugation strategies include amine-based lysine and thiol-based cysteine conjugation. In addition, site-specific conjugation (SSC) strategies include engineered cysteine residues, unnatural amino acids and enzymatic conjugation through glycotransferases and transglutaminases.

Our Advantages

We have more than 900 ADC-related products. We have the strong ability and rich experience in the synthesis of highly complex compounds, and perform the design and synthesis of payloads and linkers. We developed new synthetic process routes by continuous technological innovation, and established cooperative relations with well-known pharmaceutical enterprises such as Abbvie and AstraZeneca.

Covenient delivery The finished products can be delivered for use at the first time, reducing the intermediate links. Price concessions ADC products have high cost performance and favorable prices. Product reports MCE provide you with real and reliable experimental data related to ADCs. Instrict confidence After confirming ADC products, MCE and you will sign a confidentiality aggrement, and your information enjoys absolute security. Free consultation For-presales and after-sales consultation of ADC products, professional ADC technicians will answer your questions and solve your doubts for free.

Service and Consulting

The corresponding scheme and price for ADC-related custom services shall be determined after evaluation. For further information on service pricing or technical details, please email [email protected] or contact MCE sales staff directly.