1. Signaling Pathways
  2. Antibody-drug Conjugate/ADC Related
  3. ADC Linker

ADC Linker

Antibody-drug conjugates linker

Antibody-drug conjugates (ADCs) consist of a desirable monoclonal antibody, an active cytotoxic drug and an appropriate linker. An appropriate linker between the antibody and the cytotoxic drug provides a specific bridge, and thus helps the antibody to selectively deliver the cytotoxic drug to tumor cells and accurately releases the cytotoxic drug at tumor sites. In addition to conjugation, the linkers maintain ADCs’ stability during the preparation and storage stages of the ADCs and during the systemic circulation period.

The ADCs currently undergoing clinical evaluation contain linkers are mostly classified into two categories: cleavable and noncleavable. Cleavable linkers rely on processes inside the cell to liberate the toxin, such as reduction in the cytoplasm, exposure to acidic conditions in the lysosome, or cleavage by specific proteases within the cell. Noncleavable linkers require proteolytic degradation of the antibody portion of the ADC for release of the cytotoxic molecule, which will retain the linker and the amino acid by which it was attached to the antibody.

The selection of linker is target dependent, based on the knowledge of the internalization and degradation of the antibody-target antigen complex, and a preclinical in vitro and in vivo activity comparison of conjugates. Moreover, the choice of a linker is also influenced by which cytotoxin is used, as each molecule has different chemical constraints, and frequently the drug structure lends itself to a specific linker.

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-W019543
    DSS Crosslinker
    ≥98.0%
    DSS Crosslinker is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
    DSS Crosslinker
  • HY-20336
    Mc-Val-Cit-PABC-PNP
    98.89%
    Mc-Val-Cit-PABC-PNP is a cathepsin cleavable linker for antibody-drug conjugates (ADCs) which couples the antibody element to the effecting compound. Mc-Val-Cit-PABC-PNP can be used in the synthesis of ADCs.
    Mc-Val-Cit-PABC-PNP
  • HY-42973
    DBCO-NHS ester
    99.53%
    DBCO-NHS ester is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). DBCO-NHS ester is a click chemistry reagent, it contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups.
    DBCO-NHS ester
  • HY-42360
    SMCC
    99.25%
    SMCC is a protein crosslinker. SMCC-conjugated antigen coupled spleen cells to induce antigen-specific immune responses.
    SMCC
  • HY-78738
    MC-Val-Cit-PAB
    99.38%
    MC-Val-Cit-PAB is an intermediate in the synthesis of VcMMAE (HY-15575), which is a Drug-Linker Conjugates for ADC. Monomethyl auristatin E can be used to inhibit Microtubule/Tubulin as ADC Cytotoxin.
    MC-Val-Cit-PAB
  • HY-44980
    Fmoc-Gly-NH-CH2-acetyloxy
    Fmoc-Gly-NH-CH2-acetyloxy is a cleavable linker that can be used to synthesize antiboy-drug Conjugates (ADCs).
    Fmoc-Gly-NH-CH2-acetyloxy
  • HY-78932A
    Dap-NE hydrochloride
    99.98%
    Dap-NE hydrochloride is a dipeptide hydrochloride and a cleavable ADC Linker.Dap-NE hydrochloride can be used to connect Antibody and toxin molecules (Cytotoxin) to synthesize Antibody-Drug Conjugates (ADCs).
    Dap-NE hydrochloride
  • HY-161022A
    FL118-C3-O-C-amide-C-NH2 formate
    FL118-C3-O-C-amide-C-NH2 (compound 6a) formate is an ADC linker that can be used to synthesize synthetic antibody-conjugated active molecules (ADCs).
    FL118-C3-O-C-amide-C-NH2 formate
  • HY-D0975
    Sulfo-SMCC sodium
    98.30%
    Sulfo-SMCC sodium is a commonly used hetero-bifunctional, noncleavable ADC crosslinker bearing N-hydroxysuccinimide (NHS) ester and maleimide groups to react with primary amines and sulfhydryl groups, respectively.
    Sulfo-SMCC sodium
  • HY-114697
    DSG Crosslinker
    98.13%
    DSG Crosslinker is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
    DSG Crosslinker
  • HY-118759
    DSP Crosslinker
    98.73%
    DSP Crosslinker is a cleavable ADC linker, used in the synthesis of antibody-drug conjugates (ADCs).
    DSP Crosslinker
  • HY-78921
    Fmoc-3VVD-OH
    99.99%
    Fmoc-3VVD-OH is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
    Fmoc-3VVD-OH
  • HY-133540
    Maleimide-DOTA
    99.17%
    Maleimide-DOTA is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
    Maleimide-DOTA
  • HY-W000423
    DBCO-amine
    99.77%
    DBCO-amine is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). DBCO-amine is a click chemistry reagent, it contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups.
    DBCO-amine
  • HY-12362
    Val-cit-PAB-OH
    99.62%
    Val-cit-PAB-OH is a cleavable ADC linker.
    Val-cit-PAB-OH
  • HY-131990
    MC-Gly-Gly-Phe-Gly-NH-CH2-O-CH2COOH
    98.73%
    MC-Gly-Gly-Phe-Gly-NH-CH2-O-CH2COOH is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
    MC-Gly-Gly-Phe-Gly-NH-CH2-O-CH2COOH
  • HY-100216
    SPDP
    ≥98.0%
    SPDP (SPDP Crosslinker) is a short-chain crosslinker for amine-to-sulfhydryl conjugation via NHS-ester and pyridyldithiol reactive groups that form cleavable (reducible) disulfide bonds with cysteine sulfhydryls. It is a glutathione cleavable ADC linker used for the antibody-drug conjugates (ADCs).
    SPDP
  • HY-44222
    MAC glucuronide linker-2
    99.38%
    MAC glucuronide linker-2 is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
    MAC glucuronide linker-2
  • HY-150230
    Desthiobiotin-Iodoacetamide
    Desthiobiotin-Iodoacetamide can be used as an ADC Linker. Desthiobiotin-Iodoacetamide also acts as a probe used to label the the Oridonin (HY-N0004)-treated cell lysis.
    Desthiobiotin-Iodoacetamide
  • HY-130109
    N3-PEG4-C2-NHS ester
    98.94%
    N3-PEG4-C2-NHS ester is a nonclaevable 4-unit PEG linker used in the synthesis of antibody-drug conjugates (ADCs). N3-PEG4-C2-NHS ester is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. Strain-promoted alkyne-azide cycloaddition (SPAAC) can also occur with molecules containing DBCO or BCN groups.
    N3-PEG4-C2-NHS ester

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