1. Signaling Pathways
  2. Antibody-drug Conjugate/ADC Related
  3. ADC Linker

ADC Linker

Antibody-drug conjugates (ADCs) consist of a desirable monoclonal antibody, an active cytotoxic drug and an appropriate linker. An appropriate linker between the antibody and the cytotoxic drug provides a specific bridge, and thus helps the antibody to selectively deliver the cytotoxic drug to tumor cells and accurately releases the cytotoxic drug at tumor sites. In addition to conjugation, the linkers maintain ADCs’ stability during the preparation and storage stages of the ADCs and during the systemic circulation period.

The ADCs currently undergoing clinical evaluation contain linkers are mostly classified into two categories: cleavable and noncleavable. Cleavable linkers rely on processes inside the cell to liberate the toxin, such as reduction in the cytoplasm, exposure to acidic conditions in the lysosome, or cleavage by specific proteases within the cell. Noncleavable linkers require proteolytic degradation of the antibody portion of the ADC for release of the cytotoxic molecule, which will retain the linker and the amino acid by which it was attached to the antibody.

The selection of linker is target dependent, based on the knowledge of the internalization and degradation of the antibody-target antigen complex, and a preclinical in vitro and in vivo activity comparison of conjugates. Moreover, the choice of a linker is also influenced by which cytotoxin is used, as each molecule has different chemical constraints, and frequently the drug structure lends itself to a specific linker.

ADC Linker Related Products (39):

Cat. No. Product Name Effect Purity
  • HY-78738
    MC-Val-Cit-PAB 99.66%
    MC-Val-Cit-PAB is a cathepsin cleavable ADC linker that is used for making antibody-drug conjugate. FDA approved drugs such as brentuximab vedotin use this linker.
  • HY-12362
    Val-cit-PAB-OH 99.64%
    Val-cit-PAB-OH is a peptide prodrug linker.
  • HY-41189
    Fmoc-Val-Cit-PAB-PNP is a peptide prodrug linker, is a linker for antibody-drug-conjugation (ADC).
  • HY-20336
    Mc-Val-Cit-PABC-PNP 98.68%
    Mc-Val-Cit-PABC-PNP is a cathepsin cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
  • HY-43869
    Vipivotide tetraxetan Linker
    Vipivotide tetraxetan Linker is a useful peptide linker for synthesis of Vipivotide tetraxetan (PSMA-617). Vipivotide tetraxetan (PSMA-617) is a ligand used to synthesize 177Lu-PSMA-617, which is a radioactive molecule for the treatment of prostate cancer.
  • HY-101159
    Mal-amido-PEG8-acid (example 143) is an ADC linker, extracted from patent US2018339985.
  • HY-128946
    CL2A-SN-38, SN-38 (topoisomerase-I inhibitor) derivative, is a peptide linker. CL2A-SN-38 is conjugated to the anti-Trop-2-humanized antibody, SN-38-anti-Trop-2 antibody-drug conjugate (ADC) against several human solid tumor types, provides significant and specific antitumor effects against a range of human solid tumor types.
  • HY-114430
    Fmoc-Phe-Lys(Boc)-PAB-PNP 98.67%
    Fmoc-Phe-Lys(Boc)-PAB-PNP is an ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
  • HY-78961
    6-Maleimidohexanoic acid N-hydroxysuccinimide ester 99.96%
    6-Maleimidohexanoic acid N-hydroxysuccinimide ester(ECMS) is a useful protective group in antibody drug conjugates.
  • HY-19318
    Fmoc-Val-Cit-PAB 98.13%
    Fmoc-Val-Cit-PAB is a linker for antibody-drug-conjugation (ADC).
  • HY-21210
    6-Quinoxalinecarboxylic acid, 2,3-bis(bromomethyl)-
    6-Quinoxalinecarboxylic acid, 2,3-bis(bromomethyl)- is an useful linker for antibody-drug-conjugations (ADCs), extracted from [Bioorg Chem. 2012 Apr-Jun;41-42:1-5.] compound 1i.
  • HY-128944
    MAC glucuronide linker
    MAC glucuronide linker is a linker for antibody-drug-conjugations (ADCs) and is useful to prepare the MAC glucuronide SN-38 drug linker.
  • HY-111434
    UAA crosslinker 1
    UAA crosslinker 1 hydrochloride is an amber codon used for non-canonical amino acids (ncAAs) incorporation. The ncAAs can be incorporated into proteins in vivo by making use of the promiscuous activity of certain wildtype and engineered aminoacyl-tRNA synthetases.
  • HY-128960
    SPDB-DM4 linker
    SPDB linker is a glutathione cleavable linker used for the antibody-drug conjugate (ADC).
  • HY-128950
    MC-VC-PABC-MMAE is a noncleavable ADC linker used in the synthesis of antibody-drug conjugates.
  • HY-128925
    AMAS is a heterobifunctional crosslinker with NHS ester and maleimide groups that allows covalent conjugation of amine- and sulfhydryl-containing molecules.
  • HY-W000438
    N-Boc-O-tosyl hydroxylamine
    N-Boc-O-tosyl hydroxylamine is used as a linker for antibody-drug conjugates (ADC).
  • HY-128970
    Mp-polymer ester
    Mp-polymer ester is a noncleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
  • HY-128930
    6-O-2-Propyn-1-yl-D-galactose is a glycolinker for the functionalization of cytotoxic drugs and applications in antibody-drug conjugation.
  • HY-128959
    MC-VA-Modified PABC
    MC-VA-Modified PABC is a noncleavable ADC linker used in the synthesis of antibody-drug conjugates.
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