1. Antibody-drug Conjugate/ADC Related
  2. ADC Linker
  3. SMCC

SMCC 

Cat. No.: HY-42360 Purity: >98.0%
Handling Instructions

SMCC is a protein crosslinker. SMCC-conjugated antigen coupled spleen cells to induce antigen-specific immune responses.

For research use only. We do not sell to patients.

SMCC Chemical Structure

SMCC Chemical Structure

CAS No. : 64987-85-5

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Estimated Time of Arrival: December 31
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Based on 1 publication(s) in Google Scholar

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Description

SMCC is a protein crosslinker. SMCC-conjugated antigen coupled spleen cells to induce antigen-specific immune responses[1].

In Vitro

SMCC or sulfo-SMCC can use to conjugate keyhole limpet hemocyanin (KLH) and ovalbumin (OVA). In the the conjugation system, 300 μl KLH or OVA (3 mg) and 30 μl SMCC or Sulfo-SMCC (the final concentration of 0.1 mM) are added in PBS with final volume of 3 ml[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Using the SMCC-conjugation method is able to induce potent immune responses to whole protein or peptide antigens by injection of antigen-coupled syngeneic splenic mononuclear cells in mice[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

334.32

Formula

C₁₆H₁₈N₂O₆

CAS No.

64987-85-5

SMILES

O=C(C1CCC(CN2C(C=CC2=O)=O)CC1)ON3C(CCC3=O)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 25 mg/mL (74.78 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.9911 mL 14.9557 mL 29.9115 mL
5 mM 0.5982 mL 2.9911 mL 5.9823 mL
10 mM 0.2991 mL 1.4956 mL 2.9911 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (7.48 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (7.48 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (7.48 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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This equation is commonly abbreviated as: C1V1 = C2V2

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Keywords:

SMCCADC LinkerAntibody-drug conjugates linkerInhibitorinhibitorinhibit

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SMCC
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HY-42360
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