1. Apoptosis
  2. PKD

PKD

PKD (Protein kinase D) is an evolutionarily conserved protein kinase family with structural, enzymological, and regulatory properties different from the PKC family members. Signaling through PKD is induced by a remarkable number of stimuli, including G-protein-coupled receptor agonists and polypeptide growth factors. PKD family of serine/threonine protein kinases has three members: PKD1, PKD2, PKD3. PKD1, the most studied member of the family, is increasingly implicated in the regulation of a complex array of fundamental biological processes, including signal transduction, cell proliferation and differentiation, membrane trafficking, secretion, immune regulation, cardiac hypertrophy and contraction, angiogenesis, and cancer. PKD mediates such a diverse array of normal and abnormal biological functions via dynamic changes in its spatial and temporal localization, combined with its distinct substrate specificity.

PKD Isoform Specific Products:

  • PKD1

  • PKD2

  • PKD3

PKD Related Products (6):

Cat. No. Product Name Effect Purity
  • HY-13942
    1-NM-PP1 Inhibitor 98.83%
    1-NM-PP1 is a cell permeable protein kinase D (PKD) inhibitor with an IC50 of 0.398 μM.
  • HY-12239
    CID755673 Inhibitor 98.98%
    CID755673 is a potent and selective PKD1 inhibitor with an IC50 of 182 nM.
  • HY-15698A
    CRT0066101 dihydrochloride Inhibitor 98.94%
    CRT0066101 dihydrochloride is a potent and specific PKD inhibitor with IC50 values of 1, 2.5 and 2 nM for PKD1, 2, and 3 respectively.
  • HY-13454
    CID 2011756 Inhibitor
    CID 2011756 is an ATP competitive PKD inhibitor, with an IC50 of 3.2 µM for PKD1 in cell free assay, and also shows cellular pan-PKD inhibitory activity against PKD2 and PKD3 (IC50, 0.6 and 0.7 µM, respectively). CID 2011756 also has antitumor activity.
  • HY-15528
    kb NB 142-70 Inhibitor 98.24%
    kb NB 142-70 is a potent PKD inhibitor, with IC50s of 28.3, 58.7 and 53.2 nM for PKD1, PKD2, and PKD3, respectively. kb NB 142-70 also has antitumor activity.
  • HY-16698
    kb-NB77-78 Inhibitor
    kb-NB77-78 is an analogue of CID797718, but shows no PKD inhibitory activity[1].
Isoform Specific Products

Your Search Returned No Results.

Sorry. There is currently no product that acts on isoform together.

Please try each isoform separately.